Gene polymorphisms of fibronectin rs2289202 and fibrillin 2 rs331069 associate with vascular disease, the TAMRISK study

Kunnas,Tarja; Solakivi,Tiina; Nikkari,Seppo  T.

doi:10.3892/br.2017.1020

January-2018 Volume 8 Issue 1

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January-2018 Volume 8 Issue 1

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Article

Gene polymorphisms of fibronectin rs2289202 and fibrillin 2 rs331069 associate with vascular disease, the TAMRISK study

Authors:
- Tarja Kunnas
- Tiina Solakivi
- Seppo T. Nikkari
View Affiliations / Copyright

Affiliations: Department of Medical Biochemistry, Faculty of Medicine and Life Sciences, University of Tampere Medical School, 33014 Tampere, Finland
Pages: 65-68
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Published online on: November 17, 2017

https://doi.org/10.3892/br.2017.1020
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Abstract

Cell surface heparan sulfate (HS) proteoglycans interact with other extracellular matrix (ECM) components, and HS‑binding regions are present in ECM proteins such as fibronectin and fibrillin. Because of their previously established role in susceptibility to intracranial aneurysms, the authors sought to determine whether polymorphisms of fibronectin (FN1, rs2289202) and fibrillin 2 (FBN2, rs331069) associate with selected cardiovascular risk factors and events in the TAMRISK study. A 50‑year‑old Finnish cohort of 810 subjects of whom 340 had diagnosed hypertension was analyzed. Samples were genotyped for FN1 rs2289202 and FBN2 rs331069 polymorphisms. Incidence of myocardial infarction (I21‑I22), transient cerebral ischemic attacks (TIA, G45) and cerebrovascular diseases (I60‑I69) were followed up until the subjects were on the average 60 years old. Subjects with FN1 rs2289202 (G>A) minor genotype AA had significantly more cerebrovascular disease than those with the G allele [P<0.001, odds ratio (OR), 8.73; confidence index (CI), 2.79‑27.31], although those with the A allele had lower body mass index (P=0.008). Subjects with fibrillin rs331069 (T>C) minor genotype CC had more atherothrombotic disease (P=0.012, OR, 3.16; CI, 1.29‑7.71), as measured by combined myocardial infarction and TIA, than those with the T allele. The gene polymorphisms for fibronectin and fibrillin 2 appear to associate with vascular disease.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gene polymorphisms of fibronectin rs2289202 and fibrillin 2 rs331069 associate with vascular disease, the TAMRISK study

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