Early prophylactic anticoagulation for portal vein system thrombosis after splenectomy: A systematic review and meta-analysis

Zhang,Ning; Yao,Yingmin; Xue,Wanli; Wu,Shengli

doi:10.3892/br.2016.755

October-2016 Volume 5 Issue 4

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October-2016 Volume 5 Issue 4

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Article

Early prophylactic anticoagulation for portal vein system thrombosis after splenectomy: A systematic review and meta-analysis

Authors:
- Ning Zhang
- Yingmin Yao
- Wanli Xue
- Shengli Wu
View Affiliations / Copyright

Affiliations: Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, P.R. China
Pages: 483-490
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Published online on: September 9, 2016

https://doi.org/10.3892/br.2016.755
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Abstract

A systematic review and meta-analysis were conducted to evaluate the efficacy and safety of early prophylactic anticoagulation for the prevention of portal vein system thrombosis (PVST) after splenectomy. A systematic search of the PubMed, EMBASE, Springer and Cochrane Library databases was performed to identify studies comparing the outcomes in patients receiving or not receiving regular prophylactic anticoagulation after splenectomy. The quality of the included studies was assessed using the Jadad Score and the Newcastle‑Ottawa Scale. Heterogeneity was evaluated using the χ2 and I2 tests. The parameters that were analyzed included the incidence of PVST and anticoagulation‑associated complications. A total of seven studies qualified for the review, involving 383 and 283 patients receiving or not receiving regular prophylactic anticoagulation, respectively. The incidence of PVST was significantly reduced with an odds ratio (OR) of 0.31 [95% confidence interval (CI), 0.21‑0.46; P<0.00001] in the regular prophylactic anticoagulation group compared with the control group. No difference in the incidence of anticoagulation‑associated complications was identified between the two groups (OR=0.60, 95% CI, 0.23‑1.56; P=0.30). Early prophylactic anticoagulation was associated with a reduced incidence of PVST, although it was not associated with the incidence of anticoagulation‑associated complications. These results indicate that prophylactic anticoagulation could be safely administered after splenectomy, even to cirrhotic patients.

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