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Article

Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy

  • Authors:
    • Bo Feng
    • Wei Wu
    • Hua Wang
    • Junchen Wang
    • Dongya Huang
    • Ling Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Department of Pathology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Department of Traditional Chinese Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China
  • Pages: 589-594
    |
    Published online on: March 22, 2016
       https://doi.org/10.3892/br.2016.637
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Abstract

The side-to-side difference in bone mineral content and soft tissue composition of extremities and their associations have been observed in patients with stroke and the results are inconsistent. The aim of the present study was to investigate the interaction between bone mineral content (BMC), lean mass (LM) and fat mass (FM) in the paretic extremities in patients following stroke and to determine the effectiveness of electrical muscle stimulation (EMS) following sciatic neurectomy (SN) in rats. BMC, LM and FM were measured by dual‑energy X‑ray absorptiometry in 61 hemiplegic patients following stroke. In the rat model study, groups of 10 Sprague‑Dawley rats were divided into EMS and non‑EMS subgroups. Myostatin expression and tetracycline interlabel width were measured. There were significant decreases in BMC, LM and FM in paretic limbs compared to non‑paretic limbs. Compared to non‑EMS, downregulated myostatin mRNA, and upregulated mechano growth factor (MGF) and insulin‑like growth factor 1 (IGF‑1) mRNA expression levels were observed in the EMS subgroup (P<0.05). In conclusion, muscle may have an important role in maintaining BMC. EMS‑induced muscle contraction effectively downregulated myostatin mRNA, upregulated MGF and IGF‑1 mRNA expression in muscle fiber, and mitigated amyotrophy and cortical bone loss from SN.
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Copy and paste a formatted citation
Spandidos Publications style
Feng B, Wu W, Wang H, Wang J, Huang D and Cheng L: Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy. Biomed Rep 4: 589-594, 2016.
APA
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., & Cheng, L. (2016). Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy. Biomedical Reports, 4, 589-594. https://doi.org/10.3892/br.2016.637
MLA
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., Cheng, L."Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy". Biomedical Reports 4.5 (2016): 589-594.
Chicago
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., Cheng, L."Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy". Biomedical Reports 4, no. 5 (2016): 589-594. https://doi.org/10.3892/br.2016.637
Copy and paste a formatted citation
x
Spandidos Publications style
Feng B, Wu W, Wang H, Wang J, Huang D and Cheng L: Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy. Biomed Rep 4: 589-594, 2016.
APA
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., & Cheng, L. (2016). Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy. Biomedical Reports, 4, 589-594. https://doi.org/10.3892/br.2016.637
MLA
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., Cheng, L."Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy". Biomedical Reports 4.5 (2016): 589-594.
Chicago
Feng, B., Wu, W., Wang, H., Wang, J., Huang, D., Cheng, L."Interaction between muscle and bone, and improving the effects of electrical muscle stimulation on amyotrophy and bone loss in a denervation rat model via sciatic neurectomy". Biomedical Reports 4, no. 5 (2016): 589-594. https://doi.org/10.3892/br.2016.637
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