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Review

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)

  • Authors:
    • Maria Aparecida Nagai
  • View Affiliations / Copyright

    Affiliations: Discipline of Oncology, Department of Radiology, Faculty of Medicine, University of São Paulo, Laboratory of Molecular Genetics, Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, SP 01246‑000, Brazil
  • Pages: 275-281
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    Published online on: January 25, 2016
       https://doi.org/10.3892/br.2016.580
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Abstract

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) encodes a member of an evolutionarily conserved pleckstrin homology‑related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation‑induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of PHLDA1 remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Nagai MA: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomed Rep 4: 275-281, 2016.
APA
Nagai, M.A. (2016). Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomedical Reports, 4, 275-281. https://doi.org/10.3892/br.2016.580
MLA
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4.3 (2016): 275-281.
Chicago
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4, no. 3 (2016): 275-281. https://doi.org/10.3892/br.2016.580
Copy and paste a formatted citation
x
Spandidos Publications style
Nagai MA: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomed Rep 4: 275-281, 2016.
APA
Nagai, M.A. (2016). Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomedical Reports, 4, 275-281. https://doi.org/10.3892/br.2016.580
MLA
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4.3 (2016): 275-281.
Chicago
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4, no. 3 (2016): 275-281. https://doi.org/10.3892/br.2016.580
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