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Article Open Access

Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer

  • Authors:
    • Lin‑Feng Zheng
    • Wen‑Yong Sun
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    Affiliations: Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 159-164
    |
    Published online on: June 23, 2016
       https://doi.org/10.3892/br.2016.705
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Abstract

Bladder cancer is the most common cancer of the urinary tract. A quarter of bladder cancer patients presenting with muscle‑invasive bladder cancer (MIBC) suffer significant morbidity and succumb to the disease. MicroRNA (miRNA) from tissue, urine or blood samples of MIBC patients have been demonstrated to differ from healthy individuals, and possibly have diagnostic value. The aim of the present meta‑analysis was to access the overall diagnostic accuracy comprehensively and quantitatively. Systematic searching in PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure database was conducted. The pooled sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR) and diagnostic odds ratio (DOR) were calculated via the random effects model to evaluate the overall test performance. Deeks' funnel plot asymmetry test was used to test the publication bias. A total of 10 studies were included in the meta‑analysis, with a total of 577 patients and 412 controls. The pooled sensitivity and specificity were 0.78 [95% confidence interval (CI), 0.69‑0.86] and 0.77 (95% CI, 0.72‑0.81), respectively. The pooled PLR was 2.9 (95% CI, 2.1‑3.8), the NLR was 0.31 (95% CI, 0.27‑0.35), the DOR was 7 (95% CI, 4‑13) and the pooled AUC was 0.80 (95% CI, 0.69‑0.87). In conclusion, the current miRNA assays support their use as markers for MIBC diagnosis.
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View References

1 

Knowles MA and Hurst CD: Molecular biology of bladder cancer: New insights into pathogenesis and clinical diversity. Nat Rev Cancer. 15:25–41. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Xu S, Zhang GM, Guan FJ, Dong DH, Luo L, Li B, Ma XC, Zhao J and Sun LJ: The association between metabolic syndrome and the risk of urothelial carcinoma of the bladder: A case-control study in China. World J Surg Oncol. 13:2362015. View Article : Google Scholar : PubMed/NCBI

3 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Rocken C and Behrens HM: Validating the prognostic and discriminating value of the TNM-classification for gastric cancer - a critical appraisal. Eur J Cancer. 51:577–586. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Eble JN, Sauter G, Epstein JI and Sesterhen IA: World Health Organization Classification of Tumours. Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press. (Lyon). 2004.

6 

Soloway MS: Bladder cancer: Lack of progress in bladder cancer - what are the obstacles? Nat Rev Urol. 10:5–6. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Chamie K and Litwin MS: Quality of bladder cancer care in the USA. Expert Rev Pharmacoecon Outcomes Res. 11:619–621. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Corcoran AT, Handorf E, Canter D, Tomaszewski JJ, Bekelman JE, Kim SP, Uzzo RG, Kutikov A and Smaldone MC: Variation in performance of candidate surgical quality measures for muscle-invasive bladder cancer by hospital type. BJU Int. 115:230–237. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Jayaratna IS, Navai N and Dinney CP: Risk based neoadjuvant chemotherapy in muscle invasive bladder cancer. Transl Androl Urol. 4:273–282. 2015.PubMed/NCBI

10 

Johnson DC, Greene PS and Nielsen ME: Surgical advances in bladder cancer: At what cost? Urol Clin North Am. 42:235–252, ix. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Beitzinger M and Meister G: Preview. MicroRNAs: From decay to decoy. Cell. 140:612–614. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Kent OA and Mendell JT: A small piece in the cancer puzzle: MicroRNAs as tumor suppressors and oncogenes. Oncogene. 25:6188–6196. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Maida Y, Takakura M, Nishiuchi T, Yoshimoto T and Kyo S: Exosomal transfer of functional small RNAs mediates cancer-stroma communication in human endometrium. Cancer Med. 5:304–314. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, Inskoe E, Piroyan A, Sokolsky M, Okolie O, et al: Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine. 12:655–664. 2016.PubMed/NCBI

17 

Catto JW, Miah S, Owen HC, Bryant H, Myers K, Dudziec E, Larré S, Milo M, Rehman I, Rosario DJ, et al: Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res. 69:8472–8481. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Pignot G, Cizeron-Clairac G, Vacher S, Susini A, Tozlu S, Vieillefond A, Zerbib M, Lidereau R, Debre B, Amsellem-Ouazana D, et al: MicroRNA expression profile in a large series of bladder tumors: Identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer. Int J Cancer. 132:2479–2491. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Segersten U, Spector Y, Goren Y, Tabak S and Malmström PU: The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer. Urol Oncol. 32:613–618. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA and Bossuyt PM: QUADAS-2 Group: QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 155:529–536. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Dinnes J, Deeks J, Kirby J and Roderick P: A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy. Health Technol Assess. 9:1–113, iii. 2005. View Article : Google Scholar

22 

Veerla S, Lindgren D, Kvist A, Frigyesi A, Staaf J, Persson H, Liedberg F, Chebil G, Gudjonsson S, Borg A, et al: miRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31. Int J Cancer. 124:2236–2242. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Pignot G, Cizeron-Clairac G, Vacher S, Susini A, Tozlu S, Zerbib M, Lidereau R, Debre B, Amsellem-Ouazana D and Bieche I: MicroRNA expression profile in a large series of bladder tumors: Identification of a 3-miRNA signature predictive of aggressiveness and prognosis of muscle-invasive bladder cancer. Eur Urol Suppl. 11:e1692012. View Article : Google Scholar

24 

Pignot G, Vieillefond A, Vacher S, Zerbib M, Debre B, Lidereau R, Amsellem-Ouazana D and Bieche I: Hedgehog pathway activation in human transitional cell carcinoma of the bladder. Br J Cancer. 106:1177–1186. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Adam L, Wszolek MF, Liu CG, Jing W, Diao L, Zien A, Zhang JD, Jackson D and Dinney CP: Plasma microRNA profiles for bladder cancer detection. Urol Oncol. 31:1701–1708. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Ratert N, Meyer HA, Jung M, Lioudmer P, Mollenkopf HJ, Wagner I, Miller K, Kilic E, Erbersdobler A, Weikert S, et al: miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. J Mol Diagn. 15:695–705. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Li H, Yu G, Shi R, Lang B, Chen X, Xia D, Xiao H, Guo X, Guan W, Ye Z, et al: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy. Mol Cancer. 13:82014. View Article : Google Scholar : PubMed/NCBI

28 

Avgeris M, Mavridis K, Tokas T, Stravodimos K, Fragoulis EG and Scorilas A: Uncovering the clinical utility of miR-143, miR-145 and miR-224 for predicting the survival of bladder cancer patients following treatment. Carcinogenesis. 36:528–537. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Zhang X, Wang L, Dong Z, Du L, Yang Y, Guo Y and Wang C: Downregulation of urinary cell-free microRNA-214 as a diagnostic and prognostic biomarker in bladder cancer. J Surg Oncol. 111:992–999. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Xu Z, Yu YQ, Ge YZ, Zhu JG, Zhu M, Zhao YC, Xu LW, Yang XB, Geng LG, Dou QL, et al: MicroRNA expression profiles in muscle-invasive bladder cancer: Identification of a four-microRNA signature associated with patient survival. Tumour Biol. 36:8159–8166. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Fang Z, Dai W, Wang X, Chen W, Shen C, Ye G and Li L: Circulating miR-205: A promising biomarker for the detection and prognosis evaluation of bladder cancer. Tumour Biol. 37:8075–8082. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Catto JW, Abbod MF, Wild PJ, Linkens DA, Pilarsky C, Rehman I, Rosario DJ, Denzinger S, Burger M, Stoehr R, et al: The application of artificial intelligence to microarray data: Identification of a novel gene signature to identify bladder cancer progression. Eur Urol. 57:398–406. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Silva-Santos RM, Costa-Pinheiro P, Luis A, Antunes L, Lobo F, Oliveira J, Henrique R and Jerónimo C: MicroRNA profile: A promising ancillary tool for accurate renal cell tumour diagnosis. Br J Cancer. 109:2646–2653. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Jiang X, Du L, Wang L, Li J, Liu Y, Zheng G, Qu A, Zhang X, Pan H, Yang Y, et al: Serum microRNA expression signatures identified from genome-wide microRNA profiling serve as novel noninvasive biomarkers for diagnosis and recurrence of bladder cancer. Int J Cancer. 136:854–862. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng LF and Sun WY: Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomed Rep 5: 159-164, 2016.
APA
Zheng, L., & Sun, W. (2016). Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomedical Reports, 5, 159-164. https://doi.org/10.3892/br.2016.705
MLA
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5.2 (2016): 159-164.
Chicago
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5, no. 2 (2016): 159-164. https://doi.org/10.3892/br.2016.705
Copy and paste a formatted citation
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Spandidos Publications style
Zheng LF and Sun WY: Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomed Rep 5: 159-164, 2016.
APA
Zheng, L., & Sun, W. (2016). Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer. Biomedical Reports, 5, 159-164. https://doi.org/10.3892/br.2016.705
MLA
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5.2 (2016): 159-164.
Chicago
Zheng, L., Sun, W."Meta‑analysis of microRNAs as biomarkers for muscle‑invasive bladder cancer". Biomedical Reports 5, no. 2 (2016): 159-164. https://doi.org/10.3892/br.2016.705
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