Association of renal function with clinical parameters and conditions in a longitudinal population‑based epidemiological study

  • Authors:
    • Takuya Sumi
    • Mitsutoshi Oguri
    • Tetsuo Fujimaki
    • Hideki Horibe
    • Kimihiko Kato
    • Kota Matsui
    • Ichiro Takeuchi
    • Toyoaki Murohara
    • Yoshiji Yamada
  • View Affiliations

  • Published online on: December 23, 2016     https://doi.org/10.3892/br.2016.831
  • Pages: 242-250
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to examine the association of renal function with clinical parameters and conditions in the general population. Study subjects comprised 6,027 community‑dwelling individuals who were recruited to the Inabe Health and Longevity Study: A longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. The cutoff value, which was used to divide the subjects into those with normal and those with low estimated glomerular filtration rate (eGFR), was 60 ml/min/1.73 m2. Bonferroni's correction was applied to establish the statistical significance of the association. Longitudinal analysis using the generalized linear mixed‑effect model, following adjustments for age and gender, revealed that the eGFR was significantly associated (P<0.0017) with serum levels of triglycerides, low‑density lipoprotein cholesterol, uric acid, blood glycosylated hemoglobin content, fasting plasma glucose and body mass index. These parameters decreased curvilinearly with increases in eGFR. Furthermore, eGFR correlated positively with serum levels of high‑density lipoprotein (HDL) cholesterol. Longitudinal analysis using the generalized estimating equation following adjustment for age and gender indicated a significant association (P<0.0024) between eGFR and prevalence of hypertension, type 2 diabetes mellitus, hypo‑HDL cholesterolemia, hyperuricemia and obesity. Thus, low eGFR results in detrimental effects on various clinical parameters and conditions, resulting in increased risk of hypertension, dyslipidemia, type 2 diabetes mellitus, hyperuricemia and obesity.
View Figures
View References

Related Articles

Journal Cover

February-2017
Volume 6 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sumi T, Oguri M, Fujimaki T, Horibe H, Kato K, Matsui K, Takeuchi I, Murohara T and Yamada Y: Association of renal function with clinical parameters and conditions in a longitudinal population‑based epidemiological study. Biomed Rep 6: 242-250, 2017
APA
Sumi, T., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Matsui, K. ... Yamada, Y. (2017). Association of renal function with clinical parameters and conditions in a longitudinal population‑based epidemiological study. Biomedical Reports, 6, 242-250. https://doi.org/10.3892/br.2016.831
MLA
Sumi, T., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Matsui, K., Takeuchi, I., Murohara, T., Yamada, Y."Association of renal function with clinical parameters and conditions in a longitudinal population‑based epidemiological study". Biomedical Reports 6.2 (2017): 242-250.
Chicago
Sumi, T., Oguri, M., Fujimaki, T., Horibe, H., Kato, K., Matsui, K., Takeuchi, I., Murohara, T., Yamada, Y."Association of renal function with clinical parameters and conditions in a longitudinal population‑based epidemiological study". Biomedical Reports 6, no. 2 (2017): 242-250. https://doi.org/10.3892/br.2016.831