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Article

Sensitization of Candida albicans to terbinafine by berberine and berberrubine

  • Authors:
    • Pikling Lam
    • Stanton Hon Lung Kok
    • Kenneth Ka Ho Lee
    • Kim Hung Lam
    • Desmond Kwok Po Hau
    • Wai Yeung Wong
    • Zhaoxiang Bian
    • Roberto Gambari
    • Chung Hin Chui
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR, P.R. China, School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China, Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, P.R. China, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, P.R. China, Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
  • Pages: 449-452
    |
    Published online on: February 23, 2016
       https://doi.org/10.3892/br.2016.608
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Abstract

Candida albicans (C. albicans) is an opportunistic fungal pathogen, particularly observed in immunocompromised patients. C. albicans accounts for 50‑70% of cases of invasive candidiasis in the majority of clinical settings. Terbinafine, an allylamine antifungal drug, has been used to treat fungal infections previously. It has fungistatic activity against C. albicans. Traditional Chinese medicines can be used as complementary medicines to conventional drugs to treat a variety of ailments and diseases. Berberine is a quaternary alkaloid isolated from the traditional Chinese herb, Coptidis Rhizoma, while berberrubine is isolated from the medicinal plant Berberis vulgaris, but is also readily derived from berberine by pyrolysis. The present study demonstrates the possible complementary use of berberine and berberrubine with terbinafine against C. albicans. The experimental findings assume that the potential application of these alkaloids together with reduced dosage of the standard drug would enhance the resulting antifungal potency.
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Copy and paste a formatted citation
Spandidos Publications style
Lam P, Kok SH, Lee KK, Lam KH, Hau DK, Wong WY, Bian Z, Gambari R and Chui CH: Sensitization of Candida albicans to terbinafine by berberine and berberrubine. Biomed Rep 4: 449-452, 2016.
APA
Lam, P., Kok, S.H., Lee, K.K., Lam, K.H., Hau, D.K., Wong, W.Y. ... Chui, C.H. (2016). Sensitization of Candida albicans to terbinafine by berberine and berberrubine. Biomedical Reports, 4, 449-452. https://doi.org/10.3892/br.2016.608
MLA
Lam, P., Kok, S. H., Lee, K. K., Lam, K. H., Hau, D. K., Wong, W. Y., Bian, Z., Gambari, R., Chui, C. H."Sensitization of Candida albicans to terbinafine by berberine and berberrubine". Biomedical Reports 4.4 (2016): 449-452.
Chicago
Lam, P., Kok, S. H., Lee, K. K., Lam, K. H., Hau, D. K., Wong, W. Y., Bian, Z., Gambari, R., Chui, C. H."Sensitization of Candida albicans to terbinafine by berberine and berberrubine". Biomedical Reports 4, no. 4 (2016): 449-452. https://doi.org/10.3892/br.2016.608
Copy and paste a formatted citation
x
Spandidos Publications style
Lam P, Kok SH, Lee KK, Lam KH, Hau DK, Wong WY, Bian Z, Gambari R and Chui CH: Sensitization of Candida albicans to terbinafine by berberine and berberrubine. Biomed Rep 4: 449-452, 2016.
APA
Lam, P., Kok, S.H., Lee, K.K., Lam, K.H., Hau, D.K., Wong, W.Y. ... Chui, C.H. (2016). Sensitization of Candida albicans to terbinafine by berberine and berberrubine. Biomedical Reports, 4, 449-452. https://doi.org/10.3892/br.2016.608
MLA
Lam, P., Kok, S. H., Lee, K. K., Lam, K. H., Hau, D. K., Wong, W. Y., Bian, Z., Gambari, R., Chui, C. H."Sensitization of Candida albicans to terbinafine by berberine and berberrubine". Biomedical Reports 4.4 (2016): 449-452.
Chicago
Lam, P., Kok, S. H., Lee, K. K., Lam, K. H., Hau, D. K., Wong, W. Y., Bian, Z., Gambari, R., Chui, C. H."Sensitization of Candida albicans to terbinafine by berberine and berberrubine". Biomedical Reports 4, no. 4 (2016): 449-452. https://doi.org/10.3892/br.2016.608
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