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Article Open Access

Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction

  • Authors:
    • Jiang Ke
    • Mou Jing
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, East People's Hospital, Xuzhou, Jiangsu 221000, P.R. China, Department of Cardiology, Xuzhou City Center Hospital, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 155-158
    |
    Published online on: May 26, 2016
       https://doi.org/10.3892/br.2016.692
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Abstract

The aim of the study was to investigate the clinical effect of urinary kallidinogenase combined with edaravone in the treatment of massive cerebral infarction. A total of 58 patients with massive cerebral infarction were admitted to hospital between January 2013 and January 2014. There were 34 male and 24 female patients. The patients were randomly divided into the observation and control groups (n=29 cases per group). The patients in the control group received edaravone treatment, while patients in the observation group were treated with urinary kallidinogenase and edaravone. The clinical effects of the two groups were then compared. The results showed that the National Institutes of Health Stroke Scale score and serum C‑reactive protein level of the patients in the two groups were significantly decreased following treatment. The decreased degree in the observation group was significantly smaller than that in the control group. The difference was statistically significant [(11.03±3.75) vs. (16.58±7.43) scores, P<0.05; (9.88±4.82) vs. (11.98±4.69) mmol/l, P<0.05]. The serum levels of vascular endothelial growth factor were significantly increased in patients of the two groups after treatment. The increased degree in the observation group was significantly higher than that in the control group. The difference was statistically significant [(268.51±77.34) vs. (188.82±57.33) ng/l, P<0.05]. The total effective rate of the observation group was significantly higher than that of the control group and the difference was statistically significant (89.66 vs. 62.07%, P<0.05). In conclusion, urinary kallidinogenase combined with edaravone treatment has a certain clinical curative effect on massive cerebral infarction.
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Copy and paste a formatted citation
Spandidos Publications style
Ke J and Jing M: Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction. Biomed Rep 5: 155-158, 2016.
APA
Ke, J., & Jing, M. (2016). Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction. Biomedical Reports, 5, 155-158. https://doi.org/10.3892/br.2016.692
MLA
Ke, J., Jing, M."Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction". Biomedical Reports 5.2 (2016): 155-158.
Chicago
Ke, J., Jing, M."Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction". Biomedical Reports 5, no. 2 (2016): 155-158. https://doi.org/10.3892/br.2016.692
Copy and paste a formatted citation
x
Spandidos Publications style
Ke J and Jing M: Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction. Biomed Rep 5: 155-158, 2016.
APA
Ke, J., & Jing, M. (2016). Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction. Biomedical Reports, 5, 155-158. https://doi.org/10.3892/br.2016.692
MLA
Ke, J., Jing, M."Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction". Biomedical Reports 5.2 (2016): 155-158.
Chicago
Ke, J., Jing, M."Analysis of treatment effect of urinary kallidinogenase combined with edaravone on massive cerebral infarction". Biomedical Reports 5, no. 2 (2016): 155-158. https://doi.org/10.3892/br.2016.692
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