Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Biomedical Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9434 Online ISSN: 2049-9442
Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 6 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis

  • Authors:
    • Saeedeh Salimi
    • Mahnaz Shahrakipour
    • Azam Hajizadeh
    • Mojgan Mokhtari
    • Mahdieh Mousavi
    • Batool Teimoori
    • Minoo Yaghmaei
  • View Affiliations / Copyright

    Affiliations: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 9816743175, Iran, Department of Biostatistics and Epidemiology, School of Public Health, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 9816743175, Iran, Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 9816743175, Iran, Department of Biology, Faculty of Science, University of Zabol, Zabol, Sistan and Baluchestan 9861335856, Iran, Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshty University of Medical Sciences, Tehran 1985717413, Iran
  • Pages: 237-241
    |
    Published online on: December 21, 2016
       https://doi.org/10.3892/br.2016.830
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Uterine leiomyoma (UL) is the most common benign tumor causing considerable morbidity during the reproductive years in women. Cyclin D1 (CCND1) is a cell cycle regulatory protein that is required for the G1 phase, and increased expression levels of this protein may affect tumorigenesis. The present study aimed to assess the possible effect of the CCND1 G870A polymorphism on UL susceptibility. A total of 154 women with UL and 197 healthy women who were age‑, body mass index (BMI)‑ and ethnicity‑matched were genotyped for the CCND1 G870A (rs9344) polymorphism using the polymerase chain reaction‑restriction fragment length polymorphism method. The effects of G870A transition on the structure of mRNA and proteins of CCND1 was evaluated using bioinformatics tools. The frequency of the CCND1 870AA genotype was significantly higher in women with UL compared with the control subjects, and the risk of UL was 1.4‑fold higher in women with the AA genotype when compared with the GG genotype before and after adjusting for age, BMI, and ethnicity [odds ratio (OR), 1.4; 95% confidence interval (CI), 1.1‑2 (P=0.02)]. The frequency of CCND1 870GA genotype was not significantly different between the two groups. The frequency of the CCND1 870A allele was significantly higher in the women with UL when compared with the control subjects (57 vs. 48%; P=0.02). The in silico analysis revealed that the G870A transition may fundamentally alter the structure of the CCND1‑mRNA. Thus, the CCND1 870AA genotype was associated with UL susceptibility in a sample of women from the southeast of Iran.
View Figures

Figure 1

View References

1 

Stewart EA, Friedman AJ, Peck K and Nowak RA: Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle. J Clin Endocrinol Metab. 79:900–906. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Barbarisi A, Petillo O, Di Lieto A, Melone MA, Margarucci S, Cannas M and Peluso G: 17-beta estradiol elicits an autocrine leiomyoma cell proliferation: Evidence for a stimulation of protein kinase-dependent pathway. J Cell Physiol. 186:414–424. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Jeon YT, Kim JW, Park NH, Song YS, Kang SB and Lee HP: DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma. Hum Reprod. 20:1586–1589. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Gittenberger-de Groot AC, DeRuiter MC, Bergwerff M and Poelmann RE: Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 19:1589–1594. 1999. View Article : Google Scholar

5 

Medikare V, Kandukuri LR, Ananthapur V, Deenadayal M and Nallari P: The genetic bases of uterine fibroids; a review. J Reprod Infertil. 12:181–191. 2011.PubMed/NCBI

6 

Vikhlyaeva EM, Khodzhaeva ZS and Fantschenko ND: Familial predisposition to uterine leiomyomas. Int J Gynaecol Obstet. 51:127–131. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Galderisi U, Jori FP and Giordano A: Cell cycle regulation and neural differentiation. Oncogene. 22:5208–5219. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Sherr CJ: Cancer cell cycles. Science. 274:1672–1677. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Shevra CR, Ghosh A and Kumar M: Cyclin D1 and Ki-67 expression in normal, hyperplastic and neoplastic endometrium. J Postgrad Med. 61:15–20. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Bae DS, Cho SB, Kim YJ, Whang JD, Song SY, Park CS, Kim DS and Lee JH: Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus. Gynecol Oncol. 81:341–347. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Ayed A and Adesina A: Prognostic significance of cyclin D1 expression in resected stage I, II non-small cell lung cancer in Arabs. Interact Cardiovasc Thorac Surg. 5:47–51. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Abramson VG, Troxel AB, Feldman M, Mies C, Wang Y, Sherman L, McNally S, Diehl A and Demichele A: Cyclin D1b in human breast carcinoma and coexpression with cyclin D1a is associated with poor outcome. Anticancer Res. 30:1279–1285. 2010.PubMed/NCBI

13 

Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD and Heighway J: Alternate splicing produces a novel cyclin D1 transcript. Oncogene. 11:1005–1011. 1995.PubMed/NCBI

14 

Han SS, No JH, Jeon YT, Kim JW, Park NH, Song YS, Kang SB and Lee HP: Association of cyclin D1 G870A polymorphism with uterine leiomyoma in women whose body mass index values are above 25 kg/m2. Hum Reprod. 23:525–529. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Sabarinathan R, Tafer H, Seemann SE, Hofacker IL, Stadler PF and Gorodkin J: The RNAsnp web server: Predicting SNP effects on local RNA secondary structure. Nucleic Acids Res. 41:W475–W479. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Mallya SM and Arnold A: Cyclin D1 in parathyroid disease. Front Biosci. 5:D367–D371. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Catalano S, Giordano C, Rizza P, Gu G, Barone I, Bonofiglio D, Giordano F, Malivindi R, Gaccione D, Lanzino M, et al: Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. J Cell Physiol. 218:490–500. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Li HY, Xu Q, Zhu T, Zhou JH, Deng DR, Wang SX, Lu YP and Ma D: Expression and clinical significance of Pin1 and Cyclin D1 in cervical cancer cell lines and cervical epithelial tissues. Ai Zheng. 25:367–372. 2006.(In Chinese). PubMed/NCBI

19 

Goumenou AG, Matalliotakis IM, Tzardi M, Fragouli IG, Mahutte NG and Arici A: p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions. Fertil Steril 85 (Suppl 1). 1204–1207. 2006. View Article : Google Scholar

20 

Kovács KA, Oszter A, Göcze PM, Környei JL and Szabó I: Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium. Mol Hum Reprod. 7:1085–1091. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Velez AM Abreu and Howard MS: Tumor-suppressor Genes, Cell Cycle Regulatory Checkpoints, and the Skin. N Am J Med Sci. 7:176–188. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Dai X, Zhang X, Wang B, Wang C, Jiang J and Wu C: Association Between Polymorphism rs678653 in Human Cyclin D1 Gene (CCND1) and Susceptibility to Cancer: A Meta-Analysis. Med Sci Monit. 22:863–874. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Yang M, Zhu H, Hu T, Liu S and Wang H: Association of CCND1 gene polymorphism with cervical cancer susceptibility in Caucasian population: A meta-analysis. Int J Clin Exp Med. 8:12983–12988. 2015.PubMed/NCBI

24 

Shen LX, Basilion JP and Stanton VP Jr: Single-nucleotide polymorphisms can cause different structural folds of mRNA. Proc Natl Acad Sci USA. 96:7871–7876. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Salimi S, Shahrakipour M, Hajizadeh A, Mokhtari M, Mousavi M, Teimoori B and Yaghmaei M: Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis. Biomed Rep 6: 237-241, 2017.
APA
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., & Yaghmaei, M. (2017). Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis. Biomedical Reports, 6, 237-241. https://doi.org/10.3892/br.2016.830
MLA
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., Yaghmaei, M."Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis". Biomedical Reports 6.2 (2017): 237-241.
Chicago
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., Yaghmaei, M."Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis". Biomedical Reports 6, no. 2 (2017): 237-241. https://doi.org/10.3892/br.2016.830
Copy and paste a formatted citation
x
Spandidos Publications style
Salimi S, Shahrakipour M, Hajizadeh A, Mokhtari M, Mousavi M, Teimoori B and Yaghmaei M: Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis. Biomed Rep 6: 237-241, 2017.
APA
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., & Yaghmaei, M. (2017). Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis. Biomedical Reports, 6, 237-241. https://doi.org/10.3892/br.2016.830
MLA
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., Yaghmaei, M."Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis". Biomedical Reports 6.2 (2017): 237-241.
Chicago
Salimi, S., Shahrakipour, M., Hajizadeh, A., Mokhtari, M., Mousavi, M., Teimoori, B., Yaghmaei, M."Cyclin D1 G870A polymorphism: Association with uterine leiomyoma risk and in silico analysis". Biomedical Reports 6, no. 2 (2017): 237-241. https://doi.org/10.3892/br.2016.830
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team