Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
November-2015 Volume 3 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 3 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Age‑related changes in clinical parameters and their associations with common complex diseases

  • Authors:
    • Yoshiko Murakata
    • Tetsuo Fujimaki
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514‑8507, Japan, Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Mie 511‑0428, Japan
    Copyright: © Murakata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 767-777
    |
    Published online on: August 5, 2015
       https://doi.org/10.3892/br.2015.505
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to clarify the age‑related changes in 13 clinical parameters and their associations with common complex diseases. Study subjects comprised 6,027 community‑dwelling individuals who were recruited to a population‑based longitudinal genetic epidemiological study. Bonferroni's correction was applied to compensate for multiple comparisons of association and P<0.0011 was considered statistically significant. Body mass index and waist circumference increased with age up to ~50 years and decreased thereafter in men, whereas the two parameters increased linearly with age in women. The prevalence of obesity was highest (41.1%) in men aged 40‑49 years, after which it decreased with age. The prevalence of obesity in women increased with age to ≤32.2% in those aged ≥70 years. Systolic and mean blood pressure (BP), as well as pulse pressure, increased linearly with age in all subjects, whereas diastolic BP increased with age up to ~60 years and subsequently decreased. The prevalence of hypertension increased with age to ≤69.9 or 68.5% at age ≥70 years in men and women, respectively. The fasting plasma glucose level, blood hemoglobin A1c content and the prevalence of type 2 diabetes mellitus increased gradually with age in men and women. The serum triglyceride concentration increased with age up to ~50 years and decreased thereafter in men, whereas it increased linearly with age in women. The prevalence of hypertriglyceridemia increased to a peak of 56.8% at age 50‑59 years and subsequently decreased in men, whereas in women it increased with age to ≤34.9% at ≥70 years. The serum high‑density lipoprotein (HDL)‑cholesterol concentration increased with age up to ~50 years and decreased thereafter in women. The prevalence of hypo‑HDL‑cholesterolemia increased gradually with age in women. The serum concentration of low‑density lipoprotein (LDL)‑cholesterol increased with age up to ~50 years and subsequently declined in men, whereas it increased linearly with age in women. The prevalence of hyper‑LDL‑cholesterolemia increased with age to ≤53.4% at 50‑59 years in men and ≤63.9% at 60‑69 years in women and it decreased thereafter in the two genders. The serum creatinine concentration and the estimated glomerular filtration rate increased or decreased linearly with age, respectively. The prevalence of chronic kidney disease (CKD) increased with age to ≤45.1 or 39.6% at ≥70 years in men and women, respectively. Therefore, these results indicate that 13 clinical parameters, as well as the prevalence of obesity, hypertension, type 2 diabetes mellitus, dyslipidemia and CKD, were significantly associated with age. They may therefore prove informative for the prevention of these diseases and contribute to the achievement of a healthy long life and successful aging.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Figure 14

View References

1 

Nigam Y, Knight J, Bhattacharya S and Bayer A: Physiological changes associated with aging and immobility. J Aging Res. 2012:4684692012. View Article : Google Scholar : PubMed/NCBI

2 

Barford A, Dorling D, Davey Smith G and Shaw M: Life expectancy: Women now on top everywhere. BMJ. 332:8082006. View Article : Google Scholar : PubMed/NCBI

3 

Martin P, Poon LW and Hagberg B: Behavioral factors of longevity. J Aging Res. 2011:1975902011. View Article : Google Scholar : PubMed/NCBI

4 

Rosenthal RA and Kavic SM: Assessment and management of the geriatric patient. Crit Care Med. 32 (Suppl 4):S92–S105. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Dodds C: Physiology of ageing. Anaesth Intensive Care Med. 7:456–458. 2006. View Article : Google Scholar

6 

Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. Int J Mol Med. 35:1189–1198. 2015.PubMed/NCBI

7 

Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants of the alpha-kinase 1 gene with type 2 diabetes mellitus in a longitudinal population-based genetic epidemiological study. Biomed Rep. 3:347–354. 2015.PubMed/NCBI

8 

Yamada Y, Matsui K, Takeuchi I and Fujimaki T: Association of genetic variants with dyslipidemia and chronic kidney disease in a longitudinal population-based genetic epidemiological study. Int J Mol Med. 35:1290–1300. 2015.PubMed/NCBI

9 

Yamada Y, Matsui K, Takeuchi I and Fujimaki T: Association of genetic variants with coronary artery disease and ischemic stroke in a longitudinal population-based genetic epidemiological study. Biomed Rep. 3:413–419. 2015.PubMed/NCBI

10 

Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P and Inoue S: Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pac J Clin Nutr. 11 (Suppl 8):S732–S737. 2002. View Article : Google Scholar

11 

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H and Hishida A: Collaborators developing the Japanese equation for estimated GFR: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992. 2009. View Article : Google Scholar : PubMed/NCBI

12 

National Kidney Foundation, . K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 39 (Suppl 1):S1–S266. 2002.PubMed/NCBI

13 

Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS and Koplan JP: The continuing epidemics of obesity and diabetes in the United States. JAMA. 286:1195–1200. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Flegal KM, Carroll MD, Ogden CL and Johnson CL: Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 288:1723–1727. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR and Flegal KM: Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA. 291:2847–2850. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH and Speizer FE: Body weight and mortality among women. N Engl J Med. 333:677–685. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Kannel WB, Gordon T and Castelli WP: Obesity, lipids, and glucose intolerance. The Framingham Study. Am J Clin Nutr. 32:1238–1245. 1979.PubMed/NCBI

18 

Rissanen A, Heliövaara M and Aromaa A: Overweight and anthropometric changes in adulthood: A prospective study of 17,000 Finns. Int J Obes. 12:391–401. 1988.PubMed/NCBI

19 

Grinker JA, Tucker K, Vokonas PS and Rush D: Body habitus changes among adult males from the normative aging study: Relations to aging, smoking history and alcohol intake. Obes Res. 3:435–446. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Poehlman ET, Toth MJ, Bunyard LB, Gardner AW, Donaldson KE, Colman E, Fonong T and Ades PA: Physiological predictors of increasing total and central adiposity in aging men and women. Arch Intern Med. 155:2443–2448. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Villareal DT, Apovian CM, Kushner RF and Klein S: American Society for Nutrition; NAASO, The Obesity Society: Obesity in older adults: Technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr. 82:923–934. 2005.PubMed/NCBI

22 

Baumgartner RN, Stauber PM, McHugh D, Koehler KM and Garry PJ: Cross-sectional age differences in body composition in persons 60+ years of age. J Gerontol A Biol Sci Med Sci. 50:M307–M316. 1995. View Article : Google Scholar : PubMed/NCBI

23 

Gallagher D, Visser M, De Meersman RE, Sepúlveda D, Baumgartner RN, Pierson RN, Harris T and Heymsfield SB: Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. J Appl Physiol (1985). 83:229–239. 1997.PubMed/NCBI

24 

Beaufrère B and Morio B: Fat and protein redistribution with aging: Metabolic considerations. Eur J Clin Nutr. 54 (Suppl 3):S48–S53. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Hallfrisch J, Muller D, Drinkwater D, Tobin J and Andres R: Continuing diet trends in men: The Baltimore Longitudinal Study of Aging (1961–1987). J Gerontol. 45:M186–M191. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Garry PJ, Hunt WC, Koehler KM, Vander Jagt DJ and Vellas BJ: Longitudinal study of dietary intakes and plasma lipids in healthy elderly men and women. Am J Clin Nutr. 55:682–688. 1992.PubMed/NCBI

27 

Elia M, Ritz P and Stubbs RJ: Total energy expenditure in the elderly. Eur J Clin Nutr. 54 (Suppl 3):S92–S103. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Williamson DF, Madans J, Anda RF, Kleinman JC, Kahn HS and Byers T: Recreational physical activity and ten-year weight change in a US national cohort. Int J Obes Relat Metab Disord. 17:279–286. 1993.PubMed/NCBI

29 

Franklin SS: Ageing and hypertension: The assessment of blood pressure indices in predicting coronary heart disease. J Hypertens Suppl. 17:S29–S36. 1999.PubMed/NCBI

30 

Staessen JA, Gasowski J, Wang JG, Thijs L, Den Hond E, Boissel JP, Coope J, Ekbom T, Gueyffier F, Liu L, et al: Risks of untreated and treated isolated systolic hypertension in the elderly: Meta-analysis of outcome trials. Lancet. 355:865–872. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Lewington S, Clarke R, Qizilbash N, Peto R and Collins R: Prospective Studies Collaboration: Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 360:1903–1913. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Pinto E: Blood pressure and ageing. Postgrad Med J. 83:109–114. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Chang AM and Halter JB: Aging and insulin secretion. Am J Physiol Endocrinol Metab. 284:E7–E12. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Stumvoll M, Goldstein BJ and van Haeften TW: Type 2 diabetes: Principles of pathogenesis and therapy. Lancet. 365:1333–1346. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Stout RW: Glucose tolerance and ageing. J R Soc Med. 87:608–609. 1994.PubMed/NCBI

36 

Shimokata H, Muller DC, Fleg JL, Sorkin J, Ziemba AW and Andres R: Age as independent determinant of glucose tolerance. Diabetes. 40:44–51. 1991. View Article : Google Scholar : PubMed/NCBI

37 

Fink RI, Kolterman OG, Griffin J and Olefsky JM: Mechanisms of insulin resistance in aging. J Clin Invest. 71:1523–1535. 1983. View Article : Google Scholar : PubMed/NCBI

38 

Rowe JW, Minaker KL, Pallotta JA and Flier JS: Characterization of the insulin resistance of aging. J Clin Invest. 71:1581–1587. 1983. View Article : Google Scholar : PubMed/NCBI

39 

Rosenthal M, Doberne L, Greenfield M, Widstrom A and Reaven GM: Effect of age on glucose tolerance, insulin secretion, and in vivo insulin action. J Am Geriatr Soc. 30:562–567. 1982. View Article : Google Scholar : PubMed/NCBI

40 

Reaven G: Age and glucose intolerance: Effect of fitness and fatness. Diabetes Care. 26:539–540. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Kuzuya M, Ando F, Iguchi A and Shimokata H: Changes in serum lipid levels during a 10 year period in a large Japanese population. A cross-sectional and longitudinal study. Atherosclerosis. 163:313–320. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Kuzuya M, Ando F, Iguchi A and Shimokata H: Effect of smoking habit on age-related changes in serum lipids: A cross-sectional and longitudinal analysis in a large Japanese cohort. Atherosclerosis. 185:183–190. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Liu HH and Li JJ: Aging and dyslipidemia: A review of potential mechanisms. Ageing Res Rev. 19:43–52. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Zhou XJ, Rakheja D, Yu X, Saxena R, Vaziri ND and Silva FG: The aging kidney. Kidney Int. 74:710–720. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Weinstein JR and Anderson S: The aging kidney: Physiological changes. Adv Chronic Kidney Dis. 17:302–307. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Yamagata K, Ishida K, Sairenchi T, Takahashi H, Ohba S, Shiigai T, Narita M and Koyama A: Risk factors for chronic kidney disease in a community-based population: A 10-year follow-up study. Kidney Int. 71:159–166. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F and Levey AS: Prevalence of chronic kidney disease in the United States. JAMA. 298:2038–2047. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Murakata Y, Fujimaki T and Yamada Y: Age‑related changes in clinical parameters and their associations with common complex diseases. Biomed Rep 3: 767-777, 2015.
APA
Murakata, Y., Fujimaki, T., & Yamada, Y. (2015). Age‑related changes in clinical parameters and their associations with common complex diseases. Biomedical Reports, 3, 767-777. https://doi.org/10.3892/br.2015.505
MLA
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3.6 (2015): 767-777.
Chicago
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3, no. 6 (2015): 767-777. https://doi.org/10.3892/br.2015.505
Copy and paste a formatted citation
x
Spandidos Publications style
Murakata Y, Fujimaki T and Yamada Y: Age‑related changes in clinical parameters and their associations with common complex diseases. Biomed Rep 3: 767-777, 2015.
APA
Murakata, Y., Fujimaki, T., & Yamada, Y. (2015). Age‑related changes in clinical parameters and their associations with common complex diseases. Biomedical Reports, 3, 767-777. https://doi.org/10.3892/br.2015.505
MLA
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3.6 (2015): 767-777.
Chicago
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3, no. 6 (2015): 767-777. https://doi.org/10.3892/br.2015.505
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team