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Article

Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study

  • Authors:
    • Feng‑Fei Li
    • Li‑Yuan Fu
    • Xiao‑Hua Xu
    • Xiao‑Fei Su
    • Jin‑Dan Wu
    • Lei Ye
    • Jian‑Hua Ma
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210012, P.R. China, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Republic of Singapore
  • Pages: 461-466
    |
    Published online on: August 25, 2016
       https://doi.org/10.3892/br.2016.744
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Abstract

The aim of the present study was to evaluate the add‑on effect of acarbose therapy in oxidative stress, and the lipid and inflammatory profiles of patients with type 2 diabetes mellitus (T2DM) treated with insulin. This was an open and unblended study. Patients (n=134) with T2DM (haemoglobin A1c range, 9.0‑12.0%) were recruited. After continuous subcutaneous insulin infusion for 7 days for initial rapid correction of hyperglycaemia, a premixed insulin titration period (duration, 4‑6 days) subsequently followed. Patients were then randomized (1:1) into two groups as follows: An acarbose plus pre‑mixed 30/70 insulin group or a pre‑mixed 30/70 insulin only group; each group received treatment for 2 weeks. Plasma high‑sensitivity C‑reactive protein (Hs‑CRP), 8‑iso‑prostaglandin F2α (8‑iso PGF2α), tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β, and IL‑6 levels were measured before and after therapy. Patients that received acarbose plus insulin demonstrated greater reduction in 8‑iso PGF2α, Hs‑CRP, TNF‑α, IL‑1β and IL‑6 levels when compared with the insulin only patients. Thus, acarbose add‑on insulin therapy was identified to be associated with greater improvements in oxidative stress and inflammation in patients with T2DM when compared with those that received insulin only therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Li FF, Fu LY, Xu XH, Su XF, Wu JD, Ye L and Ma JH: Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study. Biomed Rep 5: 461-466, 2016.
APA
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., & Ma, J. (2016). Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study. Biomedical Reports, 5, 461-466. https://doi.org/10.3892/br.2016.744
MLA
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., Ma, J."Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study". Biomedical Reports 5.4 (2016): 461-466.
Chicago
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., Ma, J."Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study". Biomedical Reports 5, no. 4 (2016): 461-466. https://doi.org/10.3892/br.2016.744
Copy and paste a formatted citation
x
Spandidos Publications style
Li FF, Fu LY, Xu XH, Su XF, Wu JD, Ye L and Ma JH: Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study. Biomed Rep 5: 461-466, 2016.
APA
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., & Ma, J. (2016). Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study. Biomedical Reports, 5, 461-466. https://doi.org/10.3892/br.2016.744
MLA
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., Ma, J."Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study". Biomedical Reports 5.4 (2016): 461-466.
Chicago
Li, F., Fu, L., Xu, X., Su, X., Wu, J., Ye, L., Ma, J."Analysis of the add-on effect of α-glucosidase inhibitor, acarbose in insulin therapy: A pilot study". Biomedical Reports 5, no. 4 (2016): 461-466. https://doi.org/10.3892/br.2016.744
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