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Article

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

  • Authors:
    • Sara Sanaei
    • Mohammad Hashemi
    • Maryam Rezaei
    • Seyed Mehdi Hashemi
    • Gholamreza Bahari
    • Saeid Ghavami
  • View Affiliations / Copyright

    Affiliations: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 98167, Iran, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167, Iran, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167, Iran, Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
  • Pages: 125-129
    |
    Published online on: May 23, 2016
       https://doi.org/10.3892/br.2016.690
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Abstract

MicroRNAs (miRNAs or miRs) are a family of small non-coding RNAs that function as oncogenes or tumor suppressor genes. Recent evidence suggests that the pri‑miR‑34b/c rs4938723 variant is associated with the development of cancer. At present, there is an inconsistent association between the single‑nucleotide polymorphism in pri-miR-34b/c and cancer in the limited studies. The present study is a case‑control investigation, with 263 breast cancer (BC) patients and 221 control women, which examined the potential association of the pri‑miR‑34b/c rs4938723 polymorphisms with BC susceptibility. The polymorphisms were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. No significant association between the pri‑miR‑34b/c rs4938723 variant and BC was identified [TC vs. TT: Odds ratio (OR), 0.87; 95% confidence interval (CI), 0.60‑1.26; P=0.506; CC vs. TT: OR, 1.22; 95% CI, 0.61‑2.47; P=0.600; TC+CC vs. TT: OR, 0.91; 95% CI, 0.64‑1.31; P=0.648; CC vs. TT+TC: OR, 1.32; 95% CI, 0.67‑2.59; P=0.498; C vs. T: OR, 0.99; 95% CI, 0.75‑1.31; P=0.986]. However, a significant association was observed between the pri‑miR‑34b/c rs4938723 genotypes and clinicopathological characteristics, such a grade, progesterone receptor and human epidermal growth factor receptor 2 status were observed (P<0.05). These findings suggest that the pri‑miR‑34b/c rs4938723 variant may not be a risk factor for the development of BC.
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Copy and paste a formatted citation
Spandidos Publications style
Sanaei S, Hashemi M, Rezaei M, Hashemi SM, Bahari G and Ghavami S: Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk. Biomed Rep 5: 125-129, 2016.
APA
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S.M., Bahari, G., & Ghavami, S. (2016). Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk. Biomedical Reports, 5, 125-129. https://doi.org/10.3892/br.2016.690
MLA
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S. M., Bahari, G., Ghavami, S."Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk". Biomedical Reports 5.1 (2016): 125-129.
Chicago
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S. M., Bahari, G., Ghavami, S."Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk". Biomedical Reports 5, no. 1 (2016): 125-129. https://doi.org/10.3892/br.2016.690
Copy and paste a formatted citation
x
Spandidos Publications style
Sanaei S, Hashemi M, Rezaei M, Hashemi SM, Bahari G and Ghavami S: Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk. Biomed Rep 5: 125-129, 2016.
APA
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S.M., Bahari, G., & Ghavami, S. (2016). Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk. Biomedical Reports, 5, 125-129. https://doi.org/10.3892/br.2016.690
MLA
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S. M., Bahari, G., Ghavami, S."Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk". Biomedical Reports 5.1 (2016): 125-129.
Chicago
Sanaei, S., Hashemi, M., Rezaei, M., Hashemi, S. M., Bahari, G., Ghavami, S."Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk". Biomedical Reports 5, no. 1 (2016): 125-129. https://doi.org/10.3892/br.2016.690
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