Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
September-2016 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts

  • Authors:
    • Gary Tse
    • Bing Sun
    • Sheung Ting Wong
    • Vivian Tse
    • Jie Ming Yeo
  • View Affiliations / Copyright

    Affiliations: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China, Department of Cardiology, Tongji University Affiliated Tongji Hospital, Shanghai 200065, P.R. China, School of Medicine, Imperial College London, London SW7 2AZ, UK, Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Copyright: © Tse et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 301-310
    |
    Published online on: August 2, 2016
       https://doi.org/10.3892/br.2016.735
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study examined the ventricular arrhythmic and electrophysiological properties during hyperkalemia (6.3 mM [K+] vs. 4 mM in normokalemia) and anti‑arrhythmic effects of hypercalcemia (2.2 mM [Ca2+]) in Langendorff‑perfused mouse hearts. Monophasic action potential recordings were obtained from the left ventricle during right ventricular pacing. Hyperkalemia increased the proportion of hearts showing provoked ventricular tachycardia (VT) from 0 to 6 of 7 hearts during programmed electrical stimulation (Fisher's exact test, P<0.05). It shortened the epicardial action potential durations (APDx) at 90, 70, 50 and 30% repolarization and ventricular effective refractory periods (VERPs) (analysis of variance, P<0.05) without altering activation latencies. Endocardial APDx and VERPs were unaltered. Consequently, ∆APDx (endocardial APDx‑epicardial APDx) was increased, VERP/latency ratio was decreased and critical intervals for reexcitation (APD90‑VERP) were unchanged. Hypercalcemia treatment exerted anti‑arrhythmic effects during hyperkalemia, reducing the proportion of hearts showing VT to 1 of 7 hearts. It increased epicardial VERPs without further altering the remaining parameters, returning VERP/latency ratio to normokalemic values and also decreased the critical intervals. In conclusion, hyperkalemia exerted pro‑arrhythmic effects by shortening APDs and VERPs. Hypercalcemia exerted anti‑arrhythmic effects by reversing VERP changes, which scaled the VERP/latency ratio and critical intervals.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

No authors listed, . Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 8: Advanced challenges in resuscitation: section 1: Life-threatening electrolyte abnormalities. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Circulation. 102(Suppl 8): I217–I222. 2000.PubMed/NCBI

2 

Gettes LS: Electrolyte abnormalities underlying lethal and ventricular arrhythmias. Circulation. 85(Suppl 1): I70–I76. 1992.PubMed/NCBI

3 

Friedensohn A, Faibel HE, Bairey O, Goldbourt U and Schlesinger Z: Malignant arrhythmias in relation to values of serum potassium in patients with acute myocardial infarction. Int J Cardiol. 32:331–338. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Ahmed MI, Ekundayo OJ, Mujib M, Campbell RC, Sanders PW, Pitt B, Perry GJ, Bakris G, Aban I, Love TE, et al: Mild hyperkalemia and outcomes in chronic heart failure: A propensity matched study. Int J Cardiol. 144:383–388. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Bashour TT and Cheng TO: Evidence for specialized atrioventricular conduction in hyperkalemia. J Electrocardiol. 8:65–68. 1975. View Article : Google Scholar : PubMed/NCBI

6 

Dittrich KL and Walls RM: Hyperkalemia: ECG manifestations and clinical considerations. J Emerg Med. 4:449–455. 1986. View Article : Google Scholar : PubMed/NCBI

7 

Freeman K, Feldman JA, Mitchell P, Donovan J, Dyer KS, Eliseo L, White LF and Temin ES: Effects of presentation and electrocardiogram on time to treatment of hyperkalemia. Acad Emerg Med. 15:239–249. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Cooper WD, Kuan P, Reuben SR and VandenBurg MJ: Cardiac arrhythmias following acute myocardial infarction: Associations with the serum potassium level and prior diuretic therapy. Eur Heart J. 5:464–469. 1984.PubMed/NCBI

9 

Weiner ID and Wingo CS: Hyperkalemia: A potential silent killer. J Am Soc Nephrol. 9:1535–1543. 1998.PubMed/NCBI

10 

Sood MM and Pauly RP: A case of severe hyperkalemia: Fast, safe and effective treatment is required. J Crit Care. 23:431–433. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Kiewiet RM, Ponssen HH, Janssens EN and Fels PW: Ventricular fibrillation in hypercalcaemic crisis due to primary hyperparathyroidism. Neth J Med. 62:94–96. 2004.PubMed/NCBI

12 

Curione M, Letizia C, Amato S, Di Bona S, Di Fazio F, Minisola S, Mazzuoli G and D'Erasmo E: Increased risk of cardiac death in primary hyperparathyroidism: What is a role of electrical instability? Int J Cardiol. 121:200–202. 2007. View Article : Google Scholar : PubMed/NCBI

13 

George SA, Sciuto KJ, Lin J, Salama ME, Keener JP, Gourdie RG and Poelzing S: Extracellular sodium and potassium levels modulate cardiac conduction in mice heterozygous null for the Connexin43 gene. Pflugers Arch. 467:2287–2297. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kodama I, Wilde A, Janse MJ, Durrer D and Yamada K: Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle. J Mol Cell Cardiol. 16:247–259. 1984. View Article : Google Scholar : PubMed/NCBI

15 

Leitch SP and Paterson DJ: Role of Ca2+ in protecting the heart from hyperkalemia and acidosis in the rabbit: Implications for exercise. J Appl Physiol (1985). 77:2391–2399. 1994.PubMed/NCBI

16 

Piktel JS, Wan X, Infeld M, Rosenbaum D and Wilson LD: Beneficial effect of calcium treatment for hyperkalemia is mediated by calcium-dependent conduction, not ‘membrane stabilization’. Ann Emerg Med. 56:S92010. View Article : Google Scholar

17 

Tse G and Yeo JM: Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. Int J Cardiol Heart Vasc. 9:75–82. 2015.PubMed/NCBI

18 

Choy L, Yeo JM, Tse V, Chan SP and Tse G: Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models. Int J Cardiol Heart Vasc. 12:1–10. 2016.

19 

Tse G: Both transmural dispersion of repolarization and transmural dispersion of refractoriness are poor predictors of arrhythmogenicity: A role for the index of Cardiac Electrophysiological Balance (QT/QRS)? J Geriatr Cardiol. (In press). PubMed/NCBI

20 

Tse G, Lai ET, Yeo JM and Yan BP: Electrophysiological mechanisms of Bayés syndrome: Insights from clinical and mouse studies. Front Physiol. May 31–2016.(Epub ahead of print). View Article : Google Scholar

21 

Tse G, Lai ET, Lee AP, Yan BP and Wong SH: Electrophysiological mechanisms of gastrointestinal arrhythmogenesis: Lessons from the heart. Front Physiol. (In press).

22 

Tse G, Lai TH, Yeo JM, Tse V and Wong SH: Mechanisms of electrical activation and conduction in the gastrointestinal system: Lessons from cardiac electrophysiology. Front Physiol. May 31–2016.(Epub ahead of print). View Article : Google Scholar

23 

Tse G, Lai ET, Tse V and Yeo JM: Molecular and electrophysiological mechanisms underlying cardiac arrhythmogenesis in diabetes mellitus. J Diabetes Res. (In press).

24 

Tse G and Yan BP: Novel arrhythmic risk markers incorporating QRS dispersion: QRSd x (Tpeak-Tend)/QRS and QRSd x (Tpeak-Tend)/(QT x QRS). Ann Noninvasive Electrocardiol. (In press).

25 

Tse G: Novel conduction-repolarization indices for the stratification of arrhythmic risk. J Geriatr Cardiol. (In press). PubMed/NCBI

26 

Tse G: (Tpeak-Tend)/QRS and (Tpeak-Tend)/(QT x QRS): Novel markers for predicting arrhythmic risk in Brugada syndrome. Europace. (In press).

27 

Tse G, Wong ST, Tse V, Lee YT, Lin HY and Yeo JM: Cardiac dynamics: alternans and arrhythmogenesis. J Arrhythm. Mar 28–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

28 

Tse G: Mechanisms of cardiac arrhythmias. J Arrhythm. 32:75–81. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Tse G, Tse V and Yeo JM: Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts. Biomed Rep. 4:313–324. 2016.PubMed/NCBI

30 

Tse G, Wong ST, Tse V and Yeo JM: Restitution analysis of alternans using dynamic pacing and its comparison with S1S2 restitution in heptanol-treated, hypokalaemic Langendorff-perfused mouse hearts. Biomed Rep. 4:673–680. 2016.PubMed/NCBI

31 

Tse G, Hothi SS, Grace AA and Huang CL: Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts. J Physiol Sci. 62:79–92. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Tse G, Tse V, Yeo JM and Sun B: Atrial anti-arrhythmic effects of heptanol in Langendorff-perfused mouse hearts. PLoS One. 11:e01488582016. View Article : Google Scholar : PubMed/NCBI

33 

Hogan PM and Spitzer KW: Manganese amd electrogenic phenomena in canine Purkinje fibers. Circ Res. 36:377–391. 1975. View Article : Google Scholar : PubMed/NCBI

34 

Balasubramaniam R, Chawla S, Mackenzie L, Schwiening CJ, Grace AA and Huang CL: Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts. Pflugers Arch. 449:150–158. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Balasubramaniam R, Grace AA, Saumarez RC, Vandenberg JI and Huang CL: Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol. 552:535–546. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Head CE, Balasubramaniam R, Thomas G, Goddard CA, Lei M, Colledge WH, Grace AA and Huang CL: Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol. 16:1329–1340. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Knollmann BC, Katchman AN and Franz MR: Monophasic action potential recordings from intact mouse heart: Validation, regional heterogeneity, and relation to refractoriness. J Cardiovasc Electrophysiol. 12:1286–1294. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Gussak I, Chaitman BR, Kopecky SL and Nerbonne JM: Rapid ventricular repolarization in rodents: Electrocardiographic manifestations, molecular mechanisms, and clinical insights. J Electrocardiol. 33:159–170. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Fabritz L, Kirchhof P, Franz MR, Eckardt L, Mönnig G, Milberg P, Breithardt G and Haverkamp W: Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia. Basic Res Cardiol. 98:25–32. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Sabir IN, Fraser JA, Killeen MJ, Grace AA and Huang CL: The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch. 454:209–222. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Kléber AG and Rudy Y: Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev. 84:431–488. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Thomas GP, Howlett SE and Ferrier GR: Saralasin suppresses arrhythmias in an isolated guinea pig ventricular free wall model of simulated ischemia and reperfusion. J Pharmacol Exp Ther. 274:1379–1386. 1995.PubMed/NCBI

43 

Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert LL, Deakin C, Koster RW, Wyllie J and Böttiger B: ERC Guidelines Writing Group: European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary. Resuscitation. 81:1219–1276. 2010.

44 

Tse G, Wong ST, Tse V and Yeo JM: Depolarization vs. repolarization: What is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts? Acta Physiol (Oxf). Apr 30–2016. View Article : Google Scholar : PubMed/NCBI

45 

Chen Z, Sun B, Tse G, Jiang J and Xu W: Reversibility of both sinus node dysfunction and reduced HCN4 mRNA expression level in an atrial tachycardia pacing model of tachycardia-bradycardia syndrome in rabbit hearts. Int J Clin Exp Pathol. (In press).

46 

Tse G, Wong ST, Tse V and Yeo JM: Determination of action potential wavelength restitution in Scn5a +/− mouse hearts modelling human Brugada syndrome. J Physiol. (In press).

47 

Antzelevitch C: Cellular basis for the repolarization waves of the ECG. Ann N Y Acad Sci. 1080:268–281. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Fisch C: Relation of electrolyte disturbances to cardiac arrhythmias. Circulation. 47:408–419. 1973. View Article : Google Scholar : PubMed/NCBI

49 

Sanguinetti MC and Jurkiewicz NK: Role of external Ca2+ and K+ in gating of cardiac delayed rectifier K+ currents. Pflugers Arch. 420:180–186. 1992. View Article : Google Scholar : PubMed/NCBI

50 

Sanguinetti MC, Jiang C, Curran ME and Keating MT: A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81:299–307. 1995. View Article : Google Scholar : PubMed/NCBI

51 

Kishida H, Surawicz B and Fu LT: Effects of K+ and K+-induced polarization on (dV/dt)max, threshold potential, and membrane input resistance in guinea pig and cat ventricular myocardium. Circ Res. 44:800–814. 1979. View Article : Google Scholar : PubMed/NCBI

52 

Dominguez G and Fozzard HA: Influence of extracellular K+ concentration on cable properties and excitability of sheep cardiac Purkinje fibers. Circ Res. 26:565–574. 1970. View Article : Google Scholar : PubMed/NCBI

53 

Ettinger PO, Regan TJ and Oldewurtel HA: Hyperkalemia, cardiac conduction, and the electrocardiogram: A review. Am Heart J. 88:360–371. 1974. View Article : Google Scholar : PubMed/NCBI

54 

Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, MahautSmith MP, Colledge WH, Grace AA and Huang CL: Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf). 189:33–46. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Nerbonne JM and Guo W: Heterogeneous expression of voltage-gated potassium channels in the heart: Roles in normal excitation and arrhythmias. J Cardiovasc Electrophysiol. 13:406–409. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Antzelevitch C: Transmural dispersion of repolarization and the T wave. Cardiovasc Res. 50:426–431. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Yan GX and Martin J: Electrocardiographic T wave: A symbol of transmural dispersion of repolarization in the ventricles. J Cardiovasc Electrophysiol. 14:639–640. 2003. View Article : Google Scholar : PubMed/NCBI

58 

Mines GR: On dynamic equilibrium in the heart. J Physiol. 46:349–383. 1913. View Article : Google Scholar : PubMed/NCBI

59 

Weidmann S: Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres. J Physiol. 129:568–582. 1955. View Article : Google Scholar : PubMed/NCBI

60 

Hélie F, Cossette J, Vermeulen M and Cardinal R: Differential effects of lignocaine and hypercalcaemia on anisotropic conduction and reentry in the ischaemically damaged canine ventricle. Cardiovasc Res. 29:359–372. 1995. View Article : Google Scholar : PubMed/NCBI

61 

Corlew DS, Bryda SL, Bradley EL III and DiGirolamo M: Observations on the course of untreated primary hyperparathyroidism. Surgery. 98:1064–1071. 1985.PubMed/NCBI

62 

Rosenqvist M, Nordenström J, Andersson M and Edhag OK: Cardiac conduction in patients with hypercalcaemia due to primary hyperparathyroidism. Clin Endocrinol (Oxf). 37:29–33. 1992. View Article : Google Scholar : PubMed/NCBI

63 

Parham WA, Mehdirad AA, Biermann KM and Fredman CS: Hyperkalemia revisited. Tex Heart Inst J. 33:40–47. 2006.PubMed/NCBI

64 

Rumancik WM, Denlinger JK, Nahrwold ML and Falk RB Jr: The QT interval and serum ionized calcium. JAMA. 240:366–368. 1978. View Article : Google Scholar : PubMed/NCBI

65 

Scheidegger D and Drop LJ: The relationship between duration of Q-T interval and plasma ionized calcium concentration: Experiments with acute, steady-state [Ca++] changes in the dog. Anesthesiology. 51:143–148. 1979. View Article : Google Scholar : PubMed/NCBI

66 

Wortsman J and Frank S: The QT interval in clinical hypercalcemia. Clin Cardiol. 4:87–90. 1981. View Article : Google Scholar : PubMed/NCBI

67 

Killeen MJ, Thomas G, Sabir IN, Grace AA and Huang CL: Mouse models of ventricular arrhythmias. Acta Physiol (Oxf). 192:455–469. 2008. View Article : Google Scholar : PubMed/NCBI

68 

Nerbonne JM and Kass RS: Molecular physiology of cardiac repolarization. Physiol Rev. 85:1205–1253. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Hsieh YC, Lin JC, Hung CY, Li CH, Lin SF, Yeh HI, Huang JL, Lo CP, Haugan K, Larsen BD, et al: Gap junction modifier rotigaptide decreases the susceptibility to ventricular arrhythmia by enhancing conduction velocity and suppressing discordant alternans during therapeutic hypothermia in isolated rabbit hearts. Heart Rhythm. 13:251–261. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Wu TJ, Lin SF, Weiss JN, Ting CT and Chen PS: Two types of ventricular fibrillation in isolated rabbit hearts: Importance of excitability and action potential duration restitution. Circulation. 106:1859–1866. 2002. View Article : Google Scholar : PubMed/NCBI

71 

Osadchii OE: Effects of ventricular pacing protocol on electrical restitution assessments in guinea-pig heart. Exp Physiol. 97:807–821. 2012. View Article : Google Scholar : PubMed/NCBI

72 

Osadchii OE, Larsen AP and Olesen SP: Predictive value of electrical restitution in hypokalemia-induced ventricular arrhythmogenicity. Am J Physiol Heart Circ Physiol. 298:H210–H220. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Osadchii OE: Mechanisms of hypokalemia-induced ventricular arrhythmogenicity. Fundam Clin Pharmacol. 24:547–559. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Osadchii OE, Bentzen BH and Olesen SP: Chamber-specific effects of hypokalaemia on ventricular arrhythmogenicity in isolated, perfused guinea-pig heart. Exp Physiol. 94:434–446. 2009. View Article : Google Scholar : PubMed/NCBI

75 

Osadchii OE and Olesen SP: Electrophysiological determinants of hypokalaemia-induced arrhythmogenicity in the guinea-pig heart. Acta Physiol (Oxf). 197:273–287. 2009. View Article : Google Scholar : PubMed/NCBI

76 

Osadchii OE: Flecainide attenuates rate adaptation of ventricular repolarization in guinea-pig heart. Scand Cardiovasc J. 50:28–35. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Osadchii OE: Impact of hypokalemia on electromechanical window, excitation wavelength and repolarization gradients in guinea-pig and rabbit hearts. PLoS One. 9:e1055992014. View Article : Google Scholar : PubMed/NCBI

78 

Osadchii OE: Impaired epicardial activation-repolarization coupling contributes to the proarrhythmic effects of hypokalaemia and dofetilide in guinea pig ventricles. Acta Physiol (Oxf). 211:48–60. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Osadchii OE: Flecainide-induced proarrhythmia is attributed to abnormal changes in repolarization and refractoriness in perfused guinea-pig heart. J Cardiovasc Pharmacol. 60:456–466. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Hsieh YC, Lin SF, Lin TC, Ting CT and Wu TJ: Therapeutic hypothermia (30 degrees C) enhances arrhythmogenic substrates, including spatially discordant alternans, and facilitates pacing-induced ventricular fibrillation in isolated rabbit hearts. Circ J. 73:2214–2222. 2009. View Article : Google Scholar : PubMed/NCBI

81 

Franz MR, Burkhoff D, Spurgeon H, Weisfeldt ML and Lakatta EG: In vitro validation of a new cardiac catheter technique for recording monophasic action potentials. Eur Heart J. 7:34–41. 1986.PubMed/NCBI

82 

Hoffman BF, Cranefield PF, Lepeschkin E, Surawicz B and Herrlich HC: Comparison of cardiac monophasic action potentials recorded by intracellular and suction electrodes. Am J Physiol. 196:1297–1301. 1959.PubMed/NCBI

83 

Tse G, Wong ST, Tse V and Yeo JM, Lin HY and Yeo JM: Monophasic action potential recordings: Which is the recording electrode? J Basic Clin Physiol Pharmacol. Apr 30–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

84 

Tse G, Ali A, Alpendurada F, Prasad S, Raphael CE and Vassiliou V: Tuberculous Constrictive Pericarditis. Res Cardiovasc Med. 4:e296142015. View Article : Google Scholar : PubMed/NCBI

85 

Tse G, Ali A, Prasad SK, Vassiliou V and Raphael CE: Atypical case of post-partum cardiomyopathy: an overlap syndrome with arrhythmogenic right ventricular cardiomyopathy? BJR|case reports. 1:201501822015. View Article : Google Scholar

86 

Vassiliou V, Chin C, Perperoglou A, Tse G, Ali A, Raphael C, Jabbour A, Newby D, Pennell D, Dweck M and Prasad S: 93 Ejection Fraction by Cardiovascular Magnetic Resonance Predicts Adverse Outcomes Post Aortic Valve Replacement. Heart. 100(Suppl 3): A53–A54. 2014. View Article : Google Scholar

87 

Kwong JS, Leithäuser B, Park JW and Yu CM: Diagnostic value of magnetocardiography in coronary artery disease and cardiac arrhythmias: A review of clinical data. Int J Cardiol. 167:1835–1842. 2013. View Article : Google Scholar : PubMed/NCBI

88 

Steinhoff U, KnappeGrueneberg S, Schnabel A, Trahms L, Smith F, Langley P, Murray A and Koch H: Magnetocardiography for pharmacology safety studies requiring high patient throughput and reliability. J Electrocardiol. 37(Suppl): 187–192. 2004. View Article : Google Scholar : PubMed/NCBI

89 

Yoshida K, Ogata K, Inaba T, Nakazawa Y, Ito Y, Yamaguchi I, Kandori A and Aonuma K: Ability of magnetocardiography to detect regional dominant frequencies of atrial fibrillation. J Arrhythm. 31:345–351. 2015. View Article : Google Scholar : PubMed/NCBI

90 

Ito Y, Shiga K, Yoshida K, Ogata K, Kandori A, Inaba T, Nakazawa Y, Sekiguchi Y, Tada H, Sekihara K, et al: Development of a magnetocardiography-based algorithm for discrimination between ventricular arrhythmias originating from the right ventricular outflow tract and those originating from the aortic sinus cusp: A pilot study. Heart Rhythm. 11:1605–1612. 2014. View Article : Google Scholar : PubMed/NCBI

91 

Sato Y, Yoshida K, Ogata K, Inaba T, Tada H, Sekiguchi Y, Ito Y, Ishizu T, Seo Y, Yamaguchi I, et al: An increase in right atrial magnetic strength is a novel predictor of recurrence of atrial fibrillation after radiofrequency catheter ablation. Circ J. 76:1601–1608. 2012. View Article : Google Scholar : PubMed/NCBI

92 

Tse G, Wong ST, Tse V and Yeo JM: Variability in local action potential durations, dispersion of repolarization and wavelength restitution in aged wild-type and Scn5a+/− mouse hearts modelling human Brugada syndrome. Journal of Geriatric Cardiology. (In press). PubMed/NCBI

93 

Tse G, Yeo JM, Tse V and Sun B: Gap junction inhibition by heptanol increases ventricular arrhythmogenicity by decreasing conduction velocity without affecting repolarization properties or myocardial refractoriness in Langendorff-perfused mouse hearts. MMR. (In Press).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tse G, Sun B, Wong ST, Tse V and Yeo JM: Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts. Biomed Rep 5: 301-310, 2016.
APA
Tse, G., Sun, B., Wong, S.T., Tse, V., & Yeo, J.M. (2016). Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts. Biomedical Reports, 5, 301-310. https://doi.org/10.3892/br.2016.735
MLA
Tse, G., Sun, B., Wong, S. T., Tse, V., Yeo, J. M."Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts". Biomedical Reports 5.3 (2016): 301-310.
Chicago
Tse, G., Sun, B., Wong, S. T., Tse, V., Yeo, J. M."Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts". Biomedical Reports 5, no. 3 (2016): 301-310. https://doi.org/10.3892/br.2016.735
Copy and paste a formatted citation
x
Spandidos Publications style
Tse G, Sun B, Wong ST, Tse V and Yeo JM: Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts. Biomed Rep 5: 301-310, 2016.
APA
Tse, G., Sun, B., Wong, S.T., Tse, V., & Yeo, J.M. (2016). Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts. Biomedical Reports, 5, 301-310. https://doi.org/10.3892/br.2016.735
MLA
Tse, G., Sun, B., Wong, S. T., Tse, V., Yeo, J. M."Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts". Biomedical Reports 5.3 (2016): 301-310.
Chicago
Tse, G., Sun, B., Wong, S. T., Tse, V., Yeo, J. M."Anti-arrhythmic effects of hypercalcemia in hyperkalemic, Langendorff-perfused mouse hearts". Biomedical Reports 5, no. 3 (2016): 301-310. https://doi.org/10.3892/br.2016.735
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team