Elevated serum levels of two anti-neutrophil cytoplasmic antibodies in a lung cancer patient: A case report

Okauchi,Shinichiro; Tamura,Tomohiro; Kagohashi,Katsunori; Kawaguchi,Mio; Satoh,Hiroaki

doi:10.3892/br.2016.750

October-2016 Volume 5 Issue 4

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October-2016 Volume 5 Issue 4

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Case Report

Elevated serum levels of two anti-neutrophil cytoplasmic antibodies in a lung cancer patient: A case report

Authors:
- Shinichiro Okauchi
- Tomohiro Tamura
- Katsunori Kagohashi
- Mio Kawaguchi
- Hiroaki Satoh
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
Pages: 511-513
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Published online on: September 6, 2016

https://doi.org/10.3892/br.2016.750
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Abstract

A 71-year-old woman with arthralgia and lung fibrosis was referred to Mito Kyodo General Hospital (Mito, Japan) for a mass, which was incidentally observed on a chest radiograph. The chest computed tomography scan demonstrated fibrotic lesions in the lower lobes of the lung and a nodule in the left upper lobe. The serum levels of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) and proteinase 3 (PR3)-ANCA were 60.3 and 7.5 U/ml, respectively. A transbronchial biopsy obtained from the nodule in the left upper lobe of the lung revealed a lung adenocarcinoma and the patient underwent standard upper lobectomy of the left lung. Subsequent to the resection, the serum levels of PR3-ANCA and MPO-ANCA returned to 10.0 and <1.0 U/ml, respectively. Notably, titers of antinuclear antibodies were also decreased during the postoperative course. Although elevated serum ANCA levels are rarely seen in lung cancer, they may be associated with the occurrence of lung cancer in certain patients, as observed in the present case.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Elevated serum levels of two anti-neutrophil cytoplasmic antibodies in a lung cancer patient: A case report

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