Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer

Zhu,Jingfeng; Liu,Chao; Teng,Xiao; Yin,Jun; Zheng,Liang; Wang,Liming; Tang,Weifeng; Gu,Haiyong; Gu,Bing; Chen,Liang

doi:10.3892/br.2015.552

Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer

Authors:
- Jingfeng Zhu
- Chao Liu
- Xiao Teng
- Jun Yin
- Liang Zheng
- Liming Wang
- Weifeng Tang
- Haiyong Gu
- Bing Gu
- Liang Chen
View Affiliations

Affiliations: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R. China, Department of Cardiothoracic Surgery, The First People's Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu 213003, P.R. China, Cancer Institute, Department of Chemotherapy, People's Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China, Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221000, P.R. China, Department of Thoracic and Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China
Published online on: December 7, 2015 https://doi.org/10.3892/br.2015.552
Pages: 227-235

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Esophageal cancer is the fourth leading cause of cancer-associated fatalities and the fourth most commonly diagnosed cancer. In addition to environmental risk factors, genetic factors may have a significant role in esophageal cancer carcinogenesis. A hospital‑based case‑control study was conducted to evaluate the genetic effects of functional single‑nucleotide polymorphisms in the interleukin‑18 (IL‑18), IL‑18 receptor 1 protein (IL‑18R1), IL‑18 receptor accessory protein (IL‑18RAP) and IL‑28B on the development of esophageal cancer. In total, 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for the present study. The IL‑18 rs360719 A>G, IL‑18R1 rs13015714 G>T, IL‑18RAP rs917997 C>T and IL‑28B rs8099917 T>G genotypes were determined. No association was observed between the IL‑18R1 rs13015714 G>T, IL‑18RAP rs917997 C>T and IL‑28B rs8099917 T>G polymorphisms and the risk of ESCC. However, in stratification analyses, a significantly decreased risk of ESCC associated with the IL‑18R1 rs13015714 G>T polymorphism and a significantly increased risk of ESCC associated with the IL‑18RAP rs917997 C>T polymorphism was evident among male patients and patients who smoked or consumed alcohol. These findings highlighted that functional polymorphisms IL‑18R1 rs13015714 G>T and IL‑18RAP rs917997 C>T may contribute to ESCC susceptibility among these subgroups. However, the present results were obtained with a limited sample size and further epidemiological studies are warranted to clarify the role of IL-18R1 and IL-18RAP variants in the development of ESCC.

View Figures

View References

1	Chen W, Zheng R, Zhang S, et al: Annual report on status of cancer in China, 2010. Chin J Cancer Res. 26:48–58. 2014.PubMed/NCBI
2	Berrino F, De Angelis R, Sant M, Rosso S, Bielska-Lasota M, Coebergh JW and Santaquilani M: EUROCARE Working group Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: Results of the EUROCARE-4 study. Lancet Oncol. 8:773–783. 2007. View Article : Google Scholar : PubMed/NCBI
3	Macfarlane GJ and Boyle P: The epidemiology of oesophageal cancer in the UK and other European countries. J R Soc Med. 87:334–337. 1994.PubMed/NCBI
4	Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
5	Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI
6	Sun JM, Li Q, Gu HY, Chen YJ, Wei JS, Zhu Q and Chen L: Interleukin 10 rs1800872 T>G polymorphism was associated with an increased risk of esophageal cancer in a Chinese population. Asian Pac J Cancer Prev. 14:3443–3447. 2013. View Article : Google Scholar : PubMed/NCBI
7	Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE and Nakanishi K: IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci USA. 96:13962–13966. 1999. View Article : Google Scholar : PubMed/NCBI
8	Zitvogel L, Kepp O, Galluzzi L and Kroemer G: Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol. 13:343–351. 2012. View Article : Google Scholar : PubMed/NCBI
9	Born TL, Thomassen E, Bird TA and Sims JE: Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 273:29445–29450. 1998. View Article : Google Scholar : PubMed/NCBI
10	Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, et al: Purification and characterization of the human interleukin-18 receptor. J Biol Chem. 272:25737–25742. 1997. View Article : Google Scholar : PubMed/NCBI
11	Salcedo R, Worschech A, Cardone M, et al: MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18. J Exp Med. 207:1625–1636. 2010. View Article : Google Scholar : PubMed/NCBI
12	Cheung H, Chen NJ, Cao Z, Ono N, Ohashi PS and Yeh WC: Accessory protein-like is essential for IL-18-mediated signaling. J Immunol. 174:5351–5357. 2005. View Article : Google Scholar : PubMed/NCBI
13	Sareneva T, Julkunen I and Matikainen S: IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J Immunol. 165:1933–1938. 2000. View Article : Google Scholar : PubMed/NCBI
14	Zhernakova A, Festen EM, Franke L, et al: Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet. 82:1202–1210. 2008. View Article : Google Scholar : PubMed/NCBI
15	Thompson SR and Humphries SE: Interleukin-18 genetics and inflammatory disease susceptibility. Genes Immun. 8:91–99. 2007. View Article : Google Scholar : PubMed/NCBI
16	Sánchez E, Palomino-Morales RJ, Ortego-Centeno N, Jiménez-Alonso J, González-Gay MA, López-Nevot MA, Sánchez-Román J, de Ramón E, González-Escribano MF, Pons-Estel BA, et al: Italian collaborative group: Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus. Hum Mol Genet. 18:3739–3748. 2009. View Article : Google Scholar : PubMed/NCBI
17	Koskinen LL, Einarsdottir E, Dukes E, Heap GA, Dubois P, Korponay-Szabo IR, Kaukinen K, Kurppa K, Ziberna F, Vatta S, et al: Association study of the IL18RAP locus in three European populations with coeliac disease. Hum Mol Genet. 18:1148–1155. 2009. View Article : Google Scholar : PubMed/NCBI
18	Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, Bassendine M, Spengler U, Dore GJ, Powell E, et al: IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 41:1100–1104. 2009. View Article : Google Scholar : PubMed/NCBI
19	Eurich D, Boas-Knoop S, Ruehl M, Schulz M, Carrillo ED, Berg T, Neuhaus R, Neuhaus P, Neumann UP and Bahra M: Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus-induced graft inflammation and the response to antiviral therapy after liver transplantation. Liver Transpl. 17:289–298. 2011. View Article : Google Scholar : PubMed/NCBI
20	Chen X, Li S, Yang Y, Yang X, Liu Y, Liu Y, Hu W, Jin L and Wang X: Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J Thromb Haemost. 10:1508–1514. 2012. View Article : Google Scholar : PubMed/NCBI
21	Babar M, Ryan AW, Anderson LA, Segurado R, Turner G, Murray LJ, Murphy SJ, Johnston BT, Comber H, Reynolds JV, et al: Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. Am J Gastroenterol. 107:1331–1341. 2012. View Article : Google Scholar : PubMed/NCBI
22	Spielman RS, Bastone LA, Burdick JT, Morley M, Ewens WJ and Cheung VG: Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet. 39:226–231. 2007. View Article : Google Scholar : PubMed/NCBI