Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2016 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between OPN genetic variations and nephrolithiasis risk

  • Authors:
    • Xu Xiao
    • Zhenjia Dong
    • Xianqing Ye
    • Yao Yan
    • Xuehua Chen
    • Qin Pan
    • Yongfeng Xie
    • Jie Xie
    • Qiangdong Wang
    • Qinbo Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Huaiyin Hospital of Huai'an City, Huai'an, Jiangsu 223300, P.R. China, Department of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 321-326
    |
    Published online on: July 27, 2016
       https://doi.org/10.3892/br.2016.724
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteopontin (OPN) has an important role in urolithiasis. However, few studies have explored the association between OPN genetic variants and urolithiasis risk. In the present study, three single‑nucleotide polymorphisms (SNPs) (rs28357094, rs11439060 and rs11730582) located on the promoter of OPN were genotyped in a total of 480 individuals, including 230 nephrolithiasis patients and 250 matched healthy controls, and the associations between these SNPs and nephrolithiasis risk in different genetic models was assessed. No significant differences were identified in the genotype and allele frequencies of OPN rs28357094 or rs11730582 (P=0.805 for rs28357094; P=0.577 for rs11730582, respectively). However, carriers with the OPN rs11439060 insertion (ins) types (ins/deletion and ins/ins) were overrepresented in urolithiasis patients compared with the controls [odds ratio (OR), 1.55; 95% confidence interval (CI), 1.08‑2.22]. In the stratified analysis, the increased risk was more evident among younger subjects (adjusted OR, 1.68; 95% CI, 1.01‑2.81), females (2.15; 1.14‑4.08), overweight subjects (1.80; 1.07‑3.05), normotensive subjects (2.48; 1.02‑6.00), abnormal blood sugar subjects (1.58; 1.08‑2.30), smokers (1.63; 1.02‑2.60), and ever‑drinkers (1.98; 1.10‑3.60).. These findings revealed that the OPN rs11439060 polymorphism may act as genetic biomarker for the detection of high‑risk nephrolithiasis patients.
View Figures
View References

1 

Taylor EN, Stampfer MJ and Curhan GC: Diabetes mellitus and the risk of nephrolithiasis. Kidney Int. 68:1230–1235. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Chang IH, Lee YT, Lee DM, Kim TH, Myung SC, Kim YS and Ahn SH: Metabolic syndrome, urine pH, and time-dependent risk of nephrolithiasis in Korean men without hypertension and diabetes. Urology. 78:753–758. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Madore F, Stampfer MJ, Rimm EB and Curhan GC: Nephrolithiasis and risk of hypertension. Am J Hypertens. 11:46–53. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Khan SR: Crystal-induced inflammation of the kidneys: Results from human studies, animal models, and tissue-culture studies. Clin Exp Nephrol. 8:75–88. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Lee YH, Huang WC, Tsai JY, Lu CM, Chen WC, Lee MH, Hsu HS, Huang JK and Chang LS: Epidemiological studies on the prevalence of upper urinary calculi in Taiwan. Urol Int. 68:172–177. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Rittling SR, Matsumoto HN, McKee MD, Nanci A, An XR, Novick KE, Kowalski AJ, Noda M and Denhardt DT: Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res. 13:1101–1111. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Watts RW: Idiopathic urinary stone disease: possible polygenic aetiological factors. QJM. 98:241–246. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Worcester EM and Beshensky AM: Osteopontin inhibits nucleation of calcium oxalate crystals. Ann N Y Acad Sci. 760:375–377. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Tsuji H, Shimizu N, Nozawa M, Umekawa T, Yoshimura K, De Velasco MA, Uemura H and Khan SR: Osteopontin knockdown in the kidneys of hyperoxaluric rats leads to reduction in renal calcium oxalate crystal deposition. Urolithiasis. 42:195–202. 2014.PubMed/NCBI

10 

Giachelli CM, Lombardi D, Johnson RJ, Murry CE and Almeida M: Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol. 152:353–358. 1998.PubMed/NCBI

11 

Umekawa T, Yamate T, Amasaki N, Kohri K and Kurita T: Osteopontin mRNA in the kidney on an experimental rat model of renal stone formation without renal failure. Urol Int. 55:6–10. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Konya E, Umekawa T, Iguchi M and Kurita T: The role of osteopontin on calcium oxalate crystal formation. Eur Urol. 43:564–571. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Chen WC, Lu HF, Chen HY, Hsu CD and Tsai FJ: Arginine form of p21 gene codon 31 is less prominent in patients with calcium oxalate stone. Urol Res. 29:94–97. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Giacopelli F, Marciano R, Pistorio A, Catarsi P, Canini S, Karsenty G and Ravazzolo R: Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics. 20:87–96. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Chiocchetti A, Indelicato M, Bensi T, Mesturini R, Giordano M, Sametti S, Castelli L, Bottarel F, Mazzarino MC, Garbarini L, et al: High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation. Blood. 103:1376–1382. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Marciano R, D'Annunzio G, Minuto N, Pasquali L, Santamaria A, Di Duca M, Ravazzolo R and Lorini R: Association of alleles at polymorphic sites in the Osteopontin encoding gene in young type 1 diabetic patients. Clin Immunol. 131:84–91. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Chiocchetti A, Comi C, Indelicato M, Castelli L, Mesturini R, Bensi T, Mazzarino MC, Giordano M, D'Alfonso S, Momigliano-Richiardi P, et al: Osteopontin gene haplotypes correlate with multiple sclerosis development and progression. J Neuroimmunol. 163:172–178. 2005. View Article : Google Scholar : PubMed/NCBI

18 

D'Alfonso S, Barizzone N, Giordano M, Chiocchetti A, Magnani C, Castelli L, Indelicato M, Giacopelli F, Marchini M, Scorza R, et al: Two single-nucleotide polymorphisms in the 5′ and 3′ ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus. Arthritis Rheum. 52:539–547. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Juge PA, van Steenbergen HW, Constantin A, Tobon GJ, Schaeverbeke T, Gazal S, Combe B, Devauchelle-Pensec V, Nigon D, van der Helm-van Mil AH, et al: SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis. Ann Rheum Dis. 73:1840–1843. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH, Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, et al: The CARDIOGENICS consortium: Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. Ann Rheum Dis. 74:e192015. View Article : Google Scholar : PubMed/NCBI

21 

Glas J, Seiderer J, Bayrle C, Wetzke M, Fries C, Tillack C, Olszak T, Beigel F, Steib C, Friedrich M, et al: The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease. PLoS One. 6:e293092011. View Article : Google Scholar : PubMed/NCBI

22 

Safarinejad MR, Shafiei N and Safarinejad S: Association between polymorphisms in osteopontin gene (SPP1) and first episode calcium oxalate urolithiasis. Urolithiasis. 41:303–313. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Tugcu V, Simsek A, Tarhan T, Atalar F, Bitkin A, Tasci AI, Kural AR and Altug T: OPN gene polymorphism (Ala250) and lower serum OPN levels are associated with urolithiasis. Ren Fail. 35:825–829. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Mo L, Huang HY, Zhu XH, Shapiro E, Hasty DL and Wu XR: Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. Kidney Int. 66:1159–1166. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Kelly DJ, Wilkinson-Berka JL, Ricardo SD, Cox AJ and Gilbert RE: Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats. Nephrol Dial Transplant. 17:985–991. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Vezzoli G, Soldati L and Gambaro G: Update on primary hypercalciuria from a genetic perspective. J Urol. 179:1676–1682. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Shiraga H, Min W, VanDusen WJ, Clayman MD, Miner D, Terrell CH, et al: Inhibition of calcium oxalate crystal growth in vitro by uropontin: Another member of the aspartic acid-rich protein superfamily. Proc Natl Acad Sci USA. 89:426–430. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Mo L, Liaw L, Evan AP, Sommer AJ, Lieske JC and Wu XR: Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both. Am J Physiol Renal Physiol. 293:F1935–F1943. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Lieske JC, Hammes MS, Hoyer JR and Toback FG: Renal cell osteopontin production is stimulated by calcium oxalate monohydrate crystals. Kidney Int. 51:679–686. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Khan SR, Glenton PA and Byer KJ: Modeling of hyperoxaluric calcium oxalate nephrolithiasis: Experimental induction of hyperoxaluria by hydroxy-L-proline. Kidney Int. 70:914–923. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Batinić D, Milosević D, Blau N, Konjevoda P, Stambuk N, Barbarić V, et al: Value of the urinary stone promoters/inhibitors ratios in the estimation of the risk of urolithiasis. J Chem Inf Comput Sci. 40:607–610. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Gao B, Yasui T, Okada A, Tozawa K, Hayashi Y and Kohri K: A polymorphism of the osteopontin gene is related to urinary calcium stones. J Urol. 174:1472–1476. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Liu CC, Huang SP, Tsai LY, Wu WJ, Juo SH, Chou YH, Huang CH and Wu MT: The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis. Clin Chem Acta. 411:739–743. 2010. View Article : Google Scholar

34 

Gao B, Yasui T, Itoh Y, Li Z, Okada A, Tozawa K, Hayashi Y and Kohri K: Association of osteopontin gene haplotypes with nephrolithiasis. Kidney Int. 72:592–598. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Gögebakan B, Igci YZ, Arslan A, Igci M, Erturhan S, Oztuzcu S, Sen H, Demiryürek S, Arikoglu H, Cengiz B, et al: Association between the T-593A and C6982T polymorphisms of the osteopontin gene and risk of developing nephrolithiasis. Arch Med Res. 41:442–448. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao X, Dong Z, Ye X, Yan Y, Chen X, Pan Q, Xie Y, Xie J, Wang Q, Yuan Q, Yuan Q, et al: Association between OPN genetic variations and nephrolithiasis risk. Biomed Rep 5: 321-326, 2016.
APA
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q. ... Yuan, Q. (2016). Association between OPN genetic variations and nephrolithiasis risk. Biomedical Reports, 5, 321-326. https://doi.org/10.3892/br.2016.724
MLA
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q., Xie, Y., Xie, J., Wang, Q., Yuan, Q."Association between OPN genetic variations and nephrolithiasis risk". Biomedical Reports 5.3 (2016): 321-326.
Chicago
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q., Xie, Y., Xie, J., Wang, Q., Yuan, Q."Association between OPN genetic variations and nephrolithiasis risk". Biomedical Reports 5, no. 3 (2016): 321-326. https://doi.org/10.3892/br.2016.724
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X, Dong Z, Ye X, Yan Y, Chen X, Pan Q, Xie Y, Xie J, Wang Q, Yuan Q, Yuan Q, et al: Association between OPN genetic variations and nephrolithiasis risk. Biomed Rep 5: 321-326, 2016.
APA
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q. ... Yuan, Q. (2016). Association between OPN genetic variations and nephrolithiasis risk. Biomedical Reports, 5, 321-326. https://doi.org/10.3892/br.2016.724
MLA
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q., Xie, Y., Xie, J., Wang, Q., Yuan, Q."Association between OPN genetic variations and nephrolithiasis risk". Biomedical Reports 5.3 (2016): 321-326.
Chicago
Xiao, X., Dong, Z., Ye, X., Yan, Y., Chen, X., Pan, Q., Xie, Y., Xie, J., Wang, Q., Yuan, Q."Association between OPN genetic variations and nephrolithiasis risk". Biomedical Reports 5, no. 3 (2016): 321-326. https://doi.org/10.3892/br.2016.724
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team