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Article Open Access

Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma

  • Authors:
    • Lixin Sun
    • Weilin Xue
    • Jun Li
    • Zhaoshan Zhou
    • Wei Han
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Respiratory Medicine, Qingdao Haici Hospital, Qingdao, Shandong 266033, P.R. China, Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 21-26
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/br.2016.803
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Abstract

Single nucleotide polymorphisms (SNPs) in the interleukin‑4 receptor (IL‑4R) gene have been identified as having a close association with asthma severity in different populations. In our previous studies, a close association between asthma and a distinctive palm dermatoglyphic pattern was observed; however, the clinical implication and underlying genetic mechanisms of this particular palm pattern have not been clarified. Whether this particular palm pattern is associated with asthma severity and IL‑4R SNPs was assessed in the present study. A case cohort study was conducted in 400 patients with allergic asthma and in 200 healthy controls. DNA was extracted from peripheral blood leukocytes for analysis of 11 IL‑4R SNPs associated with asthma via polymerase chain reaction. There are two SNPs, rs1805012 and rs3024608, which are associated with asthma (rs1805012, dominant model; P=0.03 and rs3024608, codominant model; P=0.029), and two SNPs, rs1805010 and rs3024608, which are associated with the positive palm pattern (rs1805010, log‑additive model; P=0.031 and rs3024608, codominant model; P=0.016). The SNP of rs3024608 is associated with asthma and the positive palm pattern. Thus, genetic variation in IL‑4R may be associated with the development of asthma and the distinctive palm pattern; however, further investigations are required to identify the connection between asthma and palm dermatoglyphic patterns.
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Copy and paste a formatted citation
Spandidos Publications style
Sun L, Xue W, Li J, Zhou Z and Han W: Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma. Biomed Rep 6: 21-26, 2017.
APA
Sun, L., Xue, W., Li, J., Zhou, Z., & Han, W. (2017). Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma. Biomedical Reports, 6, 21-26. https://doi.org/10.3892/br.2016.803
MLA
Sun, L., Xue, W., Li, J., Zhou, Z., Han, W."Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma". Biomedical Reports 6.1 (2017): 21-26.
Chicago
Sun, L., Xue, W., Li, J., Zhou, Z., Han, W."Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma". Biomedical Reports 6, no. 1 (2017): 21-26. https://doi.org/10.3892/br.2016.803
Copy and paste a formatted citation
x
Spandidos Publications style
Sun L, Xue W, Li J, Zhou Z and Han W: Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma. Biomed Rep 6: 21-26, 2017.
APA
Sun, L., Xue, W., Li, J., Zhou, Z., & Han, W. (2017). Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma. Biomedical Reports, 6, 21-26. https://doi.org/10.3892/br.2016.803
MLA
Sun, L., Xue, W., Li, J., Zhou, Z., Han, W."Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma". Biomedical Reports 6.1 (2017): 21-26.
Chicago
Sun, L., Xue, W., Li, J., Zhou, Z., Han, W."Palm dermatoglyphs and interleukin‑4 receptor polymorphisms in asthma". Biomedical Reports 6, no. 1 (2017): 21-26. https://doi.org/10.3892/br.2016.803
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