Advances in glucose metabolism research in colorectal cancer (Review)
- Authors:
- Sitian Fang
- Xiao Fang
-
Affiliations: Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China - Published online on: July 18, 2016 https://doi.org/10.3892/br.2016.719
- Pages: 289-295
-
Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. Jan 27–2016.(Epub ahead of print). doi: 10.1136/gutjnl-2015-310912. View Article : Google Scholar | |
Cerella C, Gaigneaux A, Dicato M and Diederich M: Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming. Cancer Lett. 356:251–262. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cerella C, Radogna F, Dicato M and Diederich M: Natural compounds as regulators of the cancer cell metabolism. Int J Cell Biol. 2013:6394012013. View Article : Google Scholar : PubMed/NCBI | |
Cerella C, Michiels C, Dashwood RH, Surh YJ and Diederich M: Metabolism and cancer: old and new players. Int J Cell Biol. 2013:2932012013. View Article : Google Scholar : PubMed/NCBI | |
Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI | |
Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JM and Guenther T: Hypoxia-inducible factor-1alpha and −2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. Br J Cancer. 100:1666–1673. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, Kinugasa S, Tachibana M and Nagasue N: Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res. 10:8554–8560. 2004. View Article : Google Scholar : PubMed/NCBI | |
Schmitz KJ, Müller CI, Reis H, Alakus H, Winde G, Baba HA, Wohlschlaeger J, Jasani B, Fandrey J and Schmid KW: Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis. 24:1287–1296. 2009. View Article : Google Scholar : PubMed/NCBI | |
Rajaganeshan R, Prasad R, Guillou PJ, Scott N, Poston G and Jayne DG: Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases. Eur J Surg Oncol. 35:1286–1294. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M and Chayama K: Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer. 105:176–181. 2003. View Article : Google Scholar : PubMed/NCBI | |
Furlan D, Sahnane N, Carnevali I, Cerutti R, Bertoni F, Kwee I, Uccella S, Bertolini V, Chiaravalli AM and Capella C: Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas. Hum Pathol. 39:1483–1494. 2008. View Article : Google Scholar : PubMed/NCBI | |
Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS and Ogino S: HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 176:2292–2301. 2010. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Zhao L, Zhu LT, Wang Y, Pan D, Yao J, You QD and Guo QL: Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. Mol Carcinog. 53(Suppl 1): E107–E118. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kozutsumi Y, Segal M, Normington K, Gething MJ and Sambrook J: The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature. 332:462–464. 1988. View Article : Google Scholar : PubMed/NCBI | |
Xing X, Lai M, Wang Y, Xu E and Huang Q: Overexpression of glucose-regulated protein 78 in colon cancer. Clin Chim Acta. 364:308–315. 2006. View Article : Google Scholar : PubMed/NCBI | |
Takahashi H, Wang JP, Zheng HC, Masuda S and Takano Y: Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis. Histol Histopathol. 26:663–671. 2011.PubMed/NCBI | |
Huang CY, Kuo WT, Huang YC, Lee TC and Yu LC: Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. Cell Death Dis. 4:e6222013. View Article : Google Scholar : PubMed/NCBI | |
Younes M, Lechago LV and Lechago J: Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. Clin Cancer Res. 2:1151–1154. 1996.PubMed/NCBI | |
Haber RS, Rathan A, Weiser KR, Pritsker A, Itzkowitz SH, Bodian C, Slater G, Weiss A and Burstein DE: GLUT1 glucose transporter expression in colorectal carcinoma: A marker for poor prognosis. Cancer. 83:34–40. 1998. View Article : Google Scholar : PubMed/NCBI | |
Korkeila E, Jaakkola PM, Syrjänen K, Pyrhönen S and Sundström J: Pronounced tumour regression after radiotherapy is associated with negative/weak glucose transporter-1 expression in rectal cancer. Anticancer Res. 31:311–315. 2011.PubMed/NCBI | |
Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL and Chen J: AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol. 17:490–499. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li QQ, Sun YP, Ruan CP, Xu XY, Ge JH, He J, Xu ZD, Wang Q and Gao WC: Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival. Cancer Sci. 102:400–406. 2011. View Article : Google Scholar : PubMed/NCBI | |
Song HT, Qin Y, Yao GD, Tian ZN, Fu SB and Geng JS: Astrocyte elevated gene-1 mediates glycolysis and tumorigenesis in colorectal carcinoma cells via AMPK signaling. Mediators Inflamm. 2014:2873812014. View Article : Google Scholar : PubMed/NCBI | |
Qiu SL, Xiao ZC, Piao CM, Xian YL, Jia LX, Qi YF, Han JH, Zhang YY and Du J: AMP-activated protein kinase α2 protects against liver injury from metastasized tumors via reduced glucose deprivation-induced oxidative stress. J Biol Chem. 289:9449–9459. 2014. View Article : Google Scholar : PubMed/NCBI | |
Nam SO, Yotsumoto F, Miyata K, Fukagawa S, Yamada H, Kuroki M and Miyamoto S: Warburg effect regulated by amphiregulin in the development of colorectal cancer. Cancer Med. 4:575–587. 2015. View Article : Google Scholar : PubMed/NCBI | |
Tambe Y, Hasebe M, Kim CJ, Yamamoto A and Inoue H: The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B. Mol Carcinog. 55:52–63. 2016. View Article : Google Scholar : PubMed/NCBI | |
Bernatchez G, Giroux V, Lassalle T, Carpentier AC, Rivard N and Carrier JC: ERRα metabolic nuclear receptor controls growth of colon cancer cells. Carcinogenesis. 34:2253–2261. 2013. View Article : Google Scholar : PubMed/NCBI | |
Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, et al: Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 33:1454–1473. 2014.PubMed/NCBI | |
Diaz-Moralli S, Tarrado-Castellarnau M, Alenda C, Castells A and Cascante M: Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One. 6:e253232011. View Article : Google Scholar : PubMed/NCBI | |
Harrison RA: The detection of hexokinase, glucosephosphate isomerase and phosphoglucomutase activities in polyacrylamide gels after electrophoresis: a novel method using immobilized glucose 6-phosphate dehydrogenase. Anal Biochem. 61:500–507. 1974. View Article : Google Scholar : PubMed/NCBI | |
Tsutsumi S, Fukasawa T, Yamauchi H, Kato T, Kigure W, Morita H, Asao T and Kuwano H: Phosphoglucose isomerase enhances colorectal cancer metastasis. Int J Oncol. 35:1117–1121. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ha TK and Chi SG: CAV1/caveolin 1 enhances aerobic glycolysis in colon cancer cells via activation of SLC2A3/GLUT3 transcription. Autophagy. 8:1684–1685. 2012. View Article : Google Scholar : PubMed/NCBI | |
Tong X, Zhao F, Mancuso A, Gruber JJ and Thompson CB: The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci USA. 106:21660–21665. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ericson NG, Kulawiec M, Vermulst M, Sheahan K, O'Sullivan J, Salk JJ and Bielas JH: Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet. 8:e10026892012. View Article : Google Scholar : PubMed/NCBI | |
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, et al: Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 325:1555–1559. 2009. View Article : Google Scholar : PubMed/NCBI | |
Straus DS: TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol Cancer. 12:782013. View Article : Google Scholar : PubMed/NCBI | |
Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, et al: NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol. 13:1272–1279. 2011. View Article : Google Scholar : PubMed/NCBI | |
Pucci S and Mazzarelli P: MicroRNA dysregulation in colon cancer microenvironment interactions: the importance of small things in metastases. Cancer Microenviron. 4:155–162. 2011. View Article : Google Scholar : PubMed/NCBI | |
Fang R, Xiao T, Fang Z, Sun Y, Li F, Gao Y, Feng Y, Li L, Wang Y, Liu X, et al: MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem. 287:23227–23235. 2012. View Article : Google Scholar : PubMed/NCBI | |
Singh PK, Brand RE and Mehla K: MicroRNAs in pancreatic cancer metabolism. Nat Rev Gastroenterol Hepatol. 9:334–344. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen B, Liu Y, Jin X, Lu W, Liu J, Xia Z, Yuan Q, Zhao X, Xu N and Liang S: MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells. BMC Cancer. 14:4432014. View Article : Google Scholar : PubMed/NCBI | |
Gregersen LH, Jacobsen A, Frankel LB, Wen J, Krogh A and Lund AH: MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells. BMC Cancer. 12:2322012. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Zhao X, Luo M, Zhou Y, Ren W, Wu K, Li X, Shen J and Hu Y: The pro-apoptotic role of the regulatory feedback loop between miR-124 and PKM1/HNF4α in colorectal cancer cells. Int J Mol Sci. 15:4318–4332. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Zhao X, Zhou Y and Hu Y: miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect. Oncol Rep. 28:1346–1352. 2012.PubMed/NCBI | |
Wang J, Wang H, Liu A, Fang C, Hao J and Wang Z: Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer. Oncotarget. 6:19456–19468. 2015. View Article : Google Scholar : PubMed/NCBI | |
He J, Xie G, Tong J, Peng Y, Huang H, Li J, Wang N and Liang H: Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. Cell Biochem Biophys. 70:1343–1350. 2014. View Article : Google Scholar : PubMed/NCBI | |
Li X, Zhao H, Zhou X and Song L: Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil. Mol Med Rep. 11:577–582. 2015.PubMed/NCBI | |
Ellis BC, Graham LD and Molloy PL: CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta. 1843:372–386. 2014. View Article : Google Scholar : PubMed/NCBI | |
Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, Ito Y, Otsuki Y, Uno B, Uchiyama K, et al: MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. Cancer Lett. 363:17–27. 2015. View Article : Google Scholar : PubMed/NCBI | |
Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Matsuhashi N, Futamura M, Ito Y, Otsuki Y, Yoshida K, et al: Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells. Biochim Biophys Acta. 1852:1971–1980. 2015. View Article : Google Scholar : PubMed/NCBI | |
Xu X, Zur Hausen A, Coy JF and Löchelt M: Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer. 124:1330–1337. 2009. View Article : Google Scholar : PubMed/NCBI | |
Shibuya N, Inoue K, Tanaka G, Akimoto K and Kubota K: Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas. Oncology. 88:309–319. 2015. View Article : Google Scholar : PubMed/NCBI | |
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, et al: Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell. 152:599–611. 2013. View Article : Google Scholar : PubMed/NCBI | |
Duffy MJ: Carcinoembryonic antigen as a marker for colorectal cancer: Is it clinically useful? Clin Chem. 47:624–630. 2001.PubMed/NCBI | |
Culverwell AD, Chowdhury FU and Scarsbrook AF: Optimizing the role of FDG PET-CT for potentially operable metastatic colorectal cancer. Abdom Imaging. 37:1021–1031. 2012. View Article : Google Scholar : PubMed/NCBI | |
Xing X, Zhang B, Wang X, Liu F, Shi D and Cheng Y: An ‘imaging-biopsy’ strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials. 48:16–25. 2015. View Article : Google Scholar : PubMed/NCBI | |
Sánchez-Aragó M and Cuezva JM: The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil. J Transl Med. 9:192011. View Article : Google Scholar : PubMed/NCBI | |
Omar HA, Berman-Booty L and Weng JR: Energy restriction: stepping stones towards cancer therapy. Future Oncol. 8:1503–1506. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hursting SD, Dunlap SM, Ford NA, Hursting MJ and Lashinger LM: Calorie restriction and cancer prevention: Α mechanistic perspective. Cancer Metab. 1:102013. View Article : Google Scholar : PubMed/NCBI | |
Chen GQ, Tang CF, Shi XK, Lin CY, Fatima S, Pan XH, Yang DJ, Zhang G, Lu AP, Lin SH, et al: Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. Oncotarget. 6:24148–24162. 2015. View Article : Google Scholar : PubMed/NCBI | |
Arafa SA, Abdelazeem AH, Arab HH and Omar HA: OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro. Acta Pharmacol Sin. 35:394–400. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zwicker F, Kirsner A, Peschke P, Roeder F, Debus J, Huber PE and Weber KJ: Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo. Strahlenther Onkol. 189:684–692. 2013. View Article : Google Scholar : PubMed/NCBI | |
Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L and Spitz DR: Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biol Ther. 8:1228–1236. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ying Q, Ansong E, Diamond AM, Lu Z, Yang W and Bie X: Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways. PLoS One. 10:e01262852015. View Article : Google Scholar : PubMed/NCBI | |
Marimuthu S, Chivukula RS, Alfonso LF, Moridani M, Hagen FK and Bhat GJ: Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: identification of novel targets. Int J Oncol. 39:1273–1283. 2011.PubMed/NCBI |