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Article

Association between the vitamin D receptor gene polymorphism and osteoporosis

  • Authors:
    • Ju Wu
    • De‑Peng Shang
    • Sheng Yang
    • Da‑Peng Fu
    • Hao‑Yi Ling
    • Shuang‑Shuang Hou
    • Jian‑Min Lu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China
  • Pages: 233-236
    |
    Published online on: May 31, 2016
       https://doi.org/10.3892/br.2016.697
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Abstract

The influence of the vitamin D receptor (VDR) gene for the risk of osteoporosis remains to be elucidated. The aim of the present study was to understand the distribution of various single‑nucleotide polymorphisms (SNPs) within the VDR gene and its association with the risk of osteoporosis. In total, 378 subjects without a genetic relationship were recruited to the study between January 2013 and July 2015. The subjects were divided into three groups, which were the normal (n=234), osteoporosis (n=65) and osteoporosis with osteoporotic fracture (n=79) groups. Three pertinent SNPs of the VDR gene rs17879735 (ApaI, Allele A/a, SNP C>A) were examined with polymerase chain reaction‑restriction fragment length polymorphism. The bone mineral density (BMD) of the lumbar spine (L2–L4), femoral neck, Ward's and Tro was measured using dual‑energy X‑ray absorptiometry. The distributions of genotype frequencies aa, AA and Aa were 48.68, 42.86 and 8.46%, separately. Following analysis of each site, BMD, body mass index (BMI) and age, BMD for each site was negatively correlated with age (P<0.01) and positively correlated with BMI (P<0.01). Correction analysis revealed that there were significant differences in the Ward's triangle BMD among each genotype (P<0.05), in which the aa genotype exhibited the lower BMD (P<0.05). No significant difference was identified among the different genotypes in the occurrence of osteoporosis with osteoporotic fracture (P>0.05). In conclusion, these indicated that the VDR gene ApaI polymorphisms had an important role in the osteoporosis risk.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Shang DP, Yang S, Fu DP, Ling HY, Hou SS and Lu JM: Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomed Rep 5: 233-236, 2016.
APA
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., & Lu, J. (2016). Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomedical Reports, 5, 233-236. https://doi.org/10.3892/br.2016.697
MLA
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., Lu, J."Association between the vitamin D receptor gene polymorphism and osteoporosis". Biomedical Reports 5.2 (2016): 233-236.
Chicago
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., Lu, J."Association between the vitamin D receptor gene polymorphism and osteoporosis". Biomedical Reports 5, no. 2 (2016): 233-236. https://doi.org/10.3892/br.2016.697
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Shang DP, Yang S, Fu DP, Ling HY, Hou SS and Lu JM: Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomed Rep 5: 233-236, 2016.
APA
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., & Lu, J. (2016). Association between the vitamin D receptor gene polymorphism and osteoporosis. Biomedical Reports, 5, 233-236. https://doi.org/10.3892/br.2016.697
MLA
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., Lu, J."Association between the vitamin D receptor gene polymorphism and osteoporosis". Biomedical Reports 5.2 (2016): 233-236.
Chicago
Wu, J., Shang, D., Yang, S., Fu, D., Ling, H., Hou, S., Lu, J."Association between the vitamin D receptor gene polymorphism and osteoporosis". Biomedical Reports 5, no. 2 (2016): 233-236. https://doi.org/10.3892/br.2016.697
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