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Article

Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

  • Authors:
    • Krisana Asano
    • Emiko Takahashi
    • Sayuri Yoshimura
    • Akio Nakane
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan, Biopolymer and Health Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan
  • Pages: 37-40
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/br.2017.1011
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Abstract

Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site.
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Copy and paste a formatted citation
Spandidos Publications style
Asano K, Takahashi E, Yoshimura S and Nakane A: Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomed Rep 8: 37-40, 2018.
APA
Asano, K., Takahashi, E., Yoshimura, S., & Nakane, A. (2018). Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomedical Reports, 8, 37-40. https://doi.org/10.3892/br.2017.1011
MLA
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8.1 (2018): 37-40.
Chicago
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8, no. 1 (2018): 37-40. https://doi.org/10.3892/br.2017.1011
Copy and paste a formatted citation
x
Spandidos Publications style
Asano K, Takahashi E, Yoshimura S and Nakane A: Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomed Rep 8: 37-40, 2018.
APA
Asano, K., Takahashi, E., Yoshimura, S., & Nakane, A. (2018). Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomedical Reports, 8, 37-40. https://doi.org/10.3892/br.2017.1011
MLA
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8.1 (2018): 37-40.
Chicago
Asano, K., Takahashi, E., Yoshimura, S., Nakane, A."Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice". Biomedical Reports 8, no. 1 (2018): 37-40. https://doi.org/10.3892/br.2017.1011
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