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Article

Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage

  • Authors:
    • Jing Chen
    • Yan‑Hui Chen
    • Hong‑Yan Lv
    • Li‑Ting Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
  • Pages: 136-140
    |
    Published online on: May 10, 2016
       https://doi.org/10.3892/br.2016.673
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Abstract

The aim of the present study was to investigate the effect of hyperbaric oxygen (HBO) on lipid peroxidation and visual development in a neonatal rat model of hypoxic‑ischemic brain damage (HIBD). The rat models of HIBD were established by delayed uterus dissection and were divided randomly into two groups (10 rats each): HIBD and HBO‑treated HIBD (HIBD+HBO) group. Another 20 rats that underwent sham-surgery were also divided randomly into the HBO‑treated and control groups. The rats that underwent HBO treatment received HBO (0.02 MPa, 1 h/day) 24 h after the surgery and this continued for 14 days. When rats were 4 weeks old, their flash visual evoked potentials (F‑VEPs) were monitored and the ultrastructures of the hippocampus were observed under transmission electron microscope. The levels of superoxide dismutase (SOD) and malonyldialdehyde (MDA) in the brain tissue homogenate were detected by xanthine oxidase and the thiobarbituric acid colorimetric method. Compared with the control group, the ultrastructures of the pyramidal neurons in the hippocampal CA3 area were distorted, the latencies of F‑VEPs were prolonged (P<0.01) and the SOD activities were lower while the MDA levels were higher (P<0.01) in the HIBD group. No significant differences in ultrastructure, the latency of F-VEPs or SOD/MDA levels were identified between the HBO‑treated HIBD group and the normal control group (P>0.05). HBO enhances antioxidant capacity and reduces the ultrastructural damage induced by hypoxic‑ischemia, which may improve synaptic reconstruction and alleviate immature brain damage to promote the habilitation of brain function.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Chen YH, Lv HY and Chen LT: Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage. Biomed Rep 5: 136-140, 2016.
APA
Chen, J., Chen, Y., Lv, H., & Chen, L. (2016). Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage. Biomedical Reports, 5, 136-140. https://doi.org/10.3892/br.2016.673
MLA
Chen, J., Chen, Y., Lv, H., Chen, L."Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage". Biomedical Reports 5.1 (2016): 136-140.
Chicago
Chen, J., Chen, Y., Lv, H., Chen, L."Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage". Biomedical Reports 5, no. 1 (2016): 136-140. https://doi.org/10.3892/br.2016.673
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Chen YH, Lv HY and Chen LT: Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage. Biomed Rep 5: 136-140, 2016.
APA
Chen, J., Chen, Y., Lv, H., & Chen, L. (2016). Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage. Biomedical Reports, 5, 136-140. https://doi.org/10.3892/br.2016.673
MLA
Chen, J., Chen, Y., Lv, H., Chen, L."Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage". Biomedical Reports 5.1 (2016): 136-140.
Chicago
Chen, J., Chen, Y., Lv, H., Chen, L."Effect of hyperbaric oxygen on lipid peroxidation and visual development in neonatal rats with hypoxia-ischemia brain damage". Biomedical Reports 5, no. 1 (2016): 136-140. https://doi.org/10.3892/br.2016.673
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