Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
August-2016 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome

  • Authors:
    • Xiao-Ling Niu
    • Sheng Hao
    • Ping Wang
    • Wei Zhang
    • Gui-Mei Guo
    • Ying Wu
    • Xin-Yu Kuang
    • Guang-Hua Zhu
    • Wen-Yan Huang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology and Rheumatology, Children's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai 200062, P.R. China
  • Pages: 237-242
    |
    Published online on: June 30, 2016
       https://doi.org/10.3892/br.2016.711
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rituximab (RTX) can be used in children with nephrotic syndrome, particularly in those with steroid-dependent nephrotic syndrome (SDNS). However, at present there is no unified standard of how to use RTX, with regard to the amount of doses and frequency, in children with nephrotic syndrome. The study aimed to investigate the therapeutic efficacy of a single dose of RTX in children with steroid‑dependent minimal change nephrotic syndrome (SD-MCNS). The patients with biopsy‑proven minimal change disease (MCD) and clinical features of SDNS received a single dose of RTX (375 mg/m2). The toxicity and side effects of RTX were also observed. The study included 19 patients (10 males and 9 females). Follow-up of the patients was 1-50 months (28.1±16.6 months). B-cell depletion was achieved with RTX infusion (CD20<0.5%) and lasted 1‑6 months (mean, 2.92±1.57 months). During follow‑up, 10 patients remained in complete remission and did not relapse without administration of oral steroids or immunosuppressants for 4-50 months (mean, 30.1±12.6 months), despite recovery of the B-cell count. Nine patients relapsed in the process of reducing steroids, thus, treatment was maintained at a lower dosage (T=0, P<0.05) than prior to use of RTX. The number of relapses also decreased significantly (T=95, P<0.05). Five of the patients relapsed after stopping steroid for several months. At the end of follow-up, the efficacy of a single induction of RTX was 47.4% (9/19). There were no significant side effects associated with administration of RTX. In conclusion, RTX is a safe and effective alternative for children with SD-MCNS. RTX is an effective treatment for the rapid induction of remission and reduces relapse and steroid dependency. A single dose of RTX for children with SD-MCNS is recommended for rapid induction of remission, reduction of long‑term steroid dosage, and decrease in the number of relapses, as it has few side effects.
View Figures

Figure 1

View References

1 

McKinney PA, Feltbower RG, Brocklebank JT and Fitzpatrick MM: Time trends and ethnic patterns of childhood nephrotic syndrome in Yorkshire, UK. Pediatr Nephrol. 16:1040–1044. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Tarshish P, Tobin JN, Bernstein J and Edelmann CM Jr: Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol. 8:769–776. 1997.PubMed/NCBI

3 

Hodson EM, Willis NS and Craig JC: Non-corticosteroid treatment for nephrotic syndrome in children. Cochrane Database Syst Rev. 1:CD0022902008.PubMed/NCBI

4 

Tokunaga M, Saito K, Kawabata D, Imura Y, Fujii T, Nakayamada S, Tsujimura S, Nawata M, Iwata S, Azuma T, et al: Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis. 66:470–475. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Iijima K: Rituximab for childhood refractory nephrotic syndrome. Pediatr Int. 53:617–621. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ravani P, Ponticelli A, Siciliano C, Fornoni A, Magnasco A, Sica F, Bodria M, Caridi G, Wei C, Belingheri M, et al: Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome. Kidney Int. 84:1025–1033. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Kamei K, Ito S, Nozu K, Fujinaga S, Nakayama M, Sako M, Saito M, Yoneko M and Iijima K: Single dose of rituximab for refractory steroid-dependent nephrotic syndrome in children. Pediatr Nephrol. 24:1321–1328. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Gulati A, Sinha A, Jordan SC, Hari P, Dinda AK, Sharma S, Srivastava RN, Moudgil A and Bagga A: Efficacy and safety of treatment with rituximab for difficult steroid-resistant and -dependent nephrotic syndrome: Multicentric report. Clin J Am Soc Nephrol. 5:2207–2212. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Iijima K, Sako M, Nozu K, Mori R, Tuchida N, Kamei K, Miura K, Aya K, Nakanishi K, Ohtomo Y, et al: Rituximab for Childhood-onset Refractory Nephrotic Syndrome (RCRNS) Study Group: Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. 384:1273–1281. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Fujinaga S, Hirano D, Nishizaki N, Kamei K, Ito S, Ohtomo Y, Shimizu T and Kaneko K: Single infusion of rituximab for persistent steroid-dependent minimal-change nephrotic syndrome after long-term cyclosporine. Pediatr Nephrol. 25:539–544. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kidney Disease Improving Global Outcomes: KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int Suppl. 2:139–274. 2012.

12 

Schulman SL, Kaiser BA, Polinsky MS, Srinivasan R and Baluarte HJ: Predicting the response to cytotoxic therapy for childhood nephrotic syndrome: superiority of response to corticosteroid therapy over histopathologic patterns. J Pediatr. 113:996–1001. 1988. View Article : Google Scholar : PubMed/NCBI

13 

Prytuła A, Iijima K, Kamei K, Geary D, Gottlich E, Majeed A, Taylor M, Marks SD, Tuchman S, Camilla R, et al: Rituximab in refractory nephrotic syndrome. Pediatr Nephrol. 25:461–468. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Sun L, Xu H, Shen Q, Cao Q, Rao J, Liu HM, Fang XY and Zhou LJ: Efficacy of rituximab therapy in children with refractory nephrotic syndrome: a prospective observational study in Shanghai. World J Pediatr. 10:59–63. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ito S, Kamei K, Ogura M, Udagawa T, Fujinaga S, Saito M, Sako M and Iijima K: Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome. Pediatr Nephrol. 28:257–264. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tellier S, Brochard K, Garnier A, Bandin F, Llanas B, Guigonis V, Cailliez M, Pietrement C, Dunand O, Nathanson S, et al: Long-term outcome of children treated with rituximab for idiopathic nephrotic syndrome. Pediatr Nephrol. 28:911–918. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Sellier-Leclerc AL, Baudouin V, Kwon T, Macher MA, Guérin V, Lapillonne H, Deschênes G and Ulinski T: Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood - follow-up after CD19 recovery. Nephrol Dial Transplant. 27:1083–1089. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Kemper MJ, Gellermann J, Habbig S, Krmar RT, Dittrich K, Jungraithmayr T, Pape L, Patzer L, Billing H, Weber L, et al: Long-term follow-up after rituximab for steroid-dependent idiopathic nephrotic syndrome. Nephrol Dial Transplant. 27:1910–1915. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Ravani P, Magnasco A, Edefonti A, Murer L, Rossi R, Ghio L, Benetti E, Scozzola F, Pasini A, Dallera N, et al: Short-term effects of rituximab in children with steroid- and calcineurin-dependent nephrotic syndrome: a randomized controlled trial. Clin J Am Soc Nephrol. 6:1308–1315. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Sellier-Leclerc AL, Macher MA, Loirat C, Guérin V, Watier H, Peuchmaur M, Baudouin V and Deschênes G: Rituximab efficiency in children with steroid-dependent nephrotic syndrome. Pediatr Nephrol. 25:1109–1115. 2010. View Article : Google Scholar : PubMed/NCBI

21 

El-Reshaid K, Sallam HT, Hakim AA, Al-Attiyah R and EI-Reshaid K: Rituximab in treatment of idiopathic glomerulopathy. Saudi J Kidney Dis Transpl. 23:973–978. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Samarghitean C, Väliaho J and Vihinen M: Online registry of genetic and clinical immunodeficiency diagnostic laboratories, IDdiagnostics. J Clin Immunol. 24:53–61. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Kyrieleis HA, Löwik MM, Pronk I, Cruysberg HR, Kremer JA, Oyen WJ, van den Heuvel BL, Wetzels JF and Levtchenko EN: Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children. Clin J Am Soc Nephrol. 4:1593–1600. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Kemper MJ, Meyer-Jark T, Lilova M and Müller-Wiefel DE: Combined T- and B-cell activation in childhood steroid-sensitive nephrotic syndrome. Clin Nephrol. 60:242–247. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Cho BS, Yoon SR, Jang JY, Pyun KH and Lee CE: Up-regulation of interleukin-4 and CD23/FcepsilonRII in minimal change nephrotic syndrome. Pediatr Nephrol. 13:199–204. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Kimata H, Fujimoto M and Furusho K: Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome. Eur J Immunol. 25:1497–1501. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Niu X, Hao S, Wang P, Zhang W, Guo G, Wu Y, Kuang X, Zhu G and Huang W: Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome. Biomed Rep 5: 237-242, 2016.
APA
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y. ... Huang, W. (2016). Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome. Biomedical Reports, 5, 237-242. https://doi.org/10.3892/br.2016.711
MLA
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y., Kuang, X., Zhu, G., Huang, W."Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome". Biomedical Reports 5.2 (2016): 237-242.
Chicago
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y., Kuang, X., Zhu, G., Huang, W."Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome". Biomedical Reports 5, no. 2 (2016): 237-242. https://doi.org/10.3892/br.2016.711
Copy and paste a formatted citation
x
Spandidos Publications style
Niu X, Hao S, Wang P, Zhang W, Guo G, Wu Y, Kuang X, Zhu G and Huang W: Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome. Biomed Rep 5: 237-242, 2016.
APA
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y. ... Huang, W. (2016). Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome. Biomedical Reports, 5, 237-242. https://doi.org/10.3892/br.2016.711
MLA
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y., Kuang, X., Zhu, G., Huang, W."Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome". Biomedical Reports 5.2 (2016): 237-242.
Chicago
Niu, X., Hao, S., Wang, P., Zhang, W., Guo, G., Wu, Y., Kuang, X., Zhu, G., Huang, W."Single dose of rituximab in children with steroid-dependent minimal change nephrotic syndrome". Biomedical Reports 5, no. 2 (2016): 237-242. https://doi.org/10.3892/br.2016.711
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team