Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
July-2016 Volume 5 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 5 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk

  • Authors:
    • Taiming Li
    • Chengdi Wang
    • Zhenju Ren
    • Yi Ji
    • Chang Xu
    • Bing Xiao
    • Min Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Respiratory Medicine, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Urinary Surgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 93-100
    |
    Published online on: May 19, 2016
       https://doi.org/10.3892/br.2016.683
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The cytotoxic T-lymphocyte antigen 4 (CTLA-4) polymorphic loci -318 cytosine/thymine (-318C/T) has been previously implicated in malignant tumor susceptibility. However, there were no precise conclusions about the correlation, the results from published studies were inconclusive. The aim of the current meta‑analysis was to investigate the associations between CTLA-4 ‑318C/T polymorphisms and risk of malignant tumors in Asian population. We conducted a search in PubMed, Embase, the Chinese Journals Full‑Text Database, Chinese Biomedical Database, and the Wanfang database. All studies were published up to September 30, 2015. Two reviewers analysed the data independently. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. In total, 20 case‑controlled studies with 3,539 cases and 4,690 controls were included in the final meta‑analysis. The overall estimation demonstrated a significant association between CTLA‑4 ‑318C/T polymorphism and malignant tumor risk in the Asian populations (TT+TC vs. CC: OR, 1.28; 95% CI, 1.07‑1.53. TT vs. TC+CC: OR, 1.43; 95% CI, 1.03‑1.99; TT vs. CC: OR, 1.51; 95% CI, 1.09‑2.10. TC vs. CC: OR, 1.26; 95% CI, 1.06‑1.50. T vs. C: OR, 1.25, 95% CI, 1.05‑1.47). In the subgroup analysis by countries, we found that the dominant model (TT+TC vs. CC) revealed an increased risk of developing malignant tumors in the Chinese study population (OR, 1.41; 95% CI, 1.13‑1.76), but no association was demonstrated in the other countries. The current meta‑analysis suggests that CTLA‑4 ‑318C/T polymorphism is significantly associated with the risk of malignance tumors in Asian populations, especially in those from China. Further studies for additional Asian countries are required to further evaluate the association.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Bredberg A: Cancer: More of polygenic disease and less of multiple mutations? A quantitative viewpoint. Cancer. 117:440–445. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Wong YK, Chang KW, Cheng CY and Liu CJ: Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma. J Oral Pathol Med. 35:51–54. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Ramakrishnan R and Gabrilovich DI: Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer. Cancer Immunol Immunother. 62:405–410. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Zhang Y, Zhang J, Deng Y, Tian C, Li X, Huang J and Fan H: Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and cancer risk: A meta-analysis. Cancer. 117:4312–4324. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Ghaderi A: CTLA4 gene variants in autoimmunity and cancer: A comparative review. Iran J Immunol. 8:127–149. 2011.PubMed/NCBI

6 

Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, et al: Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res. 68:7025–7034. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Cheng TY, Lin JT, Chen LT, Shun CT, Wang HP, Lin MT, Wang TE, Cheng AL and Wu MS: Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma. J Clin Oncol. 24:3483–3489. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Erfani N, Razmkhah M, Talei AR, Pezeshki AM, Doroudchi M, Monabati A and Ghaderi A: Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer. Cancer Genet Cytogenet. 165:114–120. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wang L and Li D, Fu Z, Li H, Jiang W and Li D: Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. BMC Cancer. 7:1732007. View Article : Google Scholar : PubMed/NCBI

10 

Su TH, Chang TY, Lee YJ, Chen CK, Liu HF, Chu CC, Lin M, Wang PT, Huang WC, Chen TC, et al: CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women. Carcinogenesis. 28:1237–1240. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Hadinia A, Hossieni SV, Erfani N, Saberi-Firozi M, Fattahi MJ and Ghaderi A: CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers. J Gastroenterol Hepatol. 22:2283–2287. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Li R, Xia B, Xiao H, Jiang Y and Zhou F: Association between CTLA-4 gene promoter region polymorphisms at positions −1661 and −318 and gastric cancer. Clin J Gastroenterol. 14:332–336. 2009.

13 

Khaghanzadeh N, Erfani N, Ghayumi MA and Ghaderi A: CTLA4 gene variations and haplotypes in patients with lung cancer. Cancer Genet Cytogenet. 196:171–174. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Rahimifar S, Erfani N, Sarraf Z and Ghaderi A: ctla-4 gene variations may influence cervical cancer susceptibility. Gynecol Oncol. 119:136–139. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Liu Y, He Z, Feng D, Shi G, Gao R, Wu X, Song W and Yuan W: Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to osteosarcoma. DNA Cell Biol. 30:1051–1055. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Jiang L, Luo RY, Zhang W, Wang LR, Wang F and Cheng YX: Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 28:313–317. 2011.(In Chinese). PubMed/NCBI

17 

Yang S, Wang C, Zhou Y, Sun G, Zhu D and Gao S: Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to Ewing's sarcoma. Genet Test Mol Biomarkers. 16:1236–1240. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Gokhale P, Kerkar S, Tongaonkar H, Salvi V and Mania-Pramanik J: CTLA-4 gene polymorphism at position +49 A>G in exon 1: A risk factor for cervical cancer in Indian women. Cancer Genet. 206:154–161. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Feng D, Yang X, Li S, Liu T, Wu Z, Song Y, Wang J, Gao W, Huang Q, Huang W, et al: Cytotoxic T-lymphocyte antigen-4 genetic variants and risk of Ewing's sarcoma. Genet Test Mol Biomarkers. 17:458–463. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Bharti V, Mohanti BK and Das SN: Functional genetic variants of CTLA-4 and risk of tobacco-related oral carcinoma in high-risk North Indian population. Hum Immunol. 74:348–352. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Liu J, Liu J, Song B, Wang T, Liu Y, Hao J and Yu J: Genetic variations in CTLA-4, TNF-α, and LTA and susceptibility to T-cell lymphoma in a Chinese population. Cancer Epidemiol. 37:930–934. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Jaiswal PK, Singh V and Mittal RD: Cytotoxic T lymphocyte antigen 4 (CTLA4) gene polymorphism with bladder cancer risk in North Indian population. Mol Biol Rep. 41:799–807. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Xiong YH, He L and Fei J: Genetic variations in cytotoxic T-lymphocyte antigen-4 and susceptibility to cervical cancer. Int Immunopharmacol. 18:71–76. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Hui L, Lei Z, Peng Z, Ruobing S and Fenghua Z: Polymorphism analysis of CTLA-4 in childhood acute lymphoblastic leukemia. Pak J Pharm Sci. 27(Suppl 4): 1005–1013. 2014.PubMed/NCBI

25 

Cheng S, Li J, Liu W, Liu C, Su L, Liu X, Guo L, Ma Y, Song B and Liu J: LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: A case-control study. BMC Cancer. 15:4802015. View Article : Google Scholar : PubMed/NCBI

26 

Wang JJ, Wang ZB and Huang WF: The correlation of cytotoxic T lymphocyte antigen 4 polymorphisms with occurrence of cervical cancer. Pract J Clin Med. 12:77–80. 2015.

27 

Jackson D, White IR and Riley RD: Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 31:3805–3820. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Leach DR, Krummel MF and Allison JP: Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271:1734–1736. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Xu HB, Yang H, Liu T and Chen H: Association of CTLA4 gene polymorphism (rs5742909) with cervical cancer: A meta-analysis. Tumour Biol. 35:1605–1608. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li T, Wang C, Ren Z, Ji Y, Xu C, Xiao B and Liu M: Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk. Biomed Rep 5: 93-100, 2016.
APA
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., & Liu, M. (2016). Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk. Biomedical Reports, 5, 93-100. https://doi.org/10.3892/br.2016.683
MLA
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., Liu, M."Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk". Biomedical Reports 5.1 (2016): 93-100.
Chicago
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., Liu, M."Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk". Biomedical Reports 5, no. 1 (2016): 93-100. https://doi.org/10.3892/br.2016.683
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Wang C, Ren Z, Ji Y, Xu C, Xiao B and Liu M: Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk. Biomed Rep 5: 93-100, 2016.
APA
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., & Liu, M. (2016). Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk. Biomedical Reports, 5, 93-100. https://doi.org/10.3892/br.2016.683
MLA
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., Liu, M."Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk". Biomedical Reports 5.1 (2016): 93-100.
Chicago
Li, T., Wang, C., Ren, Z., Ji, Y., Xu, C., Xiao, B., Liu, M."Association between the cytotoxic T-lymphocyte antigen 4 -318C/T polymorphism and malignant tumor risk". Biomedical Reports 5, no. 1 (2016): 93-100. https://doi.org/10.3892/br.2016.683
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team