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Article

CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence

  • Authors:
    • Mariella De Ameida Melo
    • Rodrigo José De Vasconcelos‑Valença
    • Fidelis Manes Neto
    • Rafael Soares Borges
    • Danylo Rafhael Costa‑Silva
    • Maria Da Conceição Barros‑Oliveira
    • Umbelina Soares Borges
    • Airlane Pereira Alencar
    • Vladimir Costa Silva
    • Benedito Borges Da Silva
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Federal University of Piauí, Health Sciences Center, Teresina, PI 64001‑020, Brazil, Department of Oncology, São Marcos Hospital, Teresina, PI 64001‑280, Brazil, Department of Mastology, Getulio Vargas Hospital, Federal University of Piauí, Teresina, PI 64001‑020, Brazil, Department of Statistics, State University of São Paulo, São Paulo, SP 05508‑900, Brazil, Department of Molecular Biology, Natan Portella Hospital, Federal University of Piaui, Teresina, PI 64001‑450, Brazil
  • Pages: 574-578
    |
    Published online on: October 4, 2016
       https://doi.org/10.3892/br.2016.771
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Abstract

At present, there is controversy regarding the efficacy of tamoxifen in breast cancer patients who are carriers of cytochrome P450 2D6 (CYP2D6) gene polymorphisms, in terms of recurrence and overall survival. Thus, the aim of the present study was to investigate the association of the CYP2D6 *4, *10 and *17 gene polymorphisms with breast cancer recurrence in a Brazilian population. The cohort comprised 40 receptor‑positive breast cancer patients without recurrence and 40 with distant recurrence. A 3‑ml sample of peripheral blood was collected from each patient to determine the presence of the *4, *10 and *17 single nucleotide polymorphisms of the CYP2D6 gene by quantitative polymerase chain reaction analysis. There was no statistically significant difference between the two groups regarding the polymorphism frequency (P=0.246). The results revealed that intermediate metabolizers occurred in 5% of patients without recurrence and in 15% of those with distant recurrence. Poor metabolizers occurred in only 1 patient (2.5%) per group, and there was no significant difference between the groups (P=0.789). The present study concluded that the CYP2D6 gene polymorphism in women with hormone‑sensitive breast cancer treated with tamoxifen was not associated with disease recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Melo MD, De Vasconcelos‑Valença RJ, Neto FM, Borges RS, Costa‑Silva DR, Barros‑Oliveira MD, Borges US, Alencar AP, Silva VC, Da Silva BB, Da Silva BB, et al: CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence. Biomed Rep 5: 574-578, 2016.
APA
Melo, M.D., De Vasconcelos‑Valença, R.J., Neto, F.M., Borges, R.S., Costa‑Silva, D.R., Barros‑Oliveira, M.D. ... Da Silva, B.B. (2016). CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence. Biomedical Reports, 5, 574-578. https://doi.org/10.3892/br.2016.771
MLA
Melo, M. D., De Vasconcelos‑Valença, R. J., Neto, F. M., Borges, R. S., Costa‑Silva, D. R., Barros‑Oliveira, M. D., Borges, U. S., Alencar, A. P., Silva, V. C., Da Silva, B. B."CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence". Biomedical Reports 5.5 (2016): 574-578.
Chicago
Melo, M. D., De Vasconcelos‑Valença, R. J., Neto, F. M., Borges, R. S., Costa‑Silva, D. R., Barros‑Oliveira, M. D., Borges, U. S., Alencar, A. P., Silva, V. C., Da Silva, B. B."CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence". Biomedical Reports 5, no. 5 (2016): 574-578. https://doi.org/10.3892/br.2016.771
Copy and paste a formatted citation
x
Spandidos Publications style
Melo MD, De Vasconcelos‑Valença RJ, Neto FM, Borges RS, Costa‑Silva DR, Barros‑Oliveira MD, Borges US, Alencar AP, Silva VC, Da Silva BB, Da Silva BB, et al: CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence. Biomed Rep 5: 574-578, 2016.
APA
Melo, M.D., De Vasconcelos‑Valença, R.J., Neto, F.M., Borges, R.S., Costa‑Silva, D.R., Barros‑Oliveira, M.D. ... Da Silva, B.B. (2016). CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence. Biomedical Reports, 5, 574-578. https://doi.org/10.3892/br.2016.771
MLA
Melo, M. D., De Vasconcelos‑Valença, R. J., Neto, F. M., Borges, R. S., Costa‑Silva, D. R., Barros‑Oliveira, M. D., Borges, U. S., Alencar, A. P., Silva, V. C., Da Silva, B. B."CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence". Biomedical Reports 5.5 (2016): 574-578.
Chicago
Melo, M. D., De Vasconcelos‑Valença, R. J., Neto, F. M., Borges, R. S., Costa‑Silva, D. R., Barros‑Oliveira, M. D., Borges, U. S., Alencar, A. P., Silva, V. C., Da Silva, B. B."CYP2D6 gene polymorphisms in Brazilian patients with breast cancer treated with adjuvant tamoxifen and its association with disease recurrence". Biomedical Reports 5, no. 5 (2016): 574-578. https://doi.org/10.3892/br.2016.771
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