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Article

ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4

  • Authors:
    • Cenqi Guo
    • Anastasia Tsigkou
    • Meng Huee Lee
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Xian Jiaotong‑Liverpool University, Suzhou, Jiangsu 215123, P.R. China
  • Pages: 73-78
    |
    Published online on: October 30, 2015
       https://doi.org/10.3892/br.2015.535
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Abstract

A disintegrin and metalloproteinase with thombospondin motifs (ADAMTS) 13 and 15 are secreted zinc proteinases involved in the turnover of von Willebrand factor and cancer suppression. In the present study, ADAMTS13 and 15 were subjected to inhibition studies with the full‑length and N‑terminal domain forms of tissue inhibitor of metalloproteinases (TIMPs)‑1 to ‑4. TIMPs have no ability to inhibit the ADAMTS proteinases in the full‑length or N‑terminal domain form. While ADAMTS13 is also not sensitive to the hydroxamate inhibitors, batimastat and ilomastat, ADAMTS15 can be effectively inhibited by batimastat (Kiapp 299 nM). In conclusion, the present results indicate that TIMPs are not the regulators of these two ADAMTS proteinases.
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Copy and paste a formatted citation
Spandidos Publications style
Guo C, Tsigkou A and Lee MH: ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4. Biomed Rep 4: 73-78, 2016.
APA
Guo, C., Tsigkou, A., & Lee, M.H. (2016). ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4. Biomedical Reports, 4, 73-78. https://doi.org/10.3892/br.2015.535
MLA
Guo, C., Tsigkou, A., Lee, M. H."ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4". Biomedical Reports 4.1 (2016): 73-78.
Chicago
Guo, C., Tsigkou, A., Lee, M. H."ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4". Biomedical Reports 4, no. 1 (2016): 73-78. https://doi.org/10.3892/br.2015.535
Copy and paste a formatted citation
x
Spandidos Publications style
Guo C, Tsigkou A and Lee MH: ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4. Biomed Rep 4: 73-78, 2016.
APA
Guo, C., Tsigkou, A., & Lee, M.H. (2016). ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4. Biomedical Reports, 4, 73-78. https://doi.org/10.3892/br.2015.535
MLA
Guo, C., Tsigkou, A., Lee, M. H."ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4". Biomedical Reports 4.1 (2016): 73-78.
Chicago
Guo, C., Tsigkou, A., Lee, M. H."ADAMTS13 and 15 are not regulated by the full length and N‑terminal domain forms of TIMP‑1, ‑2, ‑3 and ‑4". Biomedical Reports 4, no. 1 (2016): 73-78. https://doi.org/10.3892/br.2015.535
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