Club cell protein 16 as a biomarker in pulmonary contusion

Wu,Feng; Ding,Boying; Yang,Xiaolong; Ma,Dongchun; Zhang,Chaodong; Hua,Congshu

doi:10.3892/br.2016.704

August-2016 Volume 5 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

August-2016 Volume 5 Issue 2

Full Size Image

Article

Club cell protein 16 as a biomarker in pulmonary contusion

Authors:
- Feng Wu
- Boying Ding
- Xiaolong Yang
- Dongchun Ma
- Chaodong Zhang
- Congshu Hua
View Affiliations / Copyright

Affiliations: Department of Cardiothoracic Surgery, Anhui Chest Hospital, Hefei, Anhui 230022, P.R. China, Department of Cardiothoracic Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R China
Pages: 251-253
|
Published online on: June 23, 2016

https://doi.org/10.3892/br.2016.704
Expand metrics +

Abstract

The aim of the present study was to investigate the variation and clinical significance of the 16‑kDa club cell protein (CC16) in patients with pulmonary contusion. A total of 42 patients with pulmonary contusion were divided into experimental groups I (n=24, moderate pulmonary contusion) and II (n=18, severe pulmonary contusion). An enzyme‑linked immunosorbent assay was used to detect the serum levels of CC16 in the two groups of patients within 24 h after the incident and at days 1, 3, 7 and 14 after treatment. The results were compared with another 16 healthy subjects included as the controls. The serum CC16 level at each time point was higher in the two experimental groups compared to the controls (P<0.01). The difference was significant when regarding the levels of CC16 measured within 24 h after contusion and at days 1, 3, 7 and 14 after treatment (P<0.01); however, the levels appeared to decline. In addition, the levels at each time point in experimental group II were significantly higher compared to group I (P<0.01). In conclusion, serum CC16 levels are markedly elevated at the early stage of pulmonary contusion and appear to decrease following treatment. An increase of the CC16 levels is associated with the degree of injury, for which measurement of the levels may serve as a biomarker for evaluation of the serious condition of this pulmonary contusion.

View Figures

View References

1	Blomberg A, Mudway I, Svensson M, Hagenbjörk-Gustafsson A, Thomasson L, Helleday R, Dumont X, Forsberg B, Nordberg G and Bernard A: Clara cell protein as a biomarker for ozone-induced lung injury in humans. Eur Respir J. 22:883–888. 2003. View Article : Google Scholar : PubMed/NCBI
2	Lorraine B and Ware MD: The acute respiratory distress syndrome. N Engl J Med. 34:1334–1349. 2002.
3	Zhang H: Severe chest trauma concurrent adult respiratory distress syndrome from high-risk factors synthetically analyzed. Sichuan Med J. 1:785–786. 2010.
4	Wang Q and Li Z: Research progress in Clara cell protein in lung injury. Chinese Journal of Extracorpor Circulation. 9:57–64. 2011.
5	Allen GS and Coates NE: Pulmonary contusion: A collective review. Am Surg. 62:895–900. 1996.PubMed/NCBI
6	Zhao Y, Cheng C, Yin J, Yang D, Huang T and Huang Y: Experimental study on the volume of irregular foci measured by both modalities of integration and radial line. J Pract Med Imaging. 8:265–266. 2007.
7	Chinese Society of Critical Care Medicine; Chinese Medical Association: Guidelines for management of acute lung injury/acute respiratory distress syndrome: an evidence-based update by the Chinese Society of Critical Care Medicine (2006). Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 18:706–710. 2006.(In Chinese). PubMed/NCBI
8	Nirula R, Diaz JJ Jr, Trunkey DD and Mayberry JC: Rib fracture repair: Indications, technical issues, and future directions. World J Surg. 33:14–22. 2009. View Article : Google Scholar : PubMed/NCBI
9	Sellke FW, del Nido PJ and Swanson SJ: Sabiston and Spencer's surgery of the chest (8th). Saunders Elsevier. Philadelphia, PA: 92–93. 2010.
10	Yu H, Wang C, Wang Z, Fenk K, Yang X, Liu X, Wang Z and Luo J: Severe pulmonary contusion CT image and clinical process classification. China Journal of Emergency Resuscitation and Disaster Medicine. 5:523–524. 2010.
11	Helleday R, Segerstedt B, Forsberg B, Mudway I, Nordberg G, Bernard A and Blomberg A: Exploring the time dependence of serum clara cell protein as a biomarker of pulmonary injury in humans. Chest. 130:672–675. 2006. View Article : Google Scholar : PubMed/NCBI
12	Determann RM, Millo JL, Waddy S, Lutter R, Gerrard CS and Schultz MJ: Plasma CCl6 levels are associated with development of ALI/ARDS in patients with ventilator-associated pneumonia: A retrospective observational study. BMC Pulm Med. 9:492009. View Article : Google Scholar : PubMed/NCBI
13	Wutzler S, Lehnert T, Laurer H, Lehnert M, Becker M, Henrich D, Vogl T and Marzi I: Circulating levels of Clara cell protein 16 but not surfactant protein D identify and quantify lung damage in patients with multiple injuries. J Tranma. 71:E31–36. 2011.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Club cell protein 16 as a biomarker in pulmonary contusion

This article is mentioned in:

Abstract

Related Articles