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Article

Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease

  • Authors:
    • Qian Huang
    • Jianhua Yu
    • Xiantu Zhang
    • Shourong Liu
    • Yanyan Ge
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, P.R. China, Department of Infectious Disease, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, P.R. China, Department of Pathology, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, P.R. China, Institute of Liver Disease, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, P.R. China, Department of Internal Medicine, The Third People's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 188-192
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/br.2016.698
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Abstract

Hyperuricemia is significantly associated with and independently predicts the risk for non‑alcoholic fatty liver disease (NAFLD). The aim of the present study was to examine the association of serum uric acid (SUA) levels with liver histology in patients with biopsy-proven NAFLD. Data were collected from 158 adults aged >18 years, and diagnosed with biopsy-proven NAFLD. The differences in liver histology were assessed between hyperuricemic and normal SUA groups with NAFLD to determine the possible risk factors. The SUA level was closely associated with the degree of steatosis (correlation coefficient 0.177, P=0.027). A higher proportion of patients with hyperuricemia showed increased severity of lobular inflammation (lobular inflammation score ≥2) compared with patients exhibiting normal SUA (75 vs. 52.7%; χ2=8.548, P=0.003). Hyperuricemic groups had higher non‑alcoholic steatosis (≥5) compared to the normal SUA groups with NAFLD (48.8 vs. 31.1%; χ2=5.131, P=0.024). Hyperuricemia was independently associated with advanced lobular inflammation (odds ratio, 2.79; 95% confidence interval, 1.250‑6.257; P=0.012) using a logistic regression model controlling for ferritin, serum alanine aminotransferase and aspartate aminotransferase. In conclusion, hyperuricemia is associated with histologically severe NAFLD. Hyperuricemia was independently associated with greater odds of advanced lobular inflammation of NAFLD.
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1 

Jimba S, Nakagami T, Takahashi M, Wakamatsu T, Hirota Y, Iwamoto Y and Wasada T: Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet Med. 22:1141–1145. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Fan JG and Farrell GC: Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol. 50:204–210. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ and Goh KL: Asia-Pacific Working Party on NAFLD: How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol. 22:788–793. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Hjortnaes J, Algra A, Olijhoek J, Huisman M, Jacobs J, van der Graaf Y and Visseren F: Serum uric acid levels and risk for vascular diseases in patients with metabolic syndrome. J Rheumatol. 34:1882–1887. 2007.PubMed/NCBI

5 

Choi HK and Ford ES: Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med. 120:442–447. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Li Y, Xu C, Yu C, Xu L and Miao M: Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study. J Hepatol. 50:1029–1034. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M and Jalal DI: Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 62:392–399. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Lee YJ, Lee HR, Lee JH, Shin YH and Shim JY: Association between serum uric acid and non-alcoholic fatty liver disease in Korean adults. Clin Chem Lab Med. 48:175–180. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Xu C, Yu C, Xu L, Miao M and Li Y: High serum uric acid increases the risk for nonalcoholic Fatty liver disease: A prospective observational study. PLoS One. 5:e115782010. View Article : Google Scholar : PubMed/NCBI

10 

Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, et al: Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose-dependent and -independent fatty liver. J Biol Chem. 287:40732–40744. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, Johnson RJ and Sautin YY: Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 60:1258–1269. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Petta S, Cammà C, Cabibi D, Di Marco V and Craxì A: Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 34:757–766. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Flegal KM, Carroll MD, Kit BK and Ogden CL: Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 307:491–497. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Reynolds K, Gu D, Whelton PK, Wu X, Duan X, Mo J and He J: InterASIA Collaborative Group: Prevalence and risk factors of overweight and obesity in China. Obesity (Silver Spring). 15:10–18. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr and Lenfant C: American Heart Association, National Heart, Lung, and Blood Institute: Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 109:433–438. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Fang J and Alderman MH: Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National Health and Nutrition Examination Survey. JAMA. 283:2404–2410. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, et al: Nonalcoholic Steatohepatitis Clinical Research Network: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–1321. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Sautin YY, Nakagawa T, Zharikov S and Johnson RJ: Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 293:C584–C596. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Xu CF, Yu CH, Xu L, Sa XY and Li YM: Hypouricemic therapy: A novel potential therapeutic option for nonalcoholic fatty liver disease. Hepatology. 52:1865–1866. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Crane JK and Mongiardo KM: Pro-inflammatory effects of uric acid in the gastrointestinal tract. Immunol Invest. 43:255–266. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Martinon F: Signaling by ROS drives inflammasome activation. Eur J Immunol. 40:616–619. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM and Dixit VD: The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 17:179–188. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Kim SM, Lee SH, Kim YG, Kim SY, Seo JW, Choi YW, Kim DJ, Jeong KH, Lee TW, Ihm CG, et al: Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. Am J Physiol Renal Physiol. 308:F993–F1003. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Iracheta-Vellve A, Petrasek J, Satishchandran A, Gyongyosi B, Saha B, Kodys K, Fitzgerald KA, Kurt-Jones EA and Szabo G: Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. J Hepatol. 63:1147–1155. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kanbay M, Huddam B, Azak A, Solak Y, Kadioglu GK, Kirbas I, Duranay M, Covic A and Johnson RJ: A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function. Clin J Am Soc Nephrol. 6:1887–1894. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ogino K, Kato M, Furuse Y, Kinugasa Y, Ishida K, Osaki S, Kinugawa T, Igawa O, Hisatome I, Shigemasa C, et al: Uric acid-lowering treatment with benzbromarone in patients with heart failure: A double-blind placebo-controlled crossover preliminary study. Circ Heart Fail. 3:73–81. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Kanbay M, Ozkara A, Selcoki Y, Isik B, Turgut F, Bavbek N, Uz E, Akcay A, Yigitoglu R and Covic A: Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions. Int Urol Nephrol. 39:1227–1233. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Afzali A, Weiss NS, Boyko EJ and Ioannou GN: Association between serum uric acid level and chronic liver disease in the United States. Hepatology. 52:578–589. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang Q, Yu J, Zhang X, Liu S and Ge Y: Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease. Biomed Rep 5: 188-192, 2016.
APA
Huang, Q., Yu, J., Zhang, X., Liu, S., & Ge, Y. (2016). Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease. Biomedical Reports, 5, 188-192. https://doi.org/10.3892/br.2016.698
MLA
Huang, Q., Yu, J., Zhang, X., Liu, S., Ge, Y."Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease". Biomedical Reports 5.2 (2016): 188-192.
Chicago
Huang, Q., Yu, J., Zhang, X., Liu, S., Ge, Y."Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease". Biomedical Reports 5, no. 2 (2016): 188-192. https://doi.org/10.3892/br.2016.698
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q, Yu J, Zhang X, Liu S and Ge Y: Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease. Biomed Rep 5: 188-192, 2016.
APA
Huang, Q., Yu, J., Zhang, X., Liu, S., & Ge, Y. (2016). Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease. Biomedical Reports, 5, 188-192. https://doi.org/10.3892/br.2016.698
MLA
Huang, Q., Yu, J., Zhang, X., Liu, S., Ge, Y."Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease". Biomedical Reports 5.2 (2016): 188-192.
Chicago
Huang, Q., Yu, J., Zhang, X., Liu, S., Ge, Y."Association of the serum uric acid level with liver histology in biopsy‑proven non-alcoholic fatty liver disease". Biomedical Reports 5, no. 2 (2016): 188-192. https://doi.org/10.3892/br.2016.698
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