Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia

  • Authors:
    • Daisuke Asaoka
    • Akihito Nagahara
    • Mariko Hojo
    • Kenshi Matsumoto
    • Hiroya Ueyama
    • Kohei Matsumoto
    • Kentaro Izumi
    • Tsutomu Takeda
    • Hiroyuki Komori
    • Yoichi Akazawa
    • Yuji Shimada
    • Taro Osada
    • Sumio Watanabe
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, University of Juntendo, School of Medicine, Tokyo 113‑8421, Japan, Department of Gastroenterology, Juntendo University Shizuoka Hospital, Shizuoka 410‑2295, Japan
    Copyright: © Asaoka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 175-180
    |
    Published online on: December 15, 2016
       https://doi.org/10.3892/br.2016.828
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the efficacy of a potassium‑competitive acid blocker (PCAB) named vonoprazan (VPZ) for improving symptoms in patients with reflux esophagitis (RE), non‑erosive reflux disease (NERD), and functional dyspepsia (FD). A hospital‑based, retrospective study of outpatients in our department (Department of Gastroenterology, University of Juntendo, Tokyo, Japan) between March 2015 and August 2016 was performed. The patients who were experiencing heartburn, acid regurgitation, gastric pain, and/or a heavy feeling in the stomach of at least moderate severity at baseline were treated with 20 mg VPZ once daily for 4 weeks. The patients completed the global overall symptom (GOS) scale to determine their symptom severity at baseline and after the 4 week treatment period. The proportions of patients with RE, NERD, and FD achieving improvement of their symptoms, defined as a GOS scale score of 1 (‘no problem’) or 2 (‘minimal problem’), were evaluated. During 4 weeks of VPZ therapy, changes in the gastroesophageal reflux disease (GERD) score, which was defined as the total points for heartburn and acid regurgitation on the GOS scale in patients with RE and NERD, and in the FD score, which was defined as the total points for gastric pain and a heavy feeling in the stomach on the GOS scale in patients with FD, were also evaluated. A total of 88 eligible cases were included in the present study, comprising 20 patients with RE, 25 patients with NERD, and 43 patients with FD. The rates of symptomatic improvement in patients with RE, NERD, and FD were 75.0, 60.0, and 48.8%, respectively. For the patients who were first administered VPZ, the rates of symptomatic improvement were 90.9, 66.7, and 58.8% in patients with RE, NERD, and FD, respectively. For those patients who were resistant to 8 weeks of proton pump inhibitor therapy, the rates of symptomatic improvement were 55.6, 53.8, and 42.3% in patients with RE, NERD, and FD, respectively. The GERD score in patients with RE and NERD, and the FD score in FD patients, were decreased after 4 weeks of VPZ therapy (P<0.01). In patients with RE, NERD and FD, the possibility that PCAB may be used as a novel therapeutic drug was suggested. However, the number of study subjects was small; therefore, further, larger and prospective studies are required.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Fujiwara Y and Arakawa T: Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 44:518–534. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Dimenas E: Methodological aspects of evaluation of quality of life in upper gastrointestinal diseases. Scand J Gastroenterol Suppl. 199:181993. View Article : Google Scholar : PubMed/NCBI

3 

Meineche-Schmidt V, Talley NJ, Pap A, Kordecki H, Schmid V, Ohlsson L, Wahlqvist P, Wiklund I and Bolling-Sternevald E: Impact of functional dyspepsia on quality of life and health care consumption after cessation of antisecretory treatment. A multicentre 3-month follow-up study. Scand J Gastroenterol. 34:566–574. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Chiba N, De Gara CJ, Wilkinson JM and Hunt RH: Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: A meta-analysis. Gastroenterology. 112:1798–1810. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Talley NJ, Meineche-Schmidt V, Paré P, Duckworth M, Räisänen P, Pap A, Kordecki H and Schmid V: Efficacy of omeprazole in functional dyspepsia: Double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther. 12:1055–1065. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Chey WD, Mody RR and Izat E: Patient and physician satisfaction with proton pump inhibitors (PPIs): Are there opportunities for improvement? Dig Dis Sci. 55:3415–3422. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Hori Y, Imanishi A, Matsukawa J, et al: 1- [5- (2- Fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl]- N- methylmethanamine monofumarate (TAK- 438), a novel and potent potassium- competitive acid blocker for the treatment of acid- related diseases. J Pharmacol Exp Ther. 335:231–238. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Ashida K, Sakurai Y, Nishimura A, Kudou K, Hiramatsu N, Umegaki E, Iwakiri K and Chiba T: Randomised clinical trial: A dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis. Aliment Pharmacol Ther. 42:685–695. 2015. View Article : Google Scholar : PubMed/NCBI

9 

van Zanten SJ Veldhuyzen, Chiba N, Armstrong D, Barkun AN, Thomson AB, Mann V, Escobedo S, Chakraborty B and Nevin K: Validation of a 7-point global overall symptom scale to measure the severity of dyspepsia symptoms in clinical trials. Aliment Pharmacol Ther. 23:521–529. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Sakurai K, Nagahara A, Inoue K, Akiyama J, Mabe K, Suzuki J, Habu Y, Araki A, Suzuki T, Satoh K, et al: Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS). BMC Gastroenterol. 12:422012. View Article : Google Scholar : PubMed/NCBI

11 

van Zanten SV, Armstrong D, Chiba N, Flook N, White RJ, Chakraborty B and Gasco A: Esomeprazole 40 mg once a day in patients with functional dyspepsia: The randomized, placebo-controlled ‘ENTER’ trial. Am J Gastroenterol. 101:2096–2106. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Savarino V, Vigneri S and Celle G: The 13C urea breath test in the diagnosis of Helicobacter pylori infection. Gut. 45:(Suppl 1). I18–I22. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Kimura K and Takemoto T: An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 3:87–97. 1969. View Article : Google Scholar

14 

Armstrong D, Bennett JR, Blum AL, Dent J, De Dombal FT, Galmiche JP, Lundell L, Margulies M, Richter JE, Spechler SJ, et al: The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology. 111:85–92. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Soga T, Matsuura M, Kodama Y, Fujita T, Sekimoto I, Nishimura K, Yoshida S, Kutsumi H and Fujimoto S: Is a proton pump inhibitor necessary for the treatment of lower-grade reflux esophagitis? J Gastroenterol. 34:435–440. 1999. View Article : Google Scholar : PubMed/NCBI

16 

El-Serag H, Becher A and Jones R: Systematic review: Persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 32:720–737. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Fennerty MB and Johnson DA: Heartburn severity does not predict disease severity in patients with erosive esophagitis. MedGenMed. 8:62006.PubMed/NCBI

18 

Pace F, Negrini C, Wiklund I, Rossi C and Savarino V: ITALIAN ONE INVESTIGATORS STUDY GROUP: Quality of life in acute and maintenance treatment of non-erosive and mild erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 22:349–356. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Nagahara A, Suzuki T, Nagata N, Sugai N, Takeuchi Y, Sakurai K, Miyamoto M, Inoue K, Akiyama J, Mabe K, et al: A multicentre randomised trial to compare the efficacy of omeprazole versus rabeprazole in early symptom relief in patients with reflux esophagitis. J Gastroenterol. 49:1536–1547. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Fass R: Erosive esophagitis and nonerosive reflux disease (NERD): Comparison of epidemiologic, physiologic, and therapeutic characteristics. J Clin Gastroenterol. 41:131–137. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Nagahara A, Miwa H, Minoo T, Hojo M, Kawabe M, Osada T, Kurosawa A, Asaoka D, Terai T, Ohkusa T, et al: Increased esophageal sensitivity to acid and saline in patients with nonerosive gastro-esophageal reflux disease. J Clin Gastroenterol. 40:891–895. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Adachi K, Katsube T, Kawamura A, Takashima T, Yuki M, Amano K, Ishihara S, Fukuda R, Watanabe M and Kinoshita Y: CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole. Aliment Pharmacol Ther. 14:1259–1266. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O and Sachs G: Characterization of a novel potassium-competitive acid blocker of the gastric H, K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438). J Pharmacol Exp Ther. 339:412–420. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M and Inatomi N: A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther. 337:797–804. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Tack J, Piessevaux H, Coulie B, Caenepeel P and Janssens J: Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology. 115:1346–1352. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Talley NJ, Tack J, Ptak T, Gupta R and Giguère M: Itopride in functional dyspepsia: Results of two phase III multicentre, randomised, double-blind, placebo-controlled trials. Gut. 57:740–746. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Iwakiri R, Tominaga K, Furuta K, Inamori M, Furuta T, Masuyama H, Kanke K, Nagahara A, Haruma K, Kinoshita Y, et al: Randomised clinical trial: Rabeprazole improves symptoms in patients with functional dyspepsia in Japan. Aliment Pharmacol Ther. 38:729–740. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Matsueda K, Hongo M, Tack J, Saito Y and Kato H: A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut. 61:821–828. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 130:1377–1390. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Asaoka D, Nagahara A, Hojo M, Matsumoto K, Ueyama H, Matsumoto K, Izumi K, Takeda T, Komori H, Akazawa Y, Akazawa Y, et al: Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia. Biomed Rep 6: 175-180, 2017.
APA
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K. ... Watanabe, S. (2017). Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia. Biomedical Reports, 6, 175-180. https://doi.org/10.3892/br.2016.828
MLA
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K., Izumi, K., Takeda, T., Komori, H., Akazawa, Y., Shimada, Y., Osada, T., Watanabe, S."Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia". Biomedical Reports 6.2 (2017): 175-180.
Chicago
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K., Izumi, K., Takeda, T., Komori, H., Akazawa, Y., Shimada, Y., Osada, T., Watanabe, S."Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia". Biomedical Reports 6, no. 2 (2017): 175-180. https://doi.org/10.3892/br.2016.828
Copy and paste a formatted citation
x
Spandidos Publications style
Asaoka D, Nagahara A, Hojo M, Matsumoto K, Ueyama H, Matsumoto K, Izumi K, Takeda T, Komori H, Akazawa Y, Akazawa Y, et al: Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia. Biomed Rep 6: 175-180, 2017.
APA
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K. ... Watanabe, S. (2017). Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia. Biomedical Reports, 6, 175-180. https://doi.org/10.3892/br.2016.828
MLA
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K., Izumi, K., Takeda, T., Komori, H., Akazawa, Y., Shimada, Y., Osada, T., Watanabe, S."Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia". Biomedical Reports 6.2 (2017): 175-180.
Chicago
Asaoka, D., Nagahara, A., Hojo, M., Matsumoto, K., Ueyama, H., Matsumoto, K., Izumi, K., Takeda, T., Komori, H., Akazawa, Y., Shimada, Y., Osada, T., Watanabe, S."Efficacy of a potassium‑competitive acid blocker for improving symptoms in patients with reflux esophagitis, non‑erosive reflux disease, and functional dyspepsia". Biomedical Reports 6, no. 2 (2017): 175-180. https://doi.org/10.3892/br.2016.828
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team