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Article

Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy

  • Authors:
    • Masahiko Sumitani
    • Toru Ogata
    • Akina Natori
    • Jun Hozumi
    • Nobutake Shimojo
    • Kumiko Kida
    • Hideko Yamauchi
    • Teruo Yamauchi
  • View Affiliations / Copyright

    Affiliations: Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113‑0033, Japan, Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Saitama 359‑8555, Japan, The Oncology and Breast Centers, St. Luke's International Hospital, Tokyo 104‑8560, Japan, Department of Critical Care Medicine, Tsukuba University Hospital, Tsukuba, Ibaraki 305‑8576, Japan
  • Pages: 758-760
    |
    Published online on: April 8, 2016
       https://doi.org/10.3892/br.2016.648
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Abstract

The phosphorylated form of the high-mole­cular‑weight neurofilament heavy subunit (pNF-H) is a major structural protein in axons. The pNF-H level is elevated in the serum of certain patients with central nervous disorders, including chemotherapy‑induced cognitive impairment. The present study was conducted to elucidate the potential role of pNF‑H as a marker of chemotherapy‑induced peripheral neuropathy (CIPN). A total of 71 patients with early breast cancer in various stages of treatment (following 1, 3 or 7 cycles of chemotherapy, or a previous history of breast cancer chemotherapy) were assessed with a self-administered PainDETECT questionnaire [pain location, pain intensity on an 11‑point numeric rating scale (NRS), and various pain qualities] and a single serum pNF-H measurement. Patients were divided into two groups based on the presence or absence of bilateral symmetric pain in the distal portions of the extremities [CIPN(+) or CIPN(-)]. The χ2 and Mann-Whitney tests were used for statistical analyses. Among the participants, only 8 patients complained of CIPN. Their pain intensity was 3.5±1.9 (mean ± standard deviation) compared with 1.5±1.8 in the CIPN(-) group (P<0.01). The NRS of numbness in the CIPN(+) group was significantly higher (2.4±1.4) than that of the CIPN(-) group (1.0±1.0). Increased pNF‑H levels were observed in 37.5% of the CIPN(+) patients and in 23.8% of CIPN(-) patients (P=0.40). In conclusion, CIPN is observed in the most distal portions of the peripheral nerves that are composed of dendrites but not axons. Although serum pNF‑H is a biomarker of axonal damage, it is not useful as a marker of CIPN.
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Copy and paste a formatted citation
Spandidos Publications style
Sumitani M, Ogata T, Natori A, Hozumi J, Shimojo N, Kida K, Yamauchi H and Yamauchi T: Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy. Biomed Rep 4: 758-760, 2016.
APA
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K. ... Yamauchi, T. (2016). Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy. Biomedical Reports, 4, 758-760. https://doi.org/10.3892/br.2016.648
MLA
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K., Yamauchi, H., Yamauchi, T."Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy". Biomedical Reports 4.6 (2016): 758-760.
Chicago
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K., Yamauchi, H., Yamauchi, T."Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy". Biomedical Reports 4, no. 6 (2016): 758-760. https://doi.org/10.3892/br.2016.648
Copy and paste a formatted citation
x
Spandidos Publications style
Sumitani M, Ogata T, Natori A, Hozumi J, Shimojo N, Kida K, Yamauchi H and Yamauchi T: Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy. Biomed Rep 4: 758-760, 2016.
APA
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K. ... Yamauchi, T. (2016). Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy. Biomedical Reports, 4, 758-760. https://doi.org/10.3892/br.2016.648
MLA
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K., Yamauchi, H., Yamauchi, T."Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy". Biomedical Reports 4.6 (2016): 758-760.
Chicago
Sumitani, M., Ogata, T., Natori, A., Hozumi, J., Shimojo, N., Kida, K., Yamauchi, H., Yamauchi, T."Poor efficacy of the phosphorylated high-molecular-weight neurofilament heavy subunit serum level, a biomarker of axonal damage, as a marker of chemotherapy-induced peripheral neuropathy". Biomedical Reports 4, no. 6 (2016): 758-760. https://doi.org/10.3892/br.2016.648
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