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Article

Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension

  • Authors:
    • Guozhen Yan
    • Junfeng He
    • Yueli Yu
    • Yang Liu
    • Yanfen Yuan
    • Zhiyong Guo
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014010, P.R. China
  • Pages: 51-54
    |
    Published online on: October 6, 2015
       https://doi.org/10.3892/br.2015.526
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Abstract

The continuous changes in pulmonary hemodynamic properties in hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) have not been fully characterized in large animal models of HPS and PoPH. Beagle dog models of HPS and PoPH were induced by chronic common bile duct ligation and Sephadex microspheres, respectively. The model was validated by catheter examination and pathological analyses, and the hemodynamic characteristics of the models were observed. The results revealed that the cross‑sectional area of the blood vessel was significantly increased in HPS models, but it was significantly decreased in the PoPH models. Furthermore, the resistance of pulmonary circulation was elevated in models of HPS, but it was decreased in models of PoPH. The present findings renew the traditional view that pulmonary hypertension is due to the enhanced peripheral resistance.
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Copy and paste a formatted citation
Spandidos Publications style
Yan G, He J, Yu Y, Liu Y, Yuan Y and Guo Z: Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomed Rep 4: 51-54, 2016.
APA
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., & Guo, Z. (2016). Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomedical Reports, 4, 51-54. https://doi.org/10.3892/br.2015.526
MLA
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., Guo, Z."Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension". Biomedical Reports 4.1 (2016): 51-54.
Chicago
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., Guo, Z."Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension". Biomedical Reports 4, no. 1 (2016): 51-54. https://doi.org/10.3892/br.2015.526
Copy and paste a formatted citation
x
Spandidos Publications style
Yan G, He J, Yu Y, Liu Y, Yuan Y and Guo Z: Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomed Rep 4: 51-54, 2016.
APA
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., & Guo, Z. (2016). Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomedical Reports, 4, 51-54. https://doi.org/10.3892/br.2015.526
MLA
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., Guo, Z."Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension". Biomedical Reports 4.1 (2016): 51-54.
Chicago
Yan, G., He, J., Yu, Y., Liu, Y., Yuan, Y., Guo, Z."Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension". Biomedical Reports 4, no. 1 (2016): 51-54. https://doi.org/10.3892/br.2015.526
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