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Article

Rhythmic expression of DEC2 protein in vitro and in vivo

  • Authors:
    • Fuyuki Sato
    • Yasuteru Muragaki
    • Takeshi Kawamoto
    • Katsumi Fujimoto
    • Yukio Kato
    • Yanping Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA, Department of Pathology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan, Department of Dental and Medical Biochemistry, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
  • Pages: 704-710
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    Published online on: April 14, 2016
       https://doi.org/10.3892/br.2016.656
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Abstract

Basic helix-loop-helix (bHLH) transcription factor DEC2 (bHLHE41/Sharp1) is one of the clock genes that show a circadian rhythm in various tissues. DEC2 regulates differentiation, sleep length, tumor cell invasion and apoptosis. Although studies have been conducted on the rhythmic expression of DEC2 mRNA in various tissues, the precise molecular mechanism of DEC2 expression is poorly understood. In the present study, we examined whether DEC2 protein had a rhythmic expression. Western blot analysis for DEC2 protein revealed a rhythmic expression in mouse liver, lung and muscle and in MCF-7 and U2OS cells. In addition, AMP-activated protein kinase (AMPK) activity (phosphorylation of AMPK) in mouse embryonic fibroblasts (MEFs) exhibited a rhythmic expression under the condition of medium change or glucose‑depleted medium. However, the rhythmic expression of DEC2 in MEF gradually decreased in time under these conditions. The medium change affected the levels of DEC2 protein and phosphorylation of AMPK. In addition, the levels of DEC2 protein showed a rhythmic expression in vivo and in MCF-7 and U2OS cells. The results showed that the phosphorylation of AMPK immunoreactivity was strongly detected in the liver and lung of DEC2 knockout mice compared with that of wild-type mice. These results may provide new insights into rhythmic expression and the regulation between DEC2 protein and AMPK activity.
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View References

1 

Merrow M, Spoelstra K and Roenneberg T: The circadian cycle: Daily rhythms from behaviour to genes. EMBO Rep. 6:930–935. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS and Weitz CJ: Role of the CLOCK protein in the mammalian circadian mechanism. Science. 280:1564–1569. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y and Honma K: Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 419:841–844. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Turek FW: From circadian rhythms to clock genes in depression. Int Clin Psychopharmacol. 22(Suppl 2): S1–S8. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, et al: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 466:627–631. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, et al: Obesity and metabolic syndrome in circadian Clock mutant mice. Science. 308:1043–1045. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Parent MÉ, El-Zein M, Rousseau MC, Pintos J and Siemiatycki J: Night work and the risk of cancer among men. Am J Epidemiol. 176:751–759. 2012. View Article : Google Scholar : PubMed/NCBI

8 

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner MJ, Nishino S and Fu YH: The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 325:866–870. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Rosen G and Brand SR: Sleep in children with cancer: Case review of 70 children evaluated in a comprehensive pediatric sleep center. Support Care Cancer. 19:985–994. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y and Kijima H: Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. Int J Mol Med. 27:491–495. 2011.PubMed/NCBI

11 

Wu Y, Sato F, Yamada T, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Hakamada K, et al: The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer. Int J Oncol. 41:1337–1346. 2012.PubMed/NCBI

12 

Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y, Turek FW and Bass J: High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 6:414–421. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Kohsaka A, Das P, Hashimoto I, Nakao T, Deguchi Y, Gouraud SS, Waki H, Muragaki Y and Maeda M: The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS One. 9:e1128112014. View Article : Google Scholar : PubMed/NCBI

14 

Sun H, Lu B, Li RQ, Flavell RA and Taneja R: Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat Immunol. 2:1040–1047. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Papagerakis S, Zheng L, Schnell S, Sartor MA, Somers E, Marder W, McAlpin B, Kim D, McHugh J and Papagerakis P: The circadian clock in oral health and diseases. J Dent Res. 93:27–35. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Baier PC, Brzózka MM, Shahmoradi A, Reinecke L, Kroos C, Wichert SP, Oster H, Wehr MC, Taneja R, Hirrlinger J, et al: Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS One. 9:e1103102014. View Article : Google Scholar : PubMed/NCBI

17 

Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K and Kato Y: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 271:4409–4419. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, Iwata T, Fujimoto K, Furukawa M, Miyazaki K, et al: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 313:117–124. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Noshiro M, Furukawa M, Honma S, Kawamoto T, Hamada T, Honma K and Kato Y: Tissue-specific disruption of rhythmic expression of Dec1 and Dec2 in clock mutant mice. J Biol Rhythms. 20:404–418. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H and Kato Y: Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem. 277:47014–47021. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Imaizumi T, Imanaka T, Kondo J, Koyanagi S, Noshiro M, Yoshida H, et al: Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression. Genes Cells. 13:131–144. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Iwata T, Kawamoto T, Sasabe E, Miyazaki K, Fujimoto K, Noshiro M, Kurihara H and Kato Y: Effects of overexpression of basic helix-loop-helix transcription factor Dec1 on osteogenic and adipogenic differentiation of mesenchymal stem cells. Eur J Cell Biol. 85:423–431. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Sato F, Kawamura H, Wu Y, Sato H, Jin D, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, et al: The basic helix-loop-helix transcription factor DEC2 inhibits TGF-β-induced tumor progression in human pancreatic cancer BxPC-3 cells. Int J Mol Med. 30:495–501. 2012.PubMed/NCBI

24 

Turley H, Wykoff CC, Troup S, Watson PH, Gatter KC and Harris AL: The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours. J Pathol. 203:808–813. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshiyama Y, Sato F, Fujimoto K, et al: Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells. Mol Pharmacol. 81:739–747. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Sato F, Sato H, Jin D, Bhawal UK, Wu Y, Noshiro M, Kawamoto T, Fujimoto K, Seino H, Morohashi S, et al: Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver. Biochem Biophys Res Commun. 419:441–446. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Sato F and Muragaki Y: Circadian expression of DEC1, SMAD3 and SNAIL in human mesenchymal stem cells. J Stem Cells Res, Rev & Rep. 1:1–3. 2014.

28 

Oishi K, Koyanagi S and Ohkura N: Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice. Exp Gerontol. 46:994–999. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, et al: DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 28:4080–4092. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Hardie DG: AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 25:1895–1908. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Cantó C and Auwerx J: AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci. 67:3407–3423. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Mihaylova MM and Shaw RJ: The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 13:1016–1023. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Yun H, Kim HS, Lee S, Kang I, Kim SS, Choe W and Ha J: AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation. Carcinogenesis. 30:529–537. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Um JH, Pendergast JS, Springer DA, Foretz M, Viollet B, Brown A, Kim MK, Yamazaki S and Chung JH: AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. PLoS One. 6:e184502011. View Article : Google Scholar : PubMed/NCBI

35 

Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, et al: AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 326:437–440. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Sato F, Muragaki Y and Zhang Y: DEC1 negatively regulates AMPK activity via LKB1. Biochem Biophys Res Commun. 467:711–716. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Clegg HV, Itahana Y, Itahana K, Ramalingam S and Zhang Y: Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction. PLoS One. 7:e382122012. View Article : Google Scholar : PubMed/NCBI

38 

Noshiro M, Kawamoto T, Furukawa M, Fujimoto K, Yoshida Y, Sasabe E, Tsutsumi S, Hamada T, Honma S, Honma K, et al: Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP. Genes Cells. 9:317–329. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Wu T, Ni Y, Zhuge F, Sun L, Xu B, Kato H and Fu Z: Significant dissociation of expression patterns of the basic helix-loop-helix transcription factors Dec1 and Dec2 in rat kidney. J Exp Biol. 214:1257–1263. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Choi SM, Cho HJ, Cho H, Kim KH, Kim JB and Park H: Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism. Nucleic Acids Res. 36:6372–6385. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Azmi S, Ozog A and Taneja R: Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J Biol Chem. 279:52643–52652. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Tanoue S, Fujimoto K, Myung J, Hatanaka F, Kato Y and Takumi T: DEC2-E4BP4 heterodimer represses the transcriptional enhancer activity of the EE element in the Per2 promoter. Front Neurol. 6:1662015.doi: 10.3389/fneur.2015.00166. View Article : Google Scholar : PubMed/NCBI

43 

Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, Yoshiga K, Poellinger L, Hiyama E and Nishiyama M: Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. Oncogene. 27:4200–4209. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T and Fukada Y: Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J Biol Chem. 277:44244–44251. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, et al: Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes Cells. 15:315–325. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Hu T, He N, Yang Y, Yin C, Sang N and Yang Q: DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas. J Exp Clin Cancer Res. 34:222015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y and Zhang Y: Rhythmic expression of DEC2 protein in vitro and in vivo. Biomed Rep 4: 704-710, 2016.
APA
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., & Zhang, Y. (2016). Rhythmic expression of DEC2 protein in vitro and in vivo. Biomedical Reports, 4, 704-710. https://doi.org/10.3892/br.2016.656
MLA
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., Zhang, Y."Rhythmic expression of DEC2 protein in vitro and in vivo". Biomedical Reports 4.6 (2016): 704-710.
Chicago
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., Zhang, Y."Rhythmic expression of DEC2 protein in vitro and in vivo". Biomedical Reports 4, no. 6 (2016): 704-710. https://doi.org/10.3892/br.2016.656
Copy and paste a formatted citation
x
Spandidos Publications style
Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y and Zhang Y: Rhythmic expression of DEC2 protein in vitro and in vivo. Biomed Rep 4: 704-710, 2016.
APA
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., & Zhang, Y. (2016). Rhythmic expression of DEC2 protein in vitro and in vivo. Biomedical Reports, 4, 704-710. https://doi.org/10.3892/br.2016.656
MLA
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., Zhang, Y."Rhythmic expression of DEC2 protein in vitro and in vivo". Biomedical Reports 4.6 (2016): 704-710.
Chicago
Sato, F., Muragaki, Y., Kawamoto, T., Fujimoto, K., Kato, Y., Zhang, Y."Rhythmic expression of DEC2 protein in vitro and in vivo". Biomedical Reports 4, no. 6 (2016): 704-710. https://doi.org/10.3892/br.2016.656
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