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Article

Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction

  • Authors:
    • Wiam Hmimech
    • Hind Hassani Idrissi
    • Brehima Diakite
    • Dalila Baghdadi
    • Farah Korchi
    • Rachida Habbal
    • Sellama Nadifi
  • View Affiliations / Copyright

    Affiliations: Laboratory of Genetics and Molecular Pathology, Medical School, University Hassan II, Casablanca BP 9154, Morocco, Department of Cardiology, Ibn Rochd University Hospital Center, Casablanca 20102, Morocco
  • Pages: 361-366
    |
    Published online on: July 13, 2016
       https://doi.org/10.3892/br.2016.717
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Abstract

Myocardial infarction (MI) is a common complex pathology, localized in the main leading causes of mortality worldwide. It is the result of the interaction of genetic and environmental factors. The aim of the present study was to investigate the potential association of C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) (rs1801133) and G20210A factor II prothrombin (FII) (rs1799963) polymorphisms with the susceptibility of MI. Following extraction by the standard salting-out procedure, DNA samples of 100 MI patients and 182 apparently healthy controls were genotyped by polymerase chain reaction‑restriction fragment length polymorphism using HinfI and HindIII restriction enzymes, respectively. The results show a significant association of the G20210T FII polymorphism with the MI risk. The frequencies of the heterozygote genotype GA, homozygous mutated AA and the G20210A allele was higher among patients compared to controls (GA: 59 vs. 5.5%, P<0.001; AA: 10 vs. 0%, P=0.003; and 20210A: 39.5 vs. 2.7%, P<0.003), suggesting that this polymorphism may be a potential genetic marker for MI. No significant association was observed between the C677T MTHFR and MI occurrence, and there was more heterozygote CT in the patient group compared to the controls. As a multifactorial disease, the development of MI may be the result of numerous factors that influence synergistically its occurrence. Thus, further studies are merited to try to better assess these associations (gene-gene and gene-environment interactions).
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Copy and paste a formatted citation
Spandidos Publications style
Hmimech W, Idrissi HH, Diakite B, Baghdadi D, Korchi F, Habbal R and Nadifi S: Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction. Biomed Rep 5: 361-366, 2016.
APA
Hmimech, W., Idrissi, H.H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., & Nadifi, S. (2016). Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction. Biomedical Reports, 5, 361-366. https://doi.org/10.3892/br.2016.717
MLA
Hmimech, W., Idrissi, H. H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., Nadifi, S."Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction". Biomedical Reports 5.3 (2016): 361-366.
Chicago
Hmimech, W., Idrissi, H. H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., Nadifi, S."Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction". Biomedical Reports 5, no. 3 (2016): 361-366. https://doi.org/10.3892/br.2016.717
Copy and paste a formatted citation
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Spandidos Publications style
Hmimech W, Idrissi HH, Diakite B, Baghdadi D, Korchi F, Habbal R and Nadifi S: Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction. Biomed Rep 5: 361-366, 2016.
APA
Hmimech, W., Idrissi, H.H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., & Nadifi, S. (2016). Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction. Biomedical Reports, 5, 361-366. https://doi.org/10.3892/br.2016.717
MLA
Hmimech, W., Idrissi, H. H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., Nadifi, S."Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction". Biomedical Reports 5.3 (2016): 361-366.
Chicago
Hmimech, W., Idrissi, H. H., Diakite, B., Baghdadi, D., Korchi, F., Habbal, R., Nadifi, S."Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction". Biomedical Reports 5, no. 3 (2016): 361-366. https://doi.org/10.3892/br.2016.717
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