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Article

Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases

  • Authors:
    • Yan Jia
    • Yu Yue
    • Dan-Ning Hu
    • Ji-Li Chen
    • Ji-Bo Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, P.R. China, Departments of Ophthalmology and Pathology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA, Department of Ophthalmology, Shibei Hospital, Shanghai 200435, P.R. China
  • Pages: 573-578
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    Published online on: October 20, 2017
       https://doi.org/10.3892/br.2017.1004
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Abstract

The present study aims to investigate the association of transforming growth factor-β2 (TGF-β2) and matrix metalloproteinases (MMPs), MMP-2 and MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMPs), TIMP-1, TIMP-2 and TIMP-3 in the aqueous humor of patients with high myopia or cataracts. The levels of TGF-β2 and MMPs/TIMPs were measured with the Luminex xMAP Technology using commercially available Milliplex xMAP kits. The association between TGF-β2 and MMPs/TIMPs levels was analyzed using the Spearman's correlation test. The levels of TGF-β2 were identified to be positively correlated with the levels of TIMP-1 and TIMP-3 (TIMP-1: r=0.334; P=0.007; TIMP-3: r=0.309; P=0.012). The levels of MMP-2, MMP-3 and TIMP-2 did not significantly correlate with TGF-β2 levels (P>0.05). A positive correlation was identified between TGF-β2 and TIMPs in the aqueous humor of human eyes with elongated axial length. It appears that TGF-β2 stimulates the expression of TIMPs as a compensatory reaction to the development of high myopia.
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Copy and paste a formatted citation
Spandidos Publications style
Jia Y, Yue Y, Hu D, Chen J and Zhou J: Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases. Biomed Rep 7: 573-578, 2017.
APA
Jia, Y., Yue, Y., Hu, D., Chen, J., & Zhou, J. (2017). Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases. Biomedical Reports, 7, 573-578. https://doi.org/10.3892/br.2017.1004
MLA
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7.6 (2017): 573-578.
Chicago
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7, no. 6 (2017): 573-578. https://doi.org/10.3892/br.2017.1004
Copy and paste a formatted citation
x
Spandidos Publications style
Jia Y, Yue Y, Hu D, Chen J and Zhou J: Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases. Biomed Rep 7: 573-578, 2017.
APA
Jia, Y., Yue, Y., Hu, D., Chen, J., & Zhou, J. (2017). Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases. Biomedical Reports, 7, 573-578. https://doi.org/10.3892/br.2017.1004
MLA
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7.6 (2017): 573-578.
Chicago
Jia, Y., Yue, Y., Hu, D., Chen, J., Zhou, J."Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases". Biomedical Reports 7, no. 6 (2017): 573-578. https://doi.org/10.3892/br.2017.1004
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