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Article

Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model

  • Authors:
    • Yuki Yamasaki
    • Takashi Fujimura
    • Katsunobu Oyama
    • Yuki Higashi
    • Atsushi Hirose
    • Tomoya Tsukada
    • Koichi Okamoto
    • Jun Kinoshita
    • Keishi Nakamura
    • Tomoharu Miyashita
    • Hidehiro Tajima
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Sachio Fushida
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa 920‑8641, Japan
  • Pages: 118-124
    |
    Published online on: May 23, 2016
       https://doi.org/10.3892/br.2016.689
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Abstract

Proton pump inhibitors (PPIs) are frequently prescribed to patients with gastroesophageal reflux disease; however, the number of bone fractures reportedly increased in these patients. Although PPIs have been shown to inhibit the bone resorption by osteoclasts, the effect of PPIs on skeletal metabolism remains controversial. The aim of the present study was to determine the effect of the PPI rabeprazole on skeletal metabolism using gastrectomized rats. Male Wistar rats were divided into four groups: i) Sham‑surgery (n=15); ii) total gastrectomy (TG) control (n=20); iii) TG plus rabeprazole (n=20); and iv) TG plus the bisphosphonate minodronic acid (n=20). Twenty‑two weeks after TG, the rats were sacrificed, and bone mineral density (BMD), bone strength and markers for bone metabolism were measured. Compared with the control group (50.0±8.1%), the TG‑induced decrease in BMD was significantly ameliorated in the rabeprazole group (56.5±7.5%) and the minodronic acid group (59.0±6.0%). However, rabeprazole did not improve bone strength. In conclusion, rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease.
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1 

Johnell O and Kanis JA: An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 17:1726–1733. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Cumming RG, Nevitt MC and Cummings SR: Epidemiology of hip fractures. Epidemiol Rev. 19:244–257. 1997. View Article : Google Scholar : PubMed/NCBI

3 

Leibson CL, Tosteson AN, Gabriel SE, Ransom JE and Melton LJ III: Mortality, disability, and nursing home use for persons with and without hip fracture: A population-based study. J Am Geriatr Soc. 50:1644–1650. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Hofbauer LC, Hamann C and Ebeling PR: Approach to the patient with secondary osteoporosis. Eur J Endocrinol. 162:1009–1020. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Bernstein CN, Leslie WD and Leboff MS: AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 124:795–841. 2003. View Article : Google Scholar : PubMed/NCBI

6 

van Staa TP, Geusens P, Bijlsma JW, Leufkens HG and Cooper C: Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum. 54:3104–3112. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Melton LJ III, Kyle RA, Achenbach SJ, Oberg AL and Rajkumar SV: Fracture risk with multiple myeloma: A population-based study. J Bone Miner Res. 20:487–493. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Sarasin C: Osteomalacie und hypochrome anaemie nach magenresektion. Gastroenterologia. 66:182–197. 1941. View Article : Google Scholar

9 

Klinge B, Lehto-Axtelius D, Akerman M and Håkanson R: Structure of calvaria after gastrectomy. An experimental study in the rat. Scand J Gastroenterol. 30:952–957. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Lehto-Axtelius D, Surve VV, Johnell O and Håkanson R: Effects of calcium deficiency and calcium supplementation on gastrectomy-induced osteopenia in the young male rat. Scand J Gastroenterol. 37:299–306. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Axelson J, Persson P, Gagnemo-Persson R and Håkanson R: Importance of the stomach in maintaining calcium homoeostasis in the rat. Gut. 32:1298–1302. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Persson P, Gagnemo-Persson R, Chen D, Axelson J, Nylander AG, Johnell O and Häkanson R: Gastrectomy causes bone loss in the rat: Is lack of gastric acid responsible? Scand J Gastroenterol. 28:301–306. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Mühlbauer RC, Schenk RK, Chen D, Lehto-Axtelius D and Hâkanson R: Morphometric analysis of gastrectomy-evoked osteopenia. Calcif Tissue Int. 62:323–326. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Targownik LE, Lix LM, Metge CJ, Prior HJ, Leung S and Leslie WD: Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 179:319–326. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Chonan O, Takahashi R, Yasui H and Watanuki M: Effect of L-lactic acid on calcium absorption in rats fed omeprazole. J Nutr Sci Vitaminol (Tokyo). 44:473–481. 1998. View Article : Google Scholar : PubMed/NCBI

16 

O'Connell MB, Madden DM, Murray AM, Heaney RP and Kerzner LJ: Effects of proton pump inhibitors on calcium carbonate absorption in women: A randomized crossover trial. Am J Med. 118:778–781. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Tuukkanen J and Väänänen HK: Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro. Calcif Tissue Int. 38:123–125. 1986. View Article : Google Scholar : PubMed/NCBI

18 

Mizunashi K, Furukawa Y, Katano K and Abe K: Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. Calcif Tissue Int. 53:21–25. 1993. View Article : Google Scholar : PubMed/NCBI

19 

Shin JM, Cho YM and Sachs G: Chemistry of covalent inhibition of the gastric (H+, K+)-ATPase by proton pump inhibitors. J Am Chem Soc. 126:7800–7811. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Sachs G, Shin JM, Vagin O, Lambrecht N, Yakubov I and Munson K: The gastric H,K ATPase as a drug target: Past, present, and future. J Clin Gastroenterol. 41(Suppl 2): S226–S242. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Saitoh T, Fukushima Y, Otsuka H, Hirakawa J, Mori H, Asano T, Ishikawa T, Katsube T, Ogawa K and Ohkawa S: Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers. Aliment Pharmacol Ther. 16:1811–1817. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ohta T, Hashimoto T, Murai H and Kimura H: Influence of proton pump inhibitor on bone metabolism marker. J N Rem Clin. 57:1341–1345. 2008.

23 

Kawai T, Ikeda H, Harada Y and Saitou T: Changes in the rat stomach after long-term administration of proton pump inhibitors (AG-1749 and E-3810). Nihon Rinsho. 50:188–193. 1992.(In Japanese). PubMed/NCBI

24 

Miyashita T, Shah FA, Marti GP, Wang J, Bonde P, Gibson MK, Ohta T, Montgomery EA, Duncan M and Harmon JW: Rabeprazole impedes the development of reflux-induced esophageal cancer in a surgical rat model. Dig Dis Sci. 56:1309–1314. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Savarino V, Di Mario F and Scarpignato C: Proton pump inhibitors in GORD An overview of their pharmacology, efficacy and safety. Pharmacol Res. 59:135–153. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Jacobson BC, Ferris TG, Shea TL, Mahlis EM, Lee TH and Wang TC: Who is using chronic acid suppression therapy and why? Am J Gastroenterol. 98:51–58. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Yang YX, Lewis JD, Epstein S and Metz DC: Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 296:2947–2953. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Vestergaard P, Rejnmark L and Mosekilde L: Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int. 79:76–83. 2006. View Article : Google Scholar : PubMed/NCBI

29 

de Vries F, Cooper AL, Cockle SM, van Staa TP and Cooper C: Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates. Osteoporos Int. 20:1989–1998. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Yu EW, Blackwell T, Ensrud KE, Hillier TA, Lane NE, Orwoll E and Bauer DC: Acid-suppressive medications and risk of bone loss and fracture in older adults. Calcif Tissue Int. 83:251–259. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Roux C, Briot K, Gossec L, Kolta S, Blenk T, Felsenberg D, Reid DM, Eastell R and Glüer CC: Increase in vertebral fracture risk in postmenopausal women using omeprazole. Calcif Tissue Int. 84:13–19. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Ziegler TE, Penniston KL, Alvig AL and Shafer MM: Do proton pump inhibitors decrease calcium absorption? J Bone Miner Res. 25:2786–2795. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Karsdal MA, Henriksen K, Sørensen MG, Gram J, Schaller S, Dziegiel MH, Heegaard AM, Christophersen P, Martin TJ, Christiansen C, et al: Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption. Am J Pathol. 166:467–476. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Niikura K, Takeshita N and Takano M: A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: Potential for clinical application. J Bone Miner Res. 20:1579–1588. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Sheraly AR, Lickorish D, Sarraf F and Davies JE: Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo. Curr Drug Deliv. 6:192–198. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Iwamoto J, Sato Y and Matsumoto H: Influence of gastrectomy on cortical and cancellous bones in rats. Gastroenterol Res Pract. 2013:3816162013. View Article : Google Scholar : PubMed/NCBI

37 

Someya S, Shibata C, Tanaka N, Kudoh K, Naitoh T, Miura K and Unno M: Duodenal switch for intractable reflux gastroesophagitis after proximal gastrectomy. Tohoku J Exp Med. 230:129–132. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Imada T, Rino Y, Takahashi M, Suzuki M, Tanaka J, Shiozawa M, Kabara K, Hatori S, Ito H, Yamamoto Y, et al: Postoperative functional evaluation of pylorus-preserving gastrectomy for early gastric cancer compared with conventional distal gastrectomy. Surgery. 123:165–170. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamasaki Y, Fujimura T, Oyama K, Higashi Y, Hirose A, Tsukada T, Okamoto K, Kinoshita J, Nakamura K, Miyashita T, Miyashita T, et al: Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomed Rep 5: 118-124, 2016.
APA
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T. ... Ohta, T. (2016). Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomedical Reports, 5, 118-124. https://doi.org/10.3892/br.2016.689
MLA
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T., Okamoto, K., Kinoshita, J., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model". Biomedical Reports 5.1 (2016): 118-124.
Chicago
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T., Okamoto, K., Kinoshita, J., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model". Biomedical Reports 5, no. 1 (2016): 118-124. https://doi.org/10.3892/br.2016.689
Copy and paste a formatted citation
x
Spandidos Publications style
Yamasaki Y, Fujimura T, Oyama K, Higashi Y, Hirose A, Tsukada T, Okamoto K, Kinoshita J, Nakamura K, Miyashita T, Miyashita T, et al: Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomed Rep 5: 118-124, 2016.
APA
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T. ... Ohta, T. (2016). Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model. Biomedical Reports, 5, 118-124. https://doi.org/10.3892/br.2016.689
MLA
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T., Okamoto, K., Kinoshita, J., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model". Biomedical Reports 5.1 (2016): 118-124.
Chicago
Yamasaki, Y., Fujimura, T., Oyama, K., Higashi, Y., Hirose, A., Tsukada, T., Okamoto, K., Kinoshita, J., Nakamura, K., Miyashita, T., Tajima, H., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Effects of rabeprazole on bone metabolic disorders in a gastrectomized rat model". Biomedical Reports 5, no. 1 (2016): 118-124. https://doi.org/10.3892/br.2016.689
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