Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
March-2016 Volume 4 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2016 Volume 4 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion

  • Authors:
    • Yanxia Zhang
    • Jufang Guo
    • Chuan Lin
    • Lu Lu
    • Chengzhi Li
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Ultrasound Engineering in Medicine Co‑founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 340-344
    |
    Published online on: January 25, 2016
       https://doi.org/10.3892/br.2016.581
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of low‑intensity focused ultrasound on endothelin‑1 (ET‑1), nitrogen monoxide (NO) and oxytocin receptor (OXTR) levels in the uterine tissues of Sprague-Dawley (SD) rats following abortion. A total of 30 SD rats undergoing complete abortion were randomly divided into ultrasound irradiation and sham irradiation groups (15 rats per group). The rats in the ultrasound irradiation group were treated with low‑intensity ultrasound (sound intensity, 2 W/cm2; frequency, 0.8 MHz) for 30 min daily for 5 consecutive days, and those in the sham irradiation group received sham treatment. The uterine tissue was removed to measure the levels of ET‑1, NO and OXTR using the enzyme‑linked immunosorbent assay and immunohistochemistry, respectively. The ET‑1 level in the uterine tissues was significantly higher in the ultrasound irradiation group compared to the sham irradiation group (P<0.05); however, the NO level was similar in the 2 groups (P>0.05). In the uterine myometrium and endometrium, the strong positive expression of OXTR was observed in the ultrasound irradiation group, which was significantly higher compared to the sham irradiation group (P<0.05). Low‑intensity ultrasound could promote uterine involution by increasing ET‑1 levels, modifying the balance of ET‑1 and NO, and enhancing the expression of OXTR in the uterine myometrium and endometrium.
View Figures

Figure 1

Figure 2

View References

1 

Menetrey J, Kasemkijwattana C, Fu FH, Moreland MS and Huard J: Suturing versus immobilization of a muscle laceration. A morphological and functional study in a mouse model. Am J Sports Med. 27:222–229. 1999.PubMed/NCBI

2 

Li Y, Shao L, Li S, Deng Z and Zhu C: Experimental observation on the Pessaries for the identification of pregnant rat model. Chinese Journal of Laboratory Animal Science. 1:62002.

3 

You Z, Zeng J, You H, Zha Y, Deng H and Li D: Effect of gynecology hemostasis acesodyne granule on the expression of estrogen-progestin and its receptor in rats model of medical abortion. Chinese Journal of Information on Traditional Chinese Medicine. 17:19–21. 2010.

4 

Wu Z, Zeng Y and Zhu L: Analysis of 238 cases postpartum subinvolution of uterus. The Modern Medicine. 11:41–42. 2011.

5 

Heinemann U: Basic mechanisms of partial epilepsies. Curr Opin Neurol. 17:155–159. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Yang J, Yang T and Cui X: Effect of Sheng Hua Tang to the level of NO and ET-1 in abortion rat model. Journal of Liaoning Traditional Chinese Medicine. 11:2002–2003. 2009.

7 

Dallot E, Pouchelet M, Gouhier N, Cabrol D, Ferré F and Breuiller-Fouché M: Contraction of cultured human uterine smooth muscle cells after stimulation with endothelin-1. Biol Reprod. 68:937–942. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Di Liberto G, Dallot E, Eude-Le Parco I, Cabrol D, Ferré F and Breuiller-Fouché M: A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy. Am J Physiol Cell Physiol. 285:C599–C607. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Tanfin Z, Leiber D, Robin P, Oyeniran C and Breuiller-Fouché M: Endothelin-1: Physiological and pathological roles in myometrium. Int J Biochem Cell Biol. 43:299–302. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Buhimschi I, Yallampalli C, Dong Y-L and Garfield RE: Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of human uterine contractility during pregnancy. Am J Obstet Gynecol. 172:1577–1584. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Anggård EE: Endogenous and exogenous nitrates. Acta Anaesthesiol Scand Suppl. 97:7–10. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Robinson KJ, Hazon N, Lonergan M and Pomeroy PP: Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure. J Neurosci Methods. 226:73–79. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Neumann ID and Landgraf R: Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors. Trends Neurosci. 35:649–659. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Liu Q, Qian DM, Liu QL and Gao H: Research progress of oxytocin and its analogues. Chin J Pharm Anal. 31:609–613. 2011.

15 

Murata T, Narita K and Ichimaru T: Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors. J Reprod Dev. 60:55–61. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Jia R and Liu X: Effects of oxytocin and prostaglandins on oxytocin receptor expression of human myometrial smooth muscle cell. Chin J Biochem Pharmaceuties. 30:379–382. 2009.

17 

Magalhaes JK, Carvalho JC, Parkes RK, Kingdom J, Li Y and Balki M: Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci. 16:501–508. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Haar Ter G, Dyson M and Talbert D: Ultrasonically induced contractions in mouse uterine smooth muscle in vivo. Ultrasonics. 16:275–276. 1978. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Y, Sun JC, Chang SF, Wang ZB, Wang GZ and Liu YM: Dose effect of low intensity ultrasound on uterine smooth muscle in rats. Acta Academiae Medicinae Militaris Tertiae. 16:1566–1568. 2007.

20 

Rui-Hong L, Jiangchuan S and Shufang C: The effect of low intensity ultrasound on the contraction of uterine smooth muscle in rats in vivo. Journal of Chongqing Medical University. 6:162008.

21 

Zhang Y, Sun JC, Chang SF and Wang ZB: A comparative study: Low intensity ultrasound and oxytocin on the contraction of uterine smooth muscle in rats. Chinese Journal of Medical Imaging Technology. 2:22008.

22 

Romero R, Sibai BM, Sanchez-Ramos L, Valenzuela GJ, Veille JC, Tabor B, Perry KG, Varner M, Goodwin TM, Lane R, et al: An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: A randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol. 182:1173–1183. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Guo J, Lin C, Lu L and Li C: Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion. Biomed Rep 4: 340-344, 2016.
APA
Zhang, Y., Guo, J., Lin, C., Lu, L., & Li, C. (2016). Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion. Biomedical Reports, 4, 340-344. https://doi.org/10.3892/br.2016.581
MLA
Zhang, Y., Guo, J., Lin, C., Lu, L., Li, C."Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion". Biomedical Reports 4.3 (2016): 340-344.
Chicago
Zhang, Y., Guo, J., Lin, C., Lu, L., Li, C."Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion". Biomedical Reports 4, no. 3 (2016): 340-344. https://doi.org/10.3892/br.2016.581
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Guo J, Lin C, Lu L and Li C: Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion. Biomed Rep 4: 340-344, 2016.
APA
Zhang, Y., Guo, J., Lin, C., Lu, L., & Li, C. (2016). Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion. Biomedical Reports, 4, 340-344. https://doi.org/10.3892/br.2016.581
MLA
Zhang, Y., Guo, J., Lin, C., Lu, L., Li, C."Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion". Biomedical Reports 4.3 (2016): 340-344.
Chicago
Zhang, Y., Guo, J., Lin, C., Lu, L., Li, C."Effect of low-intensity focused ultrasound on endothelin-1, nitrogen monoxide and oxytocin receptor in the uterine tissues of Sprague-Dawley rats following abortion". Biomedical Reports 4, no. 3 (2016): 340-344. https://doi.org/10.3892/br.2016.581
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team