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Review

Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review)

  • Authors:
    • Samuel N. Uwaezuoke
    • Henrietta U. Okafor
    • Vivian N. Muoneke
    • Odutola I. Odetunde
    • Chioma L. Odimegwu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, College of Medicine, University of Nigeria Teaching Hospital, Ituku‑Ozalla, Enugu 400001, Nigeria, Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku‑Ozalla, Enugu 400001, Nigeria
  • Pages: 660-664
    |
    Published online on: October 18, 2016
       https://doi.org/10.3892/br.2016.781
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Abstract

Global differences in the observed causes of chronic kidney disease (CKD) in children are well documented and are attributed to dissimilarities in clime, race, hereditary, and ancestry. Thus, familial clustering and disparities in CKD prevalence rates across ethnic and racial groups indicate that the progression of renal disease has a strong genetic component. Mammalian studies have demonstrated a feasible nexus between nutrition and non‑genetic exposure (around the time of conception and in epigenetic changes) in the expression of major genes identified in renal organogenesis. The major consequence is a reduction in the number of nephrons, with subsequent predisposition to hypertension and CKD. Identifying these epigenetic changes is crucial (due to their potentially reversible nature), as they may serve as future therapeutic targets to prevent kidney fibrosis and CKD. Despite progress in the field of epigenetics in oncology, research in other subspecialties of medicine is largely experimental with few existing studies regarding the clinical implication of epigenetics in renal disease. Therapeutic trajectories for CKD in children based on the influence of epigenetics may eventually revolutionize the management of this disease. The aim of the current narrative review is to appraise the role of epigenetics in CKD, and highlight the potential future therapeutic pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Uwaezuoke SN, Okafor HU, Muoneke VN, Odetunde OI and Odimegwu CL: Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review). Biomed Rep 5: 660-664, 2016.
APA
Uwaezuoke, S.N., Okafor, H.U., Muoneke, V.N., Odetunde, O.I., & Odimegwu, C.L. (2016). Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review). Biomedical Reports, 5, 660-664. https://doi.org/10.3892/br.2016.781
MLA
Uwaezuoke, S. N., Okafor, H. U., Muoneke, V. N., Odetunde, O. I., Odimegwu, C. L."Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review)". Biomedical Reports 5.6 (2016): 660-664.
Chicago
Uwaezuoke, S. N., Okafor, H. U., Muoneke, V. N., Odetunde, O. I., Odimegwu, C. L."Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review)". Biomedical Reports 5, no. 6 (2016): 660-664. https://doi.org/10.3892/br.2016.781
Copy and paste a formatted citation
x
Spandidos Publications style
Uwaezuoke SN, Okafor HU, Muoneke VN, Odetunde OI and Odimegwu CL: Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review). Biomed Rep 5: 660-664, 2016.
APA
Uwaezuoke, S.N., Okafor, H.U., Muoneke, V.N., Odetunde, O.I., & Odimegwu, C.L. (2016). Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review). Biomedical Reports, 5, 660-664. https://doi.org/10.3892/br.2016.781
MLA
Uwaezuoke, S. N., Okafor, H. U., Muoneke, V. N., Odetunde, O. I., Odimegwu, C. L."Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review)". Biomedical Reports 5.6 (2016): 660-664.
Chicago
Uwaezuoke, S. N., Okafor, H. U., Muoneke, V. N., Odetunde, O. I., Odimegwu, C. L."Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories (Review)". Biomedical Reports 5, no. 6 (2016): 660-664. https://doi.org/10.3892/br.2016.781
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