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Article

Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma

  • Authors:
    • Feng Jiang
    • Wei Hu
    • Bicheng Zhang
    • Jing Xu
    • Yongjie Shui
    • Xiaofeng Zhou
    • Xiaoqiu Ren
    • Xiaozhong Chen
    • Li Shen
    • Qichun Wei
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, National Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 437-442
    |
    Published online on: September 12, 2016
       https://doi.org/10.3892/br.2016.757
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Abstract

In the era of intensity-modulated radiotherapy, distant metastasis is currently the main cause of treatment failure for nasopharyngeal carcinoma (NPC). Additional therapeutic strategies are required to control the metastasis and improve survival. One strategy is targeted therapy, for example against c‑Kit. In the current study, the frequency of c‑Kit expression was determined immunohistochemically in 106 NPC patients. c‑Kit expression changes during the course of radiation therapy were detected in 41 cases via weekly biopsy. Twelve cases (11.3%) had c‑Kit expression scores of 3+ and 16 (15.1%) had scores of 2+. Thus, c‑Kit overexpression (2+ or 3+) was observed in 28 (26.4%) patients. There were 35 (33.0%) and 43 (40.6%) patients with c‑Kit expression scores of 1+ and 0, respectively. Furthermore, a trend of decreased c‑Kit expression was observed after commencing radiotherapy according to the 41 NPC patients who were biopsied weekly. Therefore, c‑Kit overexpression was identified to be common in NPC, and evaluating c‑Kit as a therapeutic target for metastatic NPC via c‑Kit overexpression subsequent to first line treatment may be of interest. To the best of our knowledge, the present study is the first to demonstrate a trend of decreased c‑Kit expression during the course of radiotherapy.
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View References

1 

Chang ET and Adami HO: The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15:1765–1777. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Wang JB, Jiang Y, Liang H, Li P, Xiao HJ, Ji J, Xiang W, Shi JF, Fan YG, Li L, et al: Attributable causes of cancer in China. Ann Oncol. 23:2983–2989. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Jia WH, Huang QH, Liao J, Ye W, Shugart YY, Liu Q, Chen LZ, Li YH, Lin X, Wen FL, et al: Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China. BMC Cancer. 6:1782006. View Article : Google Scholar : PubMed/NCBI

5 

Yi JL, Gao L, Huang XD, Li SY, Luo JW, Cai WM, Xiao JP and Xu GZ: Nasopharyngeal carcinoma treated by radical radiotherapy alone: Ten-year experience of a single institution. Int J Radiat Oncol Biol Phys. 65:161–168. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Ong YK, Heng DM, Chung B, Leong SS, Wee J, Fong KW, Tan T and Tan EH: Design of a prognostic index score for metastatic nasopharyngeal carcinoma. Eur J Cancer. 39:1535–1541. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, Sun Y, Lin AH, Liu MZ and Ma J: How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys. 80:661–668. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lee AW, Sze WM, Au JS, Leung SF, Leung TW, Chua DT, Zee BC, Law SC, Teo PM, Tung SY, et al: Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience. Int J Radiat Oncol Biol Phys. 61:1107–1116. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Hui EP, Leung SF, Au JS, Zee B, Tung S, Chua D, Sze WM, Law CK, Leung TW and Chan AT: Lung metastasis alone in nasopharyngeal carcinoma: A relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group. Cancer. 101:300–306. 2004.

10 

Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U and Ullrich A: Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6:3341–3351. 1987.PubMed/NCBI

11 

Dagher R, Cohen M, Williams G, Rothmann M, Gobburu J, Robbie G, Rahman A, Chen G, Staten A, Griebel D, et al: Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res. 8:3034–3038. 2002.PubMed/NCBI

12 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 7th. Wiley Blackwell; Chichester: 2010

13 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A III: American Joint Committee on Cancer (AJCC)Cancer staging manual. 7th. Springer; New York: 2010

14 

Bar-Sela G, Kuten A, Ben-Eliezer S, Gov-Ari E and Ben-Izhak O: Expression of HER2 and C-KIT in nasopharyngeal carcinoma: Implications for a new therapeutic approach. Mod Pathol. 16:1035–1040. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Bar-Sela G, Ben Arush MW, Sabo E, Kuten A, Minkov I and Ben-Izhak O: Pediatric nasopharyngeal carcinoma: Better prognosis and increased c-Kit expression as compared to adults. Pediatr Blood Cancer. 45:291–297. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Sheu LF, Lee WC, Lee HS, Kao WY and Chen A: Co-expression of c-kit and stem cell factor in primary and metastatic nasopharyngeal carcinomas and nasopharyngeal epithelium. J Pathol. 207:216–223. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Charfi S, Khabir A, Ayadi L, Mseddi M, Makni H, Gorbel A, Daoud J, Frikha M, Jlidi R, Busson P, et al: Expression of c-kit in North African nasopharyngeal carcinomas: Correlation with age and LMP1. Cancer Radiother. 11:247–251. 2007.(In French). View Article : Google Scholar : PubMed/NCBI

18 

Rohr UP, Rehfeld N, Pflugfelder L, Geddert H, Müller W, Steidl U, Fenk R, Gräf T, Schott M, Thiele KP, et al: Expression of the tyrosine kinase c-kit is an independent prognostic factor in patients with small cell lung cancer. Int J Cancer. 111:259–263. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Huang PY, Hong MH, Zhang X, Mai HQ, Luo DH and Zhang L: C-KIT overexpression and mutation in nasopharyngeal carcinoma cell lines and reactivity of Imatinib on these cell lines. Chin J Cancer. 29:131–135. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Hui EP, Lui VW, Wong CS, Ma BB, Lau CP, Cheung CS, Ho K, Cheng SH, Ng MH and Chan AT: Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma. Invest New Drugs. 29:1123–1131. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang F, Hu W, Zhang B, Xu J, Shui Y, Zhou X, Ren X, Chen X, Shen L, Wei Q, Wei Q, et al: Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma. Biomed Rep 5: 437-442, 2016.
APA
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X. ... Wei, Q. (2016). Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma. Biomedical Reports, 5, 437-442. https://doi.org/10.3892/br.2016.757
MLA
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X., Ren, X., Chen, X., Shen, L., Wei, Q."Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma". Biomedical Reports 5.4 (2016): 437-442.
Chicago
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X., Ren, X., Chen, X., Shen, L., Wei, Q."Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma". Biomedical Reports 5, no. 4 (2016): 437-442. https://doi.org/10.3892/br.2016.757
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang F, Hu W, Zhang B, Xu J, Shui Y, Zhou X, Ren X, Chen X, Shen L, Wei Q, Wei Q, et al: Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma. Biomed Rep 5: 437-442, 2016.
APA
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X. ... Wei, Q. (2016). Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma. Biomedical Reports, 5, 437-442. https://doi.org/10.3892/br.2016.757
MLA
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X., Ren, X., Chen, X., Shen, L., Wei, Q."Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma". Biomedical Reports 5.4 (2016): 437-442.
Chicago
Jiang, F., Hu, W., Zhang, B., Xu, J., Shui, Y., Zhou, X., Ren, X., Chen, X., Shen, L., Wei, Q."Changes in c-Kit expression levels during the course of radiation therapy for nasopharyngeal carcinoma". Biomedical Reports 5, no. 4 (2016): 437-442. https://doi.org/10.3892/br.2016.757
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