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Article Open Access

Increased serum chemerin level to predict early onset of aortic valve stenosis

  • Authors:
    • Juris Lurins
    • Dace Lurina
    • Peteris Tretjakovs
    • Vitolds Mackevics
    • Aivars Lejnieks
    • Venerando Rapisarda
    • Vincenzo Baylon
  • View Affiliations / Copyright

    Affiliations: Department of Doctoral Studies, Riga Stradins University, Riga, LV 1007, Latvia, Zemgale Health Centre, Jelgava, LV 3001, Latvia, Faculty of Medicine, Department of Human Physiology and Biochemistry, Riga Stradins University, Riga, LV 1007, Latvia, Faculty of Medicine, Department of Internal Diseases, Riga Stradins University, Riga, LV 1002, Latvia, Department of Clinical and Experimental Medicine, Occupational Medicine, University Hospital ‘Policlinico-Vittorio Emanuele’, University of Catania, I-95123 Catania, Italy, Newton Lewis Institute-ISR - Life Science Park, San Gwann 3000, Malta
    Copyright: © Lurins et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 31-36
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/br.2017.1010
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Abstract

Inflammation appears to be the cause of aortic valve (AoV) stenosis and identification of predictive biomarkers is therefore imperative. The aim of the current study was to evaluate the potential role of serum chemerin and fibroblast growth factor-21 (FGF-21) in the pathogenesis of the disease. A total of 102 patients were selected based on certain criteria and divided into an aortic stenosis group and a control group. Patients with AoV stenosis were subdivided into three groups depending on the severity according to the echocardiography criteria: Aortic jet velocity, Vmax (m/sec); mean pressure gradient, PG (mmHg); aortic valve area (AVA), cm2; and indexed AVA, cm2/m2. Patients were graded as: Severe: Vmax >4 m/sec, PG >40 mmHg, AVA <1.0 cm2, indexed AVA <0.6; moderate: Vmax 3.0-4.0 m/sec, PG 20-40 mmHg, AVA 1.0-1.5 cm2, indexed AVA 0.60-0.85; mild: Vmax 2.5-2.9 m/sec, PG <20 mmHg, AVA >1.5 cm2, indexed AVA >0.85. ELISA was used for the detection of chemerin and FGF-21. Post-hoc analysis with Tukey's correction was performed. The highest chemerin levels were found in mild and moderate AoV stenosis and decreased along with the grade of severity, compared with the control group. The FGF-21 level was increased in all the stenosis groups, reaching the highest level at severe stenosis. Receiver‑operating characteristic analysis of chemerin in all the AoV stenosis groups without grading the severity included, area under the curve (AUC)=0.76; 0.70-0.80= fair; P<0.001 and for mild AoV stenosis was AUC=0.82; 0.80-0.90= good; P<0.001. In conclusion, chemerin is a good diagnostic biomarker for mild AoV stenosis, while FGF-21 is a moderate diagnostic marker.
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Copy and paste a formatted citation
Spandidos Publications style
Lurins J, Lurina D, Tretjakovs P, Mackevics V, Lejnieks A, Rapisarda V and Baylon V: Increased serum chemerin level to predict early onset of aortic valve stenosis. Biomed Rep 8: 31-36, 2018.
APA
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., & Baylon, V. (2018). Increased serum chemerin level to predict early onset of aortic valve stenosis. Biomedical Reports, 8, 31-36. https://doi.org/10.3892/br.2017.1010
MLA
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., Baylon, V."Increased serum chemerin level to predict early onset of aortic valve stenosis". Biomedical Reports 8.1 (2018): 31-36.
Chicago
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., Baylon, V."Increased serum chemerin level to predict early onset of aortic valve stenosis". Biomedical Reports 8, no. 1 (2018): 31-36. https://doi.org/10.3892/br.2017.1010
Copy and paste a formatted citation
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Spandidos Publications style
Lurins J, Lurina D, Tretjakovs P, Mackevics V, Lejnieks A, Rapisarda V and Baylon V: Increased serum chemerin level to predict early onset of aortic valve stenosis. Biomed Rep 8: 31-36, 2018.
APA
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., & Baylon, V. (2018). Increased serum chemerin level to predict early onset of aortic valve stenosis. Biomedical Reports, 8, 31-36. https://doi.org/10.3892/br.2017.1010
MLA
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., Baylon, V."Increased serum chemerin level to predict early onset of aortic valve stenosis". Biomedical Reports 8.1 (2018): 31-36.
Chicago
Lurins, J., Lurina, D., Tretjakovs, P., Mackevics, V., Lejnieks, A., Rapisarda, V., Baylon, V."Increased serum chemerin level to predict early onset of aortic valve stenosis". Biomedical Reports 8, no. 1 (2018): 31-36. https://doi.org/10.3892/br.2017.1010
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