A case study of bofutsushosan‑induced pulmonary injury in a patient: Case report

Miyazaki,Kunihiko; Satoh,Hiroaki; Watanabe,Hiroko; Shiozawa,Toshihiro; Tamura,Tomohiro; Kawaguchi,Mio; Hizawa,Nobuyuki

doi:10.3892/br.2016.787

December-2016 Volume 5 Issue 6

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December-2016 Volume 5 Issue 6

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Case Report

A case study of bofutsushosan‑induced pulmonary injury in a patient: Case report

Authors:
- Kunihiko Miyazaki
- Hiroaki Satoh
- Hiroko Watanabe
- Toshihiro Shiozawa
- Tomohiro Tamura
- Mio Kawaguchi
- Nobuyuki Hizawa
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Ryugasaki Saiseikai General Hospital, Ryugasaki, Ibaraki 301‑0854, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito Kyodo General Hospital, Mito, Ibaraki 310‑0015, Japan, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305‑8575, Japan
Pages: 758-760
|
Published online on: October 19, 2016

https://doi.org/10.3892/br.2016.787
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Abstract

Bofutsushosan, a herbal (traditional Kampo) medicine, is administered to obese patients in North‑East Asia. Bofutsushosan has been reported to exert various anti‑obesity effects by stimulating the adipose tissue. The present study describes the case of a patient who developed a severe pulmonary injury that was potentially associated with bofutsushosan therapy. A 52‑year‑old woman was admitted to Mito Medical Center, University of Tsukuba, Mito Kyodo General Hospital (Mito, Japan) due to progressive dyspnea. Two months previously, bofutsushosan had been newly prescribed for her obesity. Bilateral ground‑glass opacities and progressive respiratory deterioration suggested respiratory failure due to a therapeutic agent‑induced lung injury. With discontinuation of bofutsushosan and the administration of a corticosteroid, an improvement in her respiratory condition was achieved, although sequelae remained in certain areas of the lungs. Resumption of other therapeutic agents did not reinduce the lung injury. Therefore, a diagnosis of bofutsushosan‑induced lung injury was made. Although bofutsushosan‑induced lung injury is particularly rare, clinicians should consider it when bofutsushosan is used.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A case study of bofutsushosan‑induced pulmonary injury in a patient: Case report

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