Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
December-2016 Volume 5 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 5 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression

  • Authors:
    • Guangdong Chen
    • Haiman Bian
    • Deguo Jiang
    • Mingwei Cui
    • Shengzhang Ji
    • Mei Liu
    • Xu Lang
    • Chuanjun Zhuo
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, Wenzhou 7th People's Hospital, Wenzhou, Zhejiang 325000, P.R. China, Department of Radiology, Tianjin 4th Centre Hospital, Tianjin 300143, P.R. China, Department of Psychiatry, Tianjin Anning Hospital, Tianjin 300300, P.R. China, Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin 300222, P.R. China, Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 675-680
    |
    Published online on: October 31, 2016
       https://doi.org/10.3892/br.2016.796
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Many previous studies have reported that regional cerebral blood flow (rCBF) aberrations may be one of the pathological characteristics of depression and rCBF has demonstrated a certain degree of asymmetry. However, studies investigating the cerebral blood perfusion asymmetry changes of drug‑naïve patients experiencing their first episode of major depression using pseudo‑continuous arterial spin labeling (pCASL) are rare. Ten drug‑naïve patients experiencing their first major depression episode and 15 healthy volunteers were enrolled in the current study. A novel pCASL method was applied to whole brain MRI scans of all of the samples. The Statistics Parameter Mapping and Relative Expression Software Tool software packages were used for the pre‑processing and statistical analysis of the two sets of images, and the differences in the cerebral blood perfusion at the whole brain level were compared between the two groups. Compared with the healthy control group, the cerebral perfusion of the depression patients showed an asymmetric pattern. Decreased cerebral blood perfusion regions were primarily located in the left hemisphere, specifically in the left temporal lobe, frontal lobe and cingulate cortex [P<0.05 and cluster size ≥30 with false discovery rate (FDR) correction]. Simultaneously, increased perfusion regions were predominantly located in the right hemisphere, specifically in the right cerebellum, thalamus, frontal lobe and anterior cingulate cortex (P<0.05 and cluster size ≥30, with FDR correction). Thus, pCASL may characterize the alterations in cerebral blood perfusion of patients with depression.
View Figures

Figure 1

Figure 2

View References

1 

Saltiel PF and Silvershein DI: Major depressive disorder: Mechanism-based prescribing for personalized medicine. Neuropsychiatr Dis Treat. 11:875–888. 2015.PubMed/NCBI

2 

Drevets WC: Neuroimaging studies of mood disorders. Biol Psychiatry. 48:813–829. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, et al: Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression. J Am Acad Child Adolesc Psychiatry. 52:1076–1091.e2. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Wang DJ, Chen Y, Fernández-Seara MA and Detre JA: Potentials and challenges for arterial spin labeling in pharmacological magnetic resonance imaging. J Pharmacol Exp Ther. 337:359–366. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hartkamp NS, Petersen ET, De Vis JB, Bokkers RP and Hendrikse J: Mapping of cerebral perfusion territories using territorial arterial spin labeling: Techniques and clinical application. NMR Biomed. 26:901–912. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Järnum H, Eskildsen SF, Steffensen EG, Lundbye-Christensen S, Simonsen CW, Thomsen IS, Fründ ET, Théberge J and Larsson EM: Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Acta Psychiatr Scand. 124:435–446. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Ota M, Noda T, Sato N, Hattori K, Teraishi T, Hori H, Nagashima A, Shimoji K, Higuchi T and Kunugi H: Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: A pseudo-continuous arterial spin labeling (pCASL) study. J Affect Disord. 165:59–63. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Nobler MS, Olvet KR and Sackeim HA: Effects of medications on cerebral blood flow in late-life depression. Curr Psychiatry Rep. 4:51–58. 2002. View Article : Google Scholar : PubMed/NCBI

9 

First MB, Spitzer RL, Gibbon M and Williams JB: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID)Biometrics Research. New York State Psychiatric Institute; New York, NY: 1996

10 

Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry. 23:56–62. 1960. View Article : Google Scholar : PubMed/NCBI

11 

Alexopoulos GS, Kiosses DN, Heo M, Murphy CF, Shanmugham B and Gunning-Dixon F: Executive dysfunction and the course of geriatric depression. Biol Psychiatry. 58:204–210. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Davies J, Lloyd KR, Jones IK, Barnes A and Pilowsky LS: Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression. Am J Psychiatry. 160:374–376. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Galynker II, Cai J, Ongseng F, Finestone H, Dutta E and Serseni D: Hypofrontality and negative symptoms in major depressive disorder. J Nucl Med. 39:608–612. 1998.PubMed/NCBI

14 

Wang Y, Zhang H, Tang S, Liu X, O'Neil A, Turner A, Chai F, Chen F and Berk M: Assessing regional cerebral blood flow in depression using 320-slice computed tomography. PLoS One. 9:e1077352014. View Article : Google Scholar : PubMed/NCBI

15 

Blackhart GC, Minnix JA and Kline JP: Can EEG asymmetry patterns predict future development of anxiety and depression? A preliminary study. Biol Psychol. 72:46–50. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Bruder GE, Quitkin FM, Stewart JW, Martin C, Voglmaier MM and Harrison WM: Cerebral laterality and depression: Differences in perceptual asymmetry among diagnostic subtypes. J Abnorm Psychol. 98:177–186. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Hannesdóttir DK, Doxie J, Bell MA, Ollendick TH and Wolfe CD: A longitudinal study of emotion regulation and anxiety in middle childhood: Associations with frontal EEG asymmetry in early childhood. Dev Psychobiol. 52:197–204. 2010.PubMed/NCBI

18 

Kemp AH, Cooper NJ, Hermens G, Gordon E, Bryant R and Williams LM: Toward an integrated profile of emotional intelligence: Introducing a brief measure. J Integr Neurosci. 4:41–61. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Liu H, Yin HF, Wu DX and Xu SJ: Event-related potentials in response to emotional words in patients with major depressive disorder and healthy controls. Neuropsychobiology. 70:36–43. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Quraan MA, Protzner AB, Daskalakis ZJ, Giacobbe P, Tang CW, Kennedy SH, Lozano AM and McAndrews MP: EEG power asymmetry and functional connectivity as a marker of treatment effectiveness in DBS surgery for depression. Neuropsychopharmacology. 39:1270–1281. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Sundermann B, Olde Lütke Beverborg M and Pfleiderer B: Toward literature-based feature selection for diagnostic classification: A meta-analysis of resting-state fMRI in depression. Front Hum Neurosci. 8:6922014. View Article : Google Scholar : PubMed/NCBI

22 

Moretti DV, Prestia A, Binetti G, Zanetti O and Frisoni GB: Increase of theta frequency is associated with reduction in regional cerebral blood flow only in subjects with mild cognitive impairment with higher upper alpha/low alpha EEG frequency power ratio. Front Behav Neurosci. 7:1882013. View Article : Google Scholar : PubMed/NCBI

23 

Lui S, Parkes LM, Huang X, Zou K, Chan RC, Yang H, Zou L, Li D, Tang H, Zhang T, et al: Depressive disorders: Focally altered cerebral perfusion measured with arterial spin-labeling MR imaging. Radiology. 251:476–484. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Smith DJ and Cavanagh JT: The use of single photon emission computed tomography in depressive disorders. Nucl Med Commun. 26:197–203. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Vasic N, Wolf ND, Grön G, Sosic-Vasic Z, Connemann BJ, Sambataro F, von Strombeck A, Lang D, Otte S, Dudek M, et al: Baseline brain perfusion and brain structure in patients with major depression: A multimodal magnetic resonance imaging study. J Psychiatry Neurosci. 40:412–421. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Patrick KS, Corbin TR and Murphy CE: Ethylphenidate as a selective dopaminergic agonist and methylphenidate-ethanol transesterification biomarker. J Pharm Sci. 103:3834–3842. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen G, Bian H, Jiang D, Cui M, Ji S, Liu M, Lang X and Zhuo C: Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression. Biomed Rep 5: 675-680, 2016.
APA
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M. ... Zhuo, C. (2016). Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression. Biomedical Reports, 5, 675-680. https://doi.org/10.3892/br.2016.796
MLA
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M., Lang, X., Zhuo, C."Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression". Biomedical Reports 5.6 (2016): 675-680.
Chicago
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M., Lang, X., Zhuo, C."Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression". Biomedical Reports 5, no. 6 (2016): 675-680. https://doi.org/10.3892/br.2016.796
Copy and paste a formatted citation
x
Spandidos Publications style
Chen G, Bian H, Jiang D, Cui M, Ji S, Liu M, Lang X and Zhuo C: Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression. Biomed Rep 5: 675-680, 2016.
APA
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M. ... Zhuo, C. (2016). Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression. Biomedical Reports, 5, 675-680. https://doi.org/10.3892/br.2016.796
MLA
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M., Lang, X., Zhuo, C."Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression". Biomedical Reports 5.6 (2016): 675-680.
Chicago
Chen, G., Bian, H., Jiang, D., Cui, M., Ji, S., Liu, M., Lang, X., Zhuo, C."Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression". Biomedical Reports 5, no. 6 (2016): 675-680. https://doi.org/10.3892/br.2016.796
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team