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Review

MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review)

  • Authors:
    • Yongmei Cao
    • Yi Lyu
    • Jiahua Tang
    • Yingchuan Li
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Department of Anesthesiology, Kunming Children's Hospital, Kunming, Yunnan 650034, P.R. China, Department of Anesthesiology, Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China
  • Pages: 523-527
    |
    Published online on: March 1, 2016
       https://doi.org/10.3892/br.2016.620
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Abstract

Acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are common and complex inflammatory lung diseases. MicroRNAs (miRNAs), a type of non-coding RNA molecule that regulate gene expression at the post-transcriptional level, have emerged as a novel class of gene regulators, which have critical roles in a wide range of human disorders and diseases, including ALI. Certain types of miRNAs are abnormally expressed in response to lung injury. miRNAs can regulate inflammation pathways by targeting specific molecules and modulate immune response in the process of lung injury and repair. The regulation of miRNA can relieve injury response and promote the recovery of ALI/ARDS. Therefore, miRNAs may serve as novel therapeutic targets in ALI/ARDS.
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1 

Zeng Z, Gong H, Li Y, Jie K, Ding C, Shao Q, Liu F, Zhan Y, Nie C, Zhu W, et al: Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury. Exp Lung Res. 39:275–282. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Parthasarathy PT, Galam L, Huynh B, Yunus A, Abuelenen T, Castillo A, Kollongod RG, Cox R Jr and Kolliputi N: MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochem Biophys Res Commun. 426:203–208. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Xie T, Liang J, Liu N, Wang Q, Li Y, Noble PW and Jiang D: MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I. J Immunol. 188:2437–2444. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Cai ZG, Zhang SM, Zhang Y, Zhou YY, Wu HB and Xu XP: MicroRNAs are dynamically regulated and play an important role in LPS-induced lung injury. Can J Physiol Pharmacol. 90:37–43. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Agarwal R, Aggarwal AN, Gupta D, Behera D and Jindal SK: Etiology and outcomes of pulmonary and extrapulmonary acute lung injury/ARDS in a respiratory ICU in North India. Chest. 130:724–729. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Oh B and Lee M: Combined delivery of HMGB-1 Box A peptide and S1PLyase siRNA in animal models of acute lung injury. J Control Release. 175:25–35. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Li J, Huang S, Wu Y, Gu C, Gao D, Feng C, Wu X and Fu X: Paracrine factors from mesenchymal stem cells: A proposed therapeutic tool for acute lung injury and acute respiratory distress syndrome. Int Wound J. 11:114–121. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, Liang Y, Ren T and Xu L: Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol. 190:4337–4348. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Johnson ER and Matthay MA: Acute lung injury: Epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 23:243–252. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Staszel T, Zapała B, Polus A, Sadakierska-Chudy A, Kieć-Wilk B, Stępień E, Wybrańska I, Chojnacka M and Dembińska-Kieć A: Role of microRNAs in endothelial cell pathophysiology. Pol Arch Med Wewn. 121:361–366. 2011.PubMed/NCBI

11 

Magenta A, Greco S, Gaetano C and Martelli F: Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci. 14:17319–17346. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Carissimi C, Fulci V and Macino G: MicroRNAs: Novel regulators of immunity. Autoimmun Rev. 8:520–524. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Ambros V: microRNAs: Tiny regulators with great potential. Cell. 107:823–826. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Oba S, Mizutani T, Suzuki E, Nishimatsu H, Takahashi M, Ogawa Y, Kimura K, Hirata Y and Fujita T: A useful method of identifying of miRNAs which can down-regulate Zeb-2. BMC Res Notes. 6:4702013. View Article : Google Scholar : PubMed/NCBI

15 

Moschos SA, Williams AE, Perry MM, Birrell MA, Belvisi MG and Lindsay MA: Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics. 8:2402007. View Article : Google Scholar : PubMed/NCBI

16 

Jamaluddin MS, Weakley SM, Zhang L, Kougias P, Lin PH, Yao Q and Chen C: miRNAs: Roles and clinical applications in vascular disease. Expert Rev Mol Diagn. 11:79–89. 2011. View Article : Google Scholar : PubMed/NCBI

17 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Guo ZL, Ren T, Xu L, Zhang L, Yin Q, Wang JC and Liang YJ: The microRNAs expression changes rapidly in mice lung tissue during lipopolysaccharide-induced acute lung injury. Chin Med J (Engl). 126:181–183. 2013.PubMed/NCBI

19 

Kim VN: MicroRNA biogenesis: Coordinated cropping and dicing. Nat Rev Mol Cell Biol. 6:376–385. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Hammond SM: RNAi, microRNAs, and human disease. Cancer Chemother Pharmacol. 58(Suppl 1): s63–s68. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Sonkoly E and Pivarcsi A: Advances in microRNAs: Implications for immunity and inflammatory diseases. J Cell Mol Med. 13:24–38. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Guo H, Ingolia NT, Weissman JS and Bartel DP: Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 466:835–840. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet. 9:102–114. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Bartel DP and Chen CZ: Micromanagers of gene expression: The potentially widespread influence of metazoan microRNAs. Nat Rev Genet. 5:396–400. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Doench JG and Sharp PA: Specificity of microRNA target selection in translational repression. Genes Dev. 18:504–511. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD and Iliopoulos D: Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 303:L199–L207. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GA, et al: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol. 179:5082–5089. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Bhargava M and Wendt CH: Biomarkers in acute lung injury. Transl Res. 159:205–217. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Angulo M, Lecuona E and Sznajder JI: Role of MicroRNAs in lung disease. Arch Bronconeumol. 48:325–330. 2012. View Article : Google Scholar : PubMed/NCBI

32 

O'Connell RM, Rao DS, Chaudhuri AA and Baltimore D: Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 10:111–122. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Xiao C and Rajewsky K: MicroRNA control in the immune system: Basic principles. Cell. 136:26–36. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Vergadi E, Vaporidi K, Theodorakis EE, Doxaki C, Lagoudaki E, Ieronymaki E, Alexaki VI, Helms M, Kondili E, Soennichsen B, et al: Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice. J Immunol. 192:394–406. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, et al: MICU Registry: MicroRNA-181b regulates NF-κB-mediated vascular inflammation. J Clin Invest. 122:1973–1990. 2012.PubMed/NCBI

37 

Zhou T, Garcia JG and Zhang W: Integrating microRNAs into a system biology approach to acute lung injury. Transl Res. 157:180–190. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Taganov KD, Boldin MP and Baltimore D: MicroRNAs and immunity: Tiny players in a big field. Immunity. 26:133–137. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Cross LJ and Matthay MA: Biomarkers in acute lung injury: Insights into the pathogenesis of acute lung injury. Crit Care Clin. 27:355–377. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Roy S and Sen CK: miRNA in innate immune responses: Novel players in wound inflammation. Physiol Genomics. 43:557–565. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao Y, Lyu Y, Tang J and Li Y: MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review). Biomed Rep 4: 523-527, 2016.
APA
Cao, Y., Lyu, Y., Tang, J., & Li, Y. (2016). MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review). Biomedical Reports, 4, 523-527. https://doi.org/10.3892/br.2016.620
MLA
Cao, Y., Lyu, Y., Tang, J., Li, Y."MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review)". Biomedical Reports 4.5 (2016): 523-527.
Chicago
Cao, Y., Lyu, Y., Tang, J., Li, Y."MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review)". Biomedical Reports 4, no. 5 (2016): 523-527. https://doi.org/10.3892/br.2016.620
Copy and paste a formatted citation
x
Spandidos Publications style
Cao Y, Lyu Y, Tang J and Li Y: MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review). Biomed Rep 4: 523-527, 2016.
APA
Cao, Y., Lyu, Y., Tang, J., & Li, Y. (2016). MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review). Biomedical Reports, 4, 523-527. https://doi.org/10.3892/br.2016.620
MLA
Cao, Y., Lyu, Y., Tang, J., Li, Y."MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review)". Biomedical Reports 4.5 (2016): 523-527.
Chicago
Cao, Y., Lyu, Y., Tang, J., Li, Y."MicroRNAs: Novel regulatory molecules in acute lung injury/acute respiratory distress syndrome (Review)". Biomedical Reports 4, no. 5 (2016): 523-527. https://doi.org/10.3892/br.2016.620
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