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Article

Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients

  • Authors:
    • Alicia Ocaña‑Mondragón
    • José Antonio Mata‑Marín
    • Mario Uriarte‑López
    • Carolina Bekker‑Méndez
    • Enrique Alcalá‑Martínez
    • Rosa María Ribas‑Aparicio
    • Luis Antonio Uribe‑Noguéz
    • Dulce María Rodríguez‑Galindo
    • María de La Luz Martínez‑Rodríguez
  • View Affiliations / Copyright

    Affiliations: Unidad de Investigación Biomédica en Infectología e Inmunología, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico, Unidad Médica de Alta Especialidad, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico, Departamento de Investigación y Desarrollo, AYDSA Aminas y Derivados S.A. de C.V., Mexico City 06400, Mexico, Departamento de Microbiología, Programa en Biomedicina y Biotecnología Molecular, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City 11340, Mexico, Departamento de Psicología Clínica, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico
  • Pages: 85-90
    |
    Published online on: November 3, 2017
       https://doi.org/10.3892/br.2017.1012
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Abstract

The incidence rate of insulin resistance (IR) in patients with chronic hepatitis C (CHC) is high. Recently, branched‑chain amino acids (BCAA) have been shown to attenuate IR in CHC patients; however, their effect on patient quality of life remains unclear. Therefore, the aim of the current prospective study was to determine the effects of BCAA supplement on IR and health‑related quality of life (HR‑QoL) in patients with CHC. In the study, 20 non‑diabetic patients with CHC, who were non‑responders to peginterferon‑α and ribavirin, were recruited. Patients took a BCAA supplement once a day (30 g, after a minimum 10‑h overnight fast) for 3 months. Serum levels of glucose, insulin, albumin, triglycerides and cholesterol were measured at 0 and 3 months. Additionally, IR was measured using the Homeostasis Model Assessment‑IR, HR‑QoL was assessed using the 36‑item Short Form Health Survey and viral load was measured by reverse transcription polymerase chain reaction using Taqman probes. The Wilcoxon signed‑rank test was used to determine statistical significance. The results indicated that 70% of the subjects were positive for IR, which decreased to 50% by the end of the study; furthermore, 85% of the subjects demonstrated some level of improvement. Overall, the BCAA treatment significantly decreased IR (P=0.006) and augmented serum albumin concentration (P=0.008) compared with basal values. Additionally, by the end of the treatment, viral load and triglycerides levels had decreased, though these results were not significant (P=0.084 and P=0.080, respectively). BCAA treatment also improved HR‑QoL regarding role limitations due to physical health problems (P=0.017), role limitations due to emotional problems (P=0.026) and social function (P=0.008). In conclusion, BCAA supplementation reduced IR and improved HR‑QoL in patients with CHC. These findings support the application of IR therapy as a possible therapeutic strategy for hepatitis C infection.
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1 

El Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 142:1264–1273. e12612012.https://doi.org/10.1053/j.gastro.2011.12.061 View Article : Google Scholar : PubMed/NCBI

2 

Lozano-Sepulveda SA, Bryan-Marrugo OL, Cordova-Fletes C, Gutierrez-Ruiz MC and Rivas-Estilla AM: Oxidative stress modulation in hepatitis C virus infected cells. World J Hepatol. 7:2880–2889. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Romero-Gómez M: Insulin resistance and hepatitis C. World J Gastroenterol. 12:7075–7080. 2006. View Article : Google Scholar : PubMed/NCBI

4 

García-Montalvo BM and Macossay-Castillo M: Preliminary data for genotype distribution and epidemiological aspects of hepatitis C virus infection in blood donors from Yucatan, Mexico. Transfus Med. 17:488–490. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Koike K, Tsutsumi T, Yotsuyanagi H and Moriya K: Lipid metabolism and liver disease in hepatitis C viral infection. Oncology. 78 Suppl 1:24–30. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Chang ML: Metabolic alterations and hepatitis C From bench to bedside. World J Gastroenterol. 22:1461–1476. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Sheikh MY, Choi J, Qadri I, Friedman JE and Sanyal AJ: Hepatitis C virus infection: Molecular pathways to metabolic syndrome. Hepatology. 47:2127–2133. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Milner KL, Jenkins AB, Trenell M, Tid-Ang J, Samocha-Bonet D, Weltman M, Xu A, George J and Chisholm DJ: Eradicating hepatitis C virus ameliorates insulin resistance without change in adipose depots. J Viral Hepat. 21:325–332. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Bose SK and Ray R: Hepatitis C virus infection and insulin resistance. World J Diabetes. 5:52–58. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Parvaiz F, Manzoor S, Tariq H, Javed F, Fatima K and Qadri I: Hepatitis C virus infection: Molecular pathways to insulin resistance. Virol J. 8:4742011. View Article : Google Scholar : PubMed/NCBI

11 

Kim KA, Lin W, Tai AW, Shao RX, Weinberg E, De Sa Borges CB, Bhan AK, Zheng H, Kamegaya Y and Chung RT: Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection. J Hepatol. 50:705–711. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Banerjee A, Meyer K, Mazumdar B, Ray RB and Ray R: Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression. J Virol. 84:5936–5946. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Deltenre P, Louvet A, Lemoine M, Mourad A, Fartoux L, Moreno C, Henrion J, Mathurin P and Serfaty L: Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: A meta-analysis. J Hepatol. 55:1187–1194. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Mason AL, Lau JY, Hoang N, Qian K, Alexander GJ, Xu L, Guo L, Jacob S, Regenstein FG, Zimmerman R, et al: Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology. 29:328–333. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Bose SK, Shrivastava S, Meyer K, Ray RB and Ray R: Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. J Virol. 86:6315–6322. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, Ide YH and Hotta H: Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol. 85:8556–8568. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Knobler H and Malnick S: Hepatitis C and insulin action: An intimate relationship. World J Hepatol. 8:131–138. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Romero-Gómez M, Del Mar Viloria M, Andrade RJ, Salmerón J, Diago M, Fernández-Rodríguez CM, Corpas R, Cruz M, Grande L, Vázquez L, et al: Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology. 128:636–641. 2005. View Article : Google Scholar : PubMed/NCBI

19 

De Bandt JP and Cynober L: Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr. 136:308S–313S. 2006.PubMed/NCBI

20 

Wullschleger S, Loewith R and Hall MN: TOR signaling in growth and metabolism. Cell. 124:471–484. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Averous J and Proud CG: When translation meets transformation: The mTOR story. Oncogene. 25:6423–6435. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Nobukuni T, Kozma SC and Thomas G: hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol. 19:135–141. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Abad-Lacruz A, Cabré E, González-Huix F, Fernández-Bañares F, Esteve M, Planas R, Llovet JM, Quer JC and Gassull MA: Routine tests of renal function, alcoholism, and nutrition improve the prognostic accuracy of Child-Pugh score in nonbleeding advanced cirrhotics. Am J Gastroenterol. 88:382–387. 1993.PubMed/NCBI

24 

Blonde-Cynober F, Aussel C and Cynober L: Abnormalities in branched-chain amino acid metabolism in cirrhosis: Influence of hormonal and nutritional factors and directions for future research. Clin Nutr. 18:5–13. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Okuno M, Moriwaki H, Kato M, Muto Y and Kojima S: Changes in the ratio of branched-chain to aromatic amino acids affect the secretion of albumin in cultured rat hepatocytes. Biochem Biophys Res Commun. 214:1045–1050. 1995. View Article : Google Scholar : PubMed/NCBI

26 

She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ and Hutson SM: Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 6:181–194. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Korenaga K, Korenaga M, Uchida K, Yamasaki T and Sakaida I: Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis. Hepatol Res. 38:1087–1097. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Sakaida I, Tsuchiya M, Okamoto M and Okita K: Late evening snack and the change of blood glucose level in patients with liver cirrhosis. Hepatol Res. 30S:1–72. 2004.PubMed/NCBI

29 

Kawaguchi T, Nagao Y, Matsuoka H, Ide T and Sata M: Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease. Int J Mol Med. 22:105–112. 2008.PubMed/NCBI

30 

Kawaguchi T, Taniguchi E, Itou M, Sumie S, Oriishi T, Matsuoka H, Nagao Y and Sata M: Branched-chain amino acids improve insulin resistance in patients with hepatitis C virus-related liver disease: Report of two cases. Liver Int. 27:1287–1292. 2007.PubMed/NCBI

31 

Syed GH, Amako Y and Siddiqui A: Hepatitis C virus hijacks host lipid metabolism. Trends Endocrinol Metab. 21:33–40. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Amako Y, Munakata T, Kohara M, Siddiqui A, Peers C and Harris M: Hepatitis C virus attenuates mitochondrial lipid β-oxidation by downregulating mitochondrial trifunctional-protein expression. J Virol. 89:4092–4101. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Ramcharran D, Wahed AS, Conjeevaram HS, Evans RW, Wang T, Belle SH and Yee LJ: Serum lipids and their associations with viral levels and liver disease severity in a treatment-naïve chronic hepatitis C type 1-infected cohort. J Viral Hepat. 18:e144–e152. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Gross CR, Malinchoc M, Kim WR, Evans RW, Wiesner RH, Petz JL, Crippin JS, Klintmalm GB, Levy MF, Ricci P, et al: Quality of life before and after liver transplantation for cholestatic liver disease. Hepatology. 29:356–364. 1999. View Article : Google Scholar : PubMed/NCBI

35 

Kawamura N, Nakajima H and Takashi SI: Administration of granulated BCAA and quality of life. Hepatol Res. 30S:1–45. 2004.PubMed/NCBI

36 

Kawaguchi T, Taniguchi E and Sata M: Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis. Nutr Clin Pract. 28:580–588. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Levy JC, Matthews DR and Hermans MP: Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 21:2191–2192. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Hernández Yero JA, Tuero Iglesias Á and Vargas González D: Utilidad del índice HOMA IR con una sola determinación de insulinemia para diagnosticar resistencia insulínica. Rev Cuba Endocrinol. 22:69–77. 2011.

39 

Buccini GS and Wolfthal DL: Valores de corte para índices de insulinorresistencia, insulinosensibilidad e insulinosecreción derivados de la fórmula HOMA y del programa HOMA2: Interpretación de los datos. Revista argentina de endocrinología y metabolismo. 45:03 212008.

40 

Vilagut G, Ferrer M, Rajmil L, Rebollo P, Permanyer-Miralda G, Quintana JM, Santed R, Valderas JM, Ribera A, Domingo-Salvany A, et al: El Cuestionario de Salud SF-36 español: Una década de experiencia y nuevos desarrollos. Gac Sanit. 19:135–150. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Garrouste-Orgeas M, Troché G, Azoulay E, Caubel A, de Lassence A, Cheval C, Montesino L, Thuong M, Vincent F, Cohen Y, et al: Body mass index. An additional prognostic factor in ICU patients. Intensive Care Med. 30:437–443. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Rouvière O, Yin M, Dresner MA, Rossman PJ, Burgart LJ, Fidler JL and Ehman RL: MR elastography of the liver: Preliminary results. Radiology. 240:440–448. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Bota S, Sirli R, Sporea I, Focsa M, Popescu A, Danila M, Strain M, Sendroiu M, Deleanu A and Dan I: A new scoring system for prediction of fibrosis in chronic hepatitis C. Hepat Mon. 11:548–555. 2011.PubMed/NCBI

44 

Gluud C, Conn HO and Eriksson LS: Branched-chain amino acids for hepatic encephalopathy? Hepatology. 13:812–813. 1991. View Article : Google Scholar : PubMed/NCBI

45 

Charlton M: Branched-chain amino acid enriched supplements as therapy for liver disease. J Nutr. 136:295S–298S. 2006.PubMed/NCBI

46 

Chen L, Chen Y, Wang X, Li H, Zhang H, Gong J, Shen S, Yin W and Hu H: Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: A meta-analysis. Nutr J. 14:672015. View Article : Google Scholar : PubMed/NCBI

47 

Muto Y, Sato S, Watanabe A, Moriwaki H, Suzuki K, Kato A, Kato M, Nakamura T, Higuchi K, Nishiguchi S, et al Long-Term Survival Study Group, : Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol. 3:705–713. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Higuchi N, Kato M, Miyazaki M, Tanaka M, Kohjima M, Ito T, Nakamuta M, Enjoji M, Kotoh K and Takayanagi R: Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver. J Cell Biochem. 112:30–38. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Adeva MM, Calviño J, Souto G and Donapetry C: Insulin resistance and the metabolism of branched-chain amino acids in humans. Amino Acids. 43:171–181. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Knowler WC, Narayan KM, Hanson RL, Nelson RG, Bennett PH, Tuomilehto J, Scherstén B and Pettitt DJ: Preventing non-insulin-dependent diabetes. Diabetes. 44:483–488. 1995. View Article : Google Scholar : PubMed/NCBI

51 

Takeshita Y, Takamura T, Kita Y, Ando H, Ueda T, Kato K, Misu H, Sunagozaka H, Sakai Y, Yamashita T, et al: Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes. Metabolism. 61:1388–1394. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ocaña‑Mondragón A, Mata‑Marín JA, Uriarte‑López M, Bekker‑Méndez C, Alcalá‑Martínez E, Ribas‑Aparicio RM, Uribe‑Noguéz LA, Rodríguez‑Galindo DM and Martínez‑Rodríguez Md: Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients. Biomed Rep 8: 85-90, 2018.
APA
Ocaña‑Mondragón, A., Mata‑Marín, J.A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R.M. ... Martínez‑Rodríguez, M.d. (2018). Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients. Biomedical Reports, 8, 85-90. https://doi.org/10.3892/br.2017.1012
MLA
Ocaña‑Mondragón, A., Mata‑Marín, J. A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R. M., Uribe‑Noguéz, L. A., Rodríguez‑Galindo, D. M., Martínez‑Rodríguez, M. d."Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients". Biomedical Reports 8.1 (2018): 85-90.
Chicago
Ocaña‑Mondragón, A., Mata‑Marín, J. A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R. M., Uribe‑Noguéz, L. A., Rodríguez‑Galindo, D. M., Martínez‑Rodríguez, M. d."Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients". Biomedical Reports 8, no. 1 (2018): 85-90. https://doi.org/10.3892/br.2017.1012
Copy and paste a formatted citation
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Spandidos Publications style
Ocaña‑Mondragón A, Mata‑Marín JA, Uriarte‑López M, Bekker‑Méndez C, Alcalá‑Martínez E, Ribas‑Aparicio RM, Uribe‑Noguéz LA, Rodríguez‑Galindo DM and Martínez‑Rodríguez Md: Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients. Biomed Rep 8: 85-90, 2018.
APA
Ocaña‑Mondragón, A., Mata‑Marín, J.A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R.M. ... Martínez‑Rodríguez, M.d. (2018). Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients. Biomedical Reports, 8, 85-90. https://doi.org/10.3892/br.2017.1012
MLA
Ocaña‑Mondragón, A., Mata‑Marín, J. A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R. M., Uribe‑Noguéz, L. A., Rodríguez‑Galindo, D. M., Martínez‑Rodríguez, M. d."Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients". Biomedical Reports 8.1 (2018): 85-90.
Chicago
Ocaña‑Mondragón, A., Mata‑Marín, J. A., Uriarte‑López, M., Bekker‑Méndez, C., Alcalá‑Martínez, E., Ribas‑Aparicio, R. M., Uribe‑Noguéz, L. A., Rodríguez‑Galindo, D. M., Martínez‑Rodríguez, M. d."Effect of branched‑chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients". Biomedical Reports 8, no. 1 (2018): 85-90. https://doi.org/10.3892/br.2017.1012
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