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Article

Proton pump inhibitors decrease melanogenesis in melanocytes

  • Authors:
    • Seung‑Hwa Baek
    • Sang‑Han Lee
  • View Affiliations / Copyright

    Affiliations: Department of Food Science and Biotechnology, Kyungpook National University, Daegu 702‑701, Republic of Korea
  • Pages: 726-730
    |
    Published online on: July 17, 2015
       https://doi.org/10.3892/br.2015.492
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Abstract

Proton pump inhibitors (PPIs) are widely used as inhibitors of gastric juice secretion for treatment of gastroesophageal reflux disease. However, there are no previous studies of the effects on melanogenesis resulting from PPI treatments. Therefore, the aim of the present study was to investigate the effects of PPIs on melanogenesis in melan‑a cells derived from immortalized mouse melanocytes. Tyrosinase activity and copper‑chelating activity were measured spectrophotometrically. In addition, the melanin content and viability of melan‑a cells treated with PPIs were assessed and the mRNA levels of melanogenesis‑associated genes were measured by reverse transcription‑polymerase chain reaction. Treatment with rabeprazole, but not the other PPIs tested, resulted in strong, dose‑dependent inhibition of mushroom tyrosinase (TYR). By contrast, each of the PPIs tested exhibited copper‑chelating activity. Treatment of melan‑a cells with 100 µM concentrations of the PPIs resulted in significantly reduced melanin synthesis and reduced expression of several melanogenesis‑associated genes, including TYR, TYR‑related protein‑1 (TRP‑1) and TRP‑2, and microphthalmia‑associated transcription factor, but did not result in cytotoxic effects. These results suggest that PPIs inhibit melanin biosynthesis in melan‑a cells via the downregulation of melanogenesis‑associated genes. Furthermore, the findings indicate that PPIs in general could be utilized as skin‑whitening agents and/or as biomaterial for treating hyperpigmentation disorders.
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1 

Jain KS, Shah AK, Bariwal J, Shelke SM, Kale AP, Jagtap JR and Bhosale AV: Recent advances in proton pump inhibitors and management of acid-peptic disorders. Bioorg Med Chem. 15:1181–1205. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Rew JS: Clinical use of proton pump inhibitors in gastrointestinal diseases. Korean J Gastroenterol. 47:181–190. 2006.PubMed/NCBI

3 

Shin JM, Lee JY, Lee DY, Yoon TY, Lee JC, Lim EH, Sohn KC, Lee YH, Im M, Seo YJ, et al: Proton pump inhibitors as a possible cause of vitiligo: An in vivo and in vitro study. J Eur Acad Dermatol Venereol. 28:1475–1479. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Namazi MR: Proton pump inhibitors may trigger vitiligo by rendering melanocytes prone to apoptosis. Br J Dermatol. 158:844–845. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Schallreuter KU and Rokos H: From the bench to the bedside: Proton pump inhibitors can worsen vitiligo. Br J Dermatol. 156:1371–1373. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Baek SH, Ahn JW, Nam SH, Yoon CS, Shin JC and Lee SH: S-(−)-10,11-dihydroxyfarnesoic acid methyl ester inhibits melanin synthesis in murine melanocyte cells. Int J Mol Sci. 15:12750–12763. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Pan T, Li X and Jankovic J: The association between Parkinson's disease and melanoma. Int J Cancer. 128:2251–2260. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Pan T, Zhu J, Hwu WJ and Jankovic J: The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PLoS One. 7:e451832012. View Article : Google Scholar : PubMed/NCBI

9 

Parvez S, Kang M, Chung HS and Bae H: Naturally occurring tyrosinase inhibitors: Mechanism and applications in skin health, cosmetics and agriculture industries. Phytother Res. 21:805–816. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kim JH, Baek SH, Kim DH, Choi TY, Yoon TJ, Hwang JS, Kim MR, Kwon HJ and Lee CH: Downregulation of melanin synthesis by haginin A and its application to in vivo lightening model. J Invest Dermatol. 128:1227–1235. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Matsui MS, Petris MJ, Niki Y, Karaman-Jurukovska N, Muizzuddin N, Ichihashi M and Yarosh DB: Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. J Invest Dermatol. 135:834–841. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Rao F, Yuting Z, Yiran G and Fang C: Antioxidant and tyrosinase inhibition activities of the ethanol-insoluble fraction of water extract of Sapium sebiferum (L.) Roxb. leaves. South Afr J Bot. 93:98–104. 2014. View Article : Google Scholar

13 

Bennett DC, Cooper PJ and Hart IR: A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth. Int J Cancer. 39:414–418. 1987. View Article : Google Scholar : PubMed/NCBI

14 

Heo JC and Lee SH: Alleviation of asthma-related symptoms by a derivative of L-allo threonine. Int J Mol Med. 31:881–887. 2013.PubMed/NCBI

15 

Chao HC, Najjaa H, Villareal MO, Ksouri R, Han J, Neffati M and Isoda H: Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells. Exp Dermatol. 22:131–136. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Beberok A, Wrześniok D, Otręba M and Buszman E: Impact of sparfloxacin on melanogenesis and antioxidant defense system in normal human melanocytes HEMa-LP - An in vitro study. Pharmacol Rep. 67:38–43. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Tuerxuntayi A, Liu YQ, Tulake A, Kabas M, Eblimit A and Aisa HA: Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells. BMC Complement Altern Med. 14:166–175. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Hachiya A, Kobayashi A, Ohuchi A, Takema Y and Imokawa G: The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation. J Invest Dermatol. 116:578–586. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Shin SH and Lee YM: Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways. Exp Mol Med. 45:e172013. View Article : Google Scholar : PubMed/NCBI

20 

Holla AP, Kumar R, Parsad D and Kanwar A: Proton pump inhibitor induced depigmentation in vitiligo. J Cutan Aesthet Surg. 4:46–47. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Shin JM and Sachs G: Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 10:528–534. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Baek SH and Lee SH: Proton pump inhibitors decrease melanogenesis in melanocytes. Biomed Rep 3: 726-730, 2015.
APA
Baek, S., & Lee, S. (2015). Proton pump inhibitors decrease melanogenesis in melanocytes. Biomedical Reports, 3, 726-730. https://doi.org/10.3892/br.2015.492
MLA
Baek, S., Lee, S."Proton pump inhibitors decrease melanogenesis in melanocytes". Biomedical Reports 3.5 (2015): 726-730.
Chicago
Baek, S., Lee, S."Proton pump inhibitors decrease melanogenesis in melanocytes". Biomedical Reports 3, no. 5 (2015): 726-730. https://doi.org/10.3892/br.2015.492
Copy and paste a formatted citation
x
Spandidos Publications style
Baek SH and Lee SH: Proton pump inhibitors decrease melanogenesis in melanocytes. Biomed Rep 3: 726-730, 2015.
APA
Baek, S., & Lee, S. (2015). Proton pump inhibitors decrease melanogenesis in melanocytes. Biomedical Reports, 3, 726-730. https://doi.org/10.3892/br.2015.492
MLA
Baek, S., Lee, S."Proton pump inhibitors decrease melanogenesis in melanocytes". Biomedical Reports 3.5 (2015): 726-730.
Chicago
Baek, S., Lee, S."Proton pump inhibitors decrease melanogenesis in melanocytes". Biomedical Reports 3, no. 5 (2015): 726-730. https://doi.org/10.3892/br.2015.492
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