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Article

Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease

  • Authors:
    • Serdal Arslan
    • Özge Korkmaz
    • Nil Özbilüm
    • Öcal Berkan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Biology, Cumhuriyet University, 58140 Sivas, Turkey, Department of Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University, 58140 Sivas, Turkey, Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, 58140 Sivas, Turkey
  • Pages: 736-740
    |
    Published online on: July 29, 2015
       https://doi.org/10.3892/br.2015.499
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Abstract

Coronary artery disease (CAD) is the leading cause of fatalities worldwide. Nuclear factor (NF)‑κB is a transcription factor that controls cell proliferation, differentiation and immunity. To the best of our knowledge, the present study is the first investigation of the association between CAD and NF‑κB1 ‑94 W/D/NF‑κBIA 3'‑untranslated region (3'‑UTR) A→G polymorphisms. The study population comprised 226 CAD patients and 201 controls. There was no significant difference in NF‑κB1A 3'‑UTR A→G in the allele and genotype frequencies between case and control populations. The D allele frequency of NF‑κB1 ‑94 in the case group was significantly higher compared to the control group (P=0.028, odds ratio=1.37). The genotype frequency of NF‑κB1 ‑94 DD in the case group was significantly higher compared to the controls (P=0.028). Linkage analysis showed a close linkage among these 2 genes (P<0.001 for case and control), and AD and GD haplotypes were associated with CAD (P<0.001; P=0.015, respectively). NF‑κB1 ‑94 DD genotype can be a significant risk factor for the development of CAD.
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Copy and paste a formatted citation
Spandidos Publications style
Arslan S, Korkmaz Ö, Özbilüm N and Berkan Ö: Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease. Biomed Rep 3: 736-740, 2015.
APA
Arslan, S., Korkmaz, Ö., Özbilüm, N., & Berkan, Ö. (2015). Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease. Biomedical Reports, 3, 736-740. https://doi.org/10.3892/br.2015.499
MLA
Arslan, S., Korkmaz, Ö., Özbilüm, N., Berkan, Ö."Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease". Biomedical Reports 3.5 (2015): 736-740.
Chicago
Arslan, S., Korkmaz, Ö., Özbilüm, N., Berkan, Ö."Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease". Biomedical Reports 3, no. 5 (2015): 736-740. https://doi.org/10.3892/br.2015.499
Copy and paste a formatted citation
x
Spandidos Publications style
Arslan S, Korkmaz Ö, Özbilüm N and Berkan Ö: Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease. Biomed Rep 3: 736-740, 2015.
APA
Arslan, S., Korkmaz, Ö., Özbilüm, N., & Berkan, Ö. (2015). Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease. Biomedical Reports, 3, 736-740. https://doi.org/10.3892/br.2015.499
MLA
Arslan, S., Korkmaz, Ö., Özbilüm, N., Berkan, Ö."Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease". Biomedical Reports 3.5 (2015): 736-740.
Chicago
Arslan, S., Korkmaz, Ö., Özbilüm, N., Berkan, Ö."Association between NF‑κBI and NF‑κBIA polymorphisms and coronary artery disease". Biomedical Reports 3, no. 5 (2015): 736-740. https://doi.org/10.3892/br.2015.499
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