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Article

Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population

  • Authors:
    • Sarahí Herrera‑González
    • Denisse Aideé Martínez‑Treviño
    • Marcelino Aguirre‑Garza
    • Magdalena Gómez‑Silva
    • Hugo Alberto Barrera‑Saldaña
    • Rafael Baltazar Reyes León‑Cachón
  • View Affiliations / Copyright

    Affiliations: Center of Molecular Diagnostics and Personalized Medicine, Department of Basic Sciences, Division of Health Sciences, University of Monterrey, San Pedro Garza Garcia, Nuevo León 66238, Mexico, Forensic Medicine Service, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, Mexico, Laboratory of Genomics and Bioinformatics, Department of Biochemistry and Molecular Medicine, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León 64460, Mexico
  • Pages: 579-584
    |
    Published online on: October 25, 2017
       https://doi.org/10.3892/br.2017.1009
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Abstract

Discrepancies in the response to drugs are partially due to polymorphisms in genes involved in drug metabolism and transport. The frequency, pattern and impact of these polymorphisms vary among populations. In the present study, the pharmacokinetics and pharmacogenetics of atorvastatin (ATV) in a Mexican population were investigated. The study cohort exhibited differing ATV metabolizing phenotypes, and in subsequent allelic discrimination assays, single nucleotide polymorphisms in the angiotensinogen, angiotensin II type 1 receptor (AGTR1) and bradykinin B2 receptor (BDKRB2) genes were genotyped and their effects on the pharmacokinetic parameters of ATV were assessed. Additionally, association studies were performed to test for a correlation between metabolizing phenotypes and genetic variants. It was observed that carriers of the genotypes A/C and C/T in AGTR1 and BDKRB2 had higher area under the plasma concentration‑time curve values from time 0 to the time of the last measurement and from time 0 extrapolated to infinity, and lower values of clearance of the fraction dose absorbed compared with homozygous carriers (P<0.05). Only the C/C genotype of BDKRB2 was associated with the fast metabolizer phenotype. These data suggest that AGTR1 and BDKRB2 are involved in ATV pharmacokinetics; a novel finding that requires confirmation in further studies.
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Copy and paste a formatted citation
Spandidos Publications style
Herrera‑González S, Martínez‑Treviño DA, Aguirre‑Garza M, Gómez‑Silva M, Barrera‑Saldaña HA and León‑Cachón RB: Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population. Biomed Rep 7: 579-584, 2017.
APA
Herrera‑González, S., Martínez‑Treviño, D.A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H.A., & León‑Cachón, R.B. (2017). Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population. Biomedical Reports, 7, 579-584. https://doi.org/10.3892/br.2017.1009
MLA
Herrera‑González, S., Martínez‑Treviño, D. A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H. A., León‑Cachón, R. B."Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population". Biomedical Reports 7.6 (2017): 579-584.
Chicago
Herrera‑González, S., Martínez‑Treviño, D. A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H. A., León‑Cachón, R. B."Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population". Biomedical Reports 7, no. 6 (2017): 579-584. https://doi.org/10.3892/br.2017.1009
Copy and paste a formatted citation
x
Spandidos Publications style
Herrera‑González S, Martínez‑Treviño DA, Aguirre‑Garza M, Gómez‑Silva M, Barrera‑Saldaña HA and León‑Cachón RB: Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population. Biomed Rep 7: 579-584, 2017.
APA
Herrera‑González, S., Martínez‑Treviño, D.A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H.A., & León‑Cachón, R.B. (2017). Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population. Biomedical Reports, 7, 579-584. https://doi.org/10.3892/br.2017.1009
MLA
Herrera‑González, S., Martínez‑Treviño, D. A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H. A., León‑Cachón, R. B."Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population". Biomedical Reports 7.6 (2017): 579-584.
Chicago
Herrera‑González, S., Martínez‑Treviño, D. A., Aguirre‑Garza, M., Gómez‑Silva, M., Barrera‑Saldaña, H. A., León‑Cachón, R. B."Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican population". Biomedical Reports 7, no. 6 (2017): 579-584. https://doi.org/10.3892/br.2017.1009
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