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Article

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

  • Authors:
    • Ning Tang
    • Yaping Zhang
    • Zeyu Liu
    • Tao Fu
    • Qinghong Liang
    • Xuemei Ai
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Worker's Hospital of China Electronics Technology Group Corporation 54, Shijiazhuang, Hebei 050081, P.R. China
  • Pages: 107-112
    |
    Published online on: May 18, 2016
       https://doi.org/10.3892/br.2016.681
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Abstract

The aim of the present study was to investigate the correlation between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. A total of 30 infants with cholestasis and 20 healthy infants were included in the study. Biochemical assays based on the initial rate method and colorimetric assays were conducted to determine the levels of liver function markers in the serum [such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), γ‑glutamyl transferase (γ‑GT), cholinesterase (CHE) and total bile acids (TBA)] and four serum biomarkers of liver fibrosis were measured using radioimmunoassays [hyaluronic acid (HA), procollagen type III (PCIII), laminin (LN) and collagen type IV (cIV)]. The serum levels of ALT, AST, TBIL, DBIL, IBIL, γ‑GT and TBA in the infants with cholestasis were significantly higher compared to the healthy infants (P<0.01); the serum levels of CHE in the infants with cholestasis were significantly lower compared to the healthy infants (P<0.01). The serum levels of HA, PCIII, and cIV in the infants with cholestasis were significantly higher compared to the healthy infants (P<0.01). Correlation analyses between liver function and the four biomarkers of liver fibrosis showed that HA was positively correlated with AST and γ‑GT (P<0.05) and negatively correlated with ALT, CHE and TBA (P<0.05). cIV was positively correlated with γ‑GT (P<0.05) and negatively correlated with CHE (P<0.05). In conclusion, statistically significant differences were identified for the liver function markers (ALT, AST, TBIL, DBIL, IBIL, γ‑GT and TBA) and the biomarkers HA, PCIII and cIV of liver fibrosis between infants with cholestasis and healthy infants. Thus, the serum levels of HA, cIV, γ‑GT and CHE are sensitive markers for cholestatic liver fibrosis in infants.
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Copy and paste a formatted citation
Spandidos Publications style
Tang N, Zhang Y, Liu Z, Fu T, Liang Q and Ai X: Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomed Rep 5: 107-112, 2016.
APA
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., & Ai, X. (2016). Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomedical Reports, 5, 107-112. https://doi.org/10.3892/br.2016.681
MLA
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., Ai, X."Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis". Biomedical Reports 5.1 (2016): 107-112.
Chicago
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., Ai, X."Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis". Biomedical Reports 5, no. 1 (2016): 107-112. https://doi.org/10.3892/br.2016.681
Copy and paste a formatted citation
x
Spandidos Publications style
Tang N, Zhang Y, Liu Z, Fu T, Liang Q and Ai X: Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomed Rep 5: 107-112, 2016.
APA
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., & Ai, X. (2016). Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomedical Reports, 5, 107-112. https://doi.org/10.3892/br.2016.681
MLA
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., Ai, X."Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis". Biomedical Reports 5.1 (2016): 107-112.
Chicago
Tang, N., Zhang, Y., Liu, Z., Fu, T., Liang, Q., Ai, X."Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis". Biomedical Reports 5, no. 1 (2016): 107-112. https://doi.org/10.3892/br.2016.681
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