Analysis of drug resistance in 1,861 strains of Acinetobacter baumannii

Jin,Hao; Qiu,Fan; Ji,Hong  Jian; Lu,Qiang

doi:10.3892/br.2016.598

April-2016 Volume 4 Issue 4

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April-2016 Volume 4 Issue 4

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Article

Analysis of drug resistance in 1,861 strains of Acinetobacter baumannii

Authors:
- Hao Jin
- Fan Qiu
- Hong Jian Ji
- Qiang Lu
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory, Yancheng Third People's Hospital, Yancheng, Jiangsu 224005, P.R. China, Department of Pharmacy, Yancheng Vocational Institute of Health Science, Yancheng, Jiangsu 224005, P.R. China
Pages: 463-466
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Published online on: February 15, 2016

https://doi.org/10.3892/br.2016.598
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Abstract

Acinetobacter baumannii is an emerging human pathogen that causes hospital-acquired infections. The trend in increased antimicrobial resistance limits the choice of effective antimicrobial agents. The present study reports the resistance to Acinetobacter baumannii and analyzes the associations between antibiotic use and resistance rates at a general hospital between 2010 and 2014. A total of 1,861 isolates were obtained from clinical cultures, accounting for 10.33% of all detected bacteria (1,861/18,016). The strains were mainly from respiratory samples (1,628 isolates, 87.5%) and the intensive care unit (696 isolates, 37.4%). The resistance rates of Acinetobacter baumannii to the majority of antibiotics were >50%, particularly the resistance rate to cefoperazone/sulbactam increased from 47.37 in 2011 to 89.25% in 2014. However, the rates of imipenem and cilastatin sodium decreased from 81.03 to 69.44% due to the antibiotic policy. There were Pearson significant associations between the use of three antibiotics and resistance in Acinetobacter baumannii to this drug, piperacillin/tazobactam (r=0.976, P<0.01), gentamicin (r=0.870, P<0.01) and cefoxitin (r=0.741, P<0.05). Therefore, a combination of drugs should be adopted to treat Acinetobacter baumannii infections. Microbiology laboratory support and surveillance policies are essential to control the emergence of multidrug-resistance Acinetobacter baumannii.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of drug resistance in 1,861 strains of Acinetobacter baumannii

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