Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 3 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of FURIN and ZPR1 polymorphisms with metabolic syndrome

  • Authors:
    • Chikara Ueyama
    • Hideki Horibe
    • Yuichiro Yamase
    • Tetsuo Fujimaki
    • Mitsutoshi Oguri
    • Kimihiko Kato
    • Masazumi Arai
    • Sachiro Watanabe
    • Toyoaki Murohara
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511‑0428, Japan, Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi 453‑8511, Japan, Department of Internal Medicine, Meitoh Hospital, Nagoya, Aichi 465‑0025, Japan, Department of Cardiology, Gifu Prefectural General Medical Center, Gifu 500‑8717, Japan, Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan
  • Pages: 641-647
    |
    Published online on: June 29, 2015
       https://doi.org/10.3892/br.2015.484
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although genome-wide association studies (GWASs) have identified various genes and loci in predisposition to metabolic syndrome (MetS) or each component of this condition, the genetic basis of MetS in individuals remains to be identified definitively. The aim of the present study was to examine the possible association of MetS in individuals with 29 polymorphisms that were previously identified as susceptibility loci for coronary artery disease or myocardial infarction by meta‑analyses of GWASs. The study population comprised 1,822 subjects with MetS and 1,096 controls. Subjects with MetS had ≥3 of the 5 components of the diagnostic criteria for MetS, whereas control individuals had 0‑1 of the 5 components. The genotypes for the 29 polymorphisms were determined by the multiplex bead‑based Luminex assay. Comparisons of allele frequencies by the χ2 test revealed that rs17514846 (A→C) of the furin (paired basic amino acid‑cleaving enzyme) gene (FURIN; P=0.0006), rs964184 (C→G) of the ZPR1 zinc finger gene (ZPR1; P=0.0078) and rs599839 (G→A) of the proline/serine‑rich coiled‑coil 1 gene (P=0.0486) were significantly (P<0.05) associated with the prevalence of MetS. Multivariable logistic regression analysis with adjustment for age, gender and smoking status revealed that rs17514846 of FURIN (P=0.0016; odds ratio, 0.76; dominant model) and rs964184 of ZPR1 (P=0.0164; odds ratio, 1.21; dominant model) were significantly associated with MetS. The minor A allele of rs17514846 of FURIN was significantly associated with a decrease in the serum concentration of triglycerides (P=0.0293) and to an increase in the serum concentration of high‑density lipoprotein (HDL) cholesterol (P=0.0460). The minor G allele of rs964184 of ZPR1 was significantly associated with increases in the serum concentration of triglycerides (P=6.2x10‑9) and fasting plasma glucose level (P=0.0028) and to a decrease in the serum concentration of HDL cholesterol (P=0.0105). FURIN and ZPR1 may thus be susceptibility loci for MetS.
View Figures
View References

1 

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM and Smith SC JrInternational Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity: Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 120:1640–1645. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Alberti KG, Zimmet P and Shaw JIDF Epidemiology Task Force Consensus Group: The metabolic syndrome - a new worldwide definition. Lancet. 366:1059–1062. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Olijhoek JK, van der Graaf Y, Banga J-D, Algra A, Rabelink TJ and Visseren FLSMART Study Group: The metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm. Eur Heart J. 25:342–348. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Groop L: Genetics of the metabolic syndrome. Br J Nutr. 83 (Suppl 1):S39–S48. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Park YM, Province MA, Gao X, Feitosa M, Wu J, Ma D, Rao D and Kraja AT: Longitudinal trends in the association of metabolic syndrome with 550 k single-nucleotide polymorphisms in the Framingham Heart Study. BMC Proc. 3 (Suppl 7):S1162009. View Article : Google Scholar : PubMed/NCBI

6 

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, et al Wellcome Trust Case Control Consortium: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 40:638–645. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, et al: Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet. 40:149–151. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 316:889–894. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, et al Cardiogenics; CARDIoGRAM Consortium: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, et al CARDIoGRAMplusC4D Consortium; DIAGRAM Consortium; CARDIOGENICS Consortium; MuTHER Consortium; Wellcome Trust Case Control Consortium: Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25–33. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Sattar N, Gaw A, Scherbakova O, Ford I, O'Reilly DS, Haffner SM, Isles C, Macfarlane PW, Packard CJ, Cobbe SM, et al: Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation. 108:414–419. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Ridker PM, Buring JE, Cook NR and Rifai N: C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8-year follow-up of 14,719 initially healthy American women. Circulation. 107:391–397. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P and Inoue S: Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pac J Clin Nutr. 11 (Suppl 8):S732–S737. 2002. View Article : Google Scholar

14 

Matsuoka R, Abe S, Tokoro F, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, et al: Association of six genetic variants with myocardial infarction. Int J Mol Med. 35:1451–1459. 2015.PubMed/NCBI

15 

Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, Yoshida H, Satoh K, Kato K, Watanabe S, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 207:144–149. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, et al: Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis. 215:145–152. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Yamada Y, Nishida T, Ichihara S, Kato K, Fujimaki T, Oguri M, Horibe H, Yoshida T, Watanabe S, Satoh K, et al: Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. J Med Genet. 50:410–418. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Itoh Y, Mizuki N, Shimada T, Azuma F, Itakura M, Kashiwase K, Kikkawa E, Kulski JK, Satake M and Inoko H: High-throughput DNA typing of HLA-A, -B, -C and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, et al: Substrate cleavage analysis of furin and related proprotein convertases. A comparative study. J Biol Chem. 283:20897–20906. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Blanchette F, Day R, Dong W, Laprise MH and Dubois CM: TGFbeta1 regulates gene expression of its own converting enzyme furin. J Clin Invest. 99:1974–1983. 1997. View Article : Google Scholar : PubMed/NCBI

21 

Pesu M, Muul L, Kanno Y and O'Shea JJ: Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma. Blood. 108:983–985. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikäinen LP, Järvinen O, Creemers JW, Kähönen M, Laaksonen R, et al: Proprotein convertases in human atherosclerotic plaques: The overexpression of FURIN and its substrate cytokines BAFF and APRIL. Atherosclerosis. 219:799–806. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Turpeinen H, Ortutay Z and Pesu M: Genetics of the first seven proprotein convertase enzymes in health and disease. Curr Genomics. 14:453–467. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Bassi DE, Mahloogi H, Al-Saleem L, Lopez De Cicco R, Ridge JA and Klein-Szanto AJ: Elevated furin expression in aggressive human head and neck tumors and tumor cell lines. Mol Carcinog. 31:224–232. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Ornatowski W, Poschet JF, Perkett E, Taylor-Cousar JL and Deretic V: Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity. J Clin Invest. 117:3489–3497. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Cousin C, Bracquart D, Contrepas A, Corvol P, Muller L and Nguyen G: Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. Hypertension. 53:1077–1082. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, et al CHARGE-HF consortium: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478:103–109. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Li N, Luo W, Juhong Z, Yang J, Wang H, Zhou L and Chang J: Associations between genetic variations in the FURIN gene and hypertension. BMC Med Genet. 11:1242010. View Article : Google Scholar : PubMed/NCBI

29 

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, et al CARDIOGRAM, METASTROKE; LifeLines Cohort Study: Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 22:1663–1678. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Seidah NG, Khatib AM and Prat A: The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem. 387:871–877. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Choi S and Korstanje R: Proprotein convertases in high-density lipoprotein metabolism. Biomark Res. 1:272013. View Article : Google Scholar : PubMed/NCBI

32 

Franssen R, Visser ME, Kuivenhoven JA, et al: Role of lipoprotein lipase in triglyceride metabolism: Potential therapeutic target. Future Lipidol. 3:385–397. 2008. View Article : Google Scholar

33 

Galcheva-Gargova Z, Gangwani L, Konstantinov KN, Mikrut M, Theroux SJ, Enoch T and Davis RJ: The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Mol Biol Cell. 9:2963–2971. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Galcheva-Gargova Z, Konstantinov KN, Wu IH, Klier FG, Barrett T and Davis RJ: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. Science. 272:1797–1802. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Gangwani L: Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. J Biol Chem. 281:40330–40340. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Ahmad S, Wang Y, Shaik GM, Burghes AH and Gangwani L: The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. Hum Mol Genet. 21:2745–2758. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, et al: The nuclear receptor superfamily: The second decade. Cell. 83:835–839. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Corton JC, Anderson SP and Stauber A: Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol. 40:491–518. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Sladek FM, Zhong WM, Lai E and Darnell JE Jr: Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4((12B)): 2353–2365. 1990. View Article : Google Scholar : PubMed/NCBI

40 

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, et al Wellcome Trust Case Control Consortium: Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 30:2264–2276. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466:707–713. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Nakayama K, Yanagisawa Y, Ogawa A, Ishizuka Y, Munkhtulga L, Charupoonphol P, Supannnatas S, Kuartei S, Chimedregzen U, Koda Y, et al: High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia. J Hum Genet. 56:828–833. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, et al: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 41:56–65. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Abe S, Tokoro F, Matsuoka R, et al: Association of genetic variants with dyslipidemia. Mol Med Rep. (In press).

45 

Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, Rieder MJ, Cooper GM, Roos C, Voight BF, Havulinna AS, et al: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 40:189–197. 2008. View Article : Google Scholar

46 

Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, et al: Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet. 40:161–169. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Yan SK, Cheng XQ, Song YH, Xiao XH, Bi N and Chen BS: Apolipoprotein A5 gene polymorphism −1131T→C: Association with plasma lipids and type 2 diabetes mellitus with coronary heart disease in Chinese. Clin Chem Lab Med. 43:607–612. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Klos KL, Sing CF, Boerwinkle E, Hamon SC, Rea TJ, Clark A, Fornage M and Hixson JE: Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Arterioscler Thromb Vasc Biol. 26:1828–1836. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Ken-Dror G, Goldbourt U and Dankner R: Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins. J Hum Genet. 55:300–307. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Jakel H, Nowak M, Helleboid-Chapman A, Fruchart-Najib J and Fruchart JC: Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins? Ann Med. 38:2–10. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Garelnabi M, Lor K, Jin J, Chai F and Santanam N: The paradox of ApoA5 modulation of triglycerides: Evidence from clinical and basic research. Clin Biochem. 46:12–19. 2013. View Article : Google Scholar : PubMed/NCBI

52 

O'Brien PJ, Alborn WE, Sloan JH, Ulmer M, Boodhoo A, Knierman MD, Schultze AE and Konrad RJ: The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin Chem. 51:351–359. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Bernstein RM, Davis BM, Olefsky JM and Reaven GM: Hepatic insulin responsiveness in patients with endogenous hypertriglyceridaemia. Diabetologia. 14:249–253. 1978. View Article : Google Scholar : PubMed/NCBI

54 

Talmud PJ, Cooper JA, Hattori H, Miller IP, Miller GJ and Humphries SE: The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: Prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II. Diabetologia. 49:2337–2340. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Sóter MO, Gomes KB, Fernandes AP, Carvalho M, Pinheiro PS, Bosco AA, Silva DD and Sousa MO: −1131T>C and SW19 polymorphisms in APOA5 gene and lipid levels in type 2 diabetic patients. Mol Biol Rep. 39:7541–7548. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Tokoro F, Matsuoka R, Abe S, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, et al: Association of a genetic variant of the ZPR1 zinc finger gene with type 2 diabetes mellitus. Biomed Rep. 3:88–92. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ueyama C, Horibe H, Yamase Y, Fujimaki T, Oguri M, Kato K, Arai M, Watanabe S, Murohara T, Yamada Y, Yamada Y, et al: Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomed Rep 3: 641-647, 2015.
APA
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K. ... Yamada, Y. (2015). Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomedical Reports, 3, 641-647. https://doi.org/10.3892/br.2015.484
MLA
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Murohara, T., Yamada, Y."Association of FURIN and ZPR1 polymorphisms with metabolic syndrome". Biomedical Reports 3.5 (2015): 641-647.
Chicago
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Murohara, T., Yamada, Y."Association of FURIN and ZPR1 polymorphisms with metabolic syndrome". Biomedical Reports 3, no. 5 (2015): 641-647. https://doi.org/10.3892/br.2015.484
Copy and paste a formatted citation
x
Spandidos Publications style
Ueyama C, Horibe H, Yamase Y, Fujimaki T, Oguri M, Kato K, Arai M, Watanabe S, Murohara T, Yamada Y, Yamada Y, et al: Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomed Rep 3: 641-647, 2015.
APA
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K. ... Yamada, Y. (2015). Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomedical Reports, 3, 641-647. https://doi.org/10.3892/br.2015.484
MLA
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Murohara, T., Yamada, Y."Association of FURIN and ZPR1 polymorphisms with metabolic syndrome". Biomedical Reports 3.5 (2015): 641-647.
Chicago
Ueyama, C., Horibe, H., Yamase, Y., Fujimaki, T., Oguri, M., Kato, K., Arai, M., Watanabe, S., Murohara, T., Yamada, Y."Association of FURIN and ZPR1 polymorphisms with metabolic syndrome". Biomedical Reports 3, no. 5 (2015): 641-647. https://doi.org/10.3892/br.2015.484
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team