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Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse

  • Authors:
    • Fenfen Fu
    • Xi Xiao
    • Tao Zhang
    • Qiongyan Zou
    • Zonglin Chen
    • Lei Pei
    • Juan Su
    • Wenjun Yi
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Thyroid Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 167-172
    |
    Published online on: January 8, 2016
       https://doi.org/10.3892/br.2016.570
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Abstract

Patients with triple negative breast cancer (TNBC) have a higher rate of distant recurrence and a poorer prognosis than those with other breast cancer subtypes. Therefore, it is important to study the mechanism of TNBC relapse. A retrospective immunohistochemical analysis of the expression of receptor protein tyrosine phosphatase ζ (PTPRZ1) and pleiotrophin (PTN) was performed for 325 cases of breast cancer. These samples included 66 cases of luminal A breast cancer, 67 cases of luminal B breast cancer, 78 cases of Her‑2‑enriched breast cancer, 78 cases of TNBC and 36 cases of relapsed TNBC (RTNBC). In addition, 30 control specimens and 30 cases of metastasized lymph nodes were examined. PTPRZ1 and PTN were highly expressed in the RTNBC group. Compared with the RTNBC group, significant differences in the expression of PTPRZ1 were observed between the TNBC, BC and control groups. A significant difference was observed in the expression of PTN in the BC group (P<0.05) compared to RTNBC, and there were no significant differences in the expression of PTPRZ1 and PTN among the molecular subtypes. No significant correlation was observed between the expression of PTPRZ1, PTN, ER, PR, Her‑2 and ALN and the tumor size or menopause status. No significant correlation was identified between the expression of PTPRZ1 and PTN and the expression of CD24 and CD44. In summary, high expression of PTPRZ1 may be an independent risk indicator for TNBC recurrence and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Fu F, Xiao X, Zhang T, Zou Q, Chen Z, Pei L, Su J and Yi W: Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse. Biomed Rep 4: 167-172, 2016.
APA
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L. ... Yi, W. (2016). Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse. Biomedical Reports, 4, 167-172. https://doi.org/10.3892/br.2016.570
MLA
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L., Su, J., Yi, W."Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse". Biomedical Reports 4.2 (2016): 167-172.
Chicago
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L., Su, J., Yi, W."Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse". Biomedical Reports 4, no. 2 (2016): 167-172. https://doi.org/10.3892/br.2016.570
Copy and paste a formatted citation
x
Spandidos Publications style
Fu F, Xiao X, Zhang T, Zou Q, Chen Z, Pei L, Su J and Yi W: Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse. Biomed Rep 4: 167-172, 2016.
APA
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L. ... Yi, W. (2016). Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse. Biomedical Reports, 4, 167-172. https://doi.org/10.3892/br.2016.570
MLA
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L., Su, J., Yi, W."Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse". Biomedical Reports 4.2 (2016): 167-172.
Chicago
Fu, F., Xiao, X., Zhang, T., Zou, Q., Chen, Z., Pei, L., Su, J., Yi, W."Expression of receptor protein tyrosine phosphatase ζ is a risk factor for triple negative breast cancer relapse". Biomedical Reports 4, no. 2 (2016): 167-172. https://doi.org/10.3892/br.2016.570
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