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Article

Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents

  • Authors:
    • Qian Li
    • Quankun Zhuang
    • Yaru Gu
    • Cailing Dai
    • Xiaoxiao Gao
    • Xiaomin Wang
    • Huimin Wen
    • Xin Li
    • Yuyang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China
  • Pages: 176-183
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/br.2017.1032
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Abstract

Nefopam, an analgesic drug, effectively elicits antinociception in the majority of noxious and thermal models in rodents. Acetaminophen is among the most commonly used analgesic and antipyretic drugs worldwide, either on prescription or over the counter. The present study aimed to investigate the analgesic activity of nefopam combined with acetaminophen, which was expected to maximize the potency of analgesia and decrease the dose of nefopam required. Three series of experiments, namely acetic acid‑induced writhing tests in mice, hot plate tests in mice and tail flick tests in rats, were used to evaluate the analgesic effect. Initially, an optimum proportion of the two drugs, 3.5 mg/kg nefopam (N) + 60 mg/kg acetaminophen (A), was determined by orthogonal array design based on writhing response number. Subsequently, combinations of N and A (1.75 N + 30 A, 3.5 N + 60 A and 7.0 N + 120 A mg/kg) were determined to elicit antinociception in the writhing test (P<0.01 vs. normal saline control) in a dose-dependent manner. In the hot plate test, hot plate latencies up to 60 min after drug treatment were observed. The combination of 7.0 N + 120 A mg/kg exerted a greater cumulative antinociceptive effect throughout the observation period, with an area under the curve value of 1,156.95±199.30 area units (AU), compared with that achieved by 7.0 N mg/kg alone (632.12±62.38 AU). Furthermore, both monotherapy and compound therapy exhibited antinociception dose‑dependently in the tail-flick test. However, a combination of 5.0 N + 84 A mg/kg exerted greater analgesic effect compared with 5.0 N mg/kg alone. The data obtained demonstrate that acetaminophen may enhance the antinociceptive activity of nefopam. Thus, coadministration of nefopam with acetaminophen warrants clinical evaluation.
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1 

Aveline C, Gautier JF, Vautier P, Cognet F, Hetet HL, Attali JY, Leconte V, Leborgne P and Bonnet F: Postoperative analgesia and early rehabilitation after total knee replacement: A comparison of continuous low-dose intravenous ketamine versus nefopam. Eur J Pain. 13:613–619. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Evans MS, Lysakowski C and Tramèr MR: Nefopam for the prevention of postoperative pain: Quantitative systematic review. Br J Anaesth. 101:610–617. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Girard P, Verniers D, Coppé MC, Pansart Y and Gillardin JM: Nefopam and ketoprofen synergy in rodent models of antinociception. Eur J Pharmacol. 584:263–271. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Laboureyras E, Chateauraynaud J, Richebé P and Simonnet G: Long-term pain vulnerability after surgery in rats: Prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg. 109:623–631. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Cho SY, Park AR, Yoon MH, Lee HG, Kim WM and Choi JI: Antinociceptive effect of intrathecal nefopam and interaction with morphine in formalin-induced pain of rats. Korean J Pain. 26:14–20. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kim KH and Abdi S: Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 27:103–111. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Durrieu G, Olivier P, Bagheri H and Montastruc JL: French network of pharmacovigilance centers: Overview of adverse reactions to nefopam: An analysis of the French pharmacovigilance database. Fundam Clin Pharmacol. 21:555–558. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Majchrzycki M, Kocur P and Kotwicki T: Deep tissue massage and nonsteroidal anti-inflammatory drugs for low back pain: A prospective randomized trial. Sci World J. 2014:2875972014. View Article : Google Scholar

9 

Pongparadee C, Penserga E, Lee DJ, Chen SL, Gill RS, Hamid A, Kumthornthip W, Liu Y, Meliala L, Misbach HJ, et al: Current considerations for the management of musculoskeletal pain in Asian countries: A special focus on cyclooxygenase-2 inhibitors and non-steroid anti-inflammation drugs. Int J Rheum Dis. 15:341–347. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Nikoda VV, Maiachkin RB and Bondarenko AV: Clinical aspects of using patient-controlled analgesia with nonsteroidal anti-inflammatory agents in postoperative period. Anesteziol Reanimatol. 56–59. 2003.(In Russian). PubMed/NCBI

11 

Vanegas H and Schaible HG: Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord. Prog Neurobiol. 64:327–363. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Isuru A, Rodrigo A, Wijesinghe C, Ediriweera D, Premadasa S, Wijesekara C and Kuruppuarachchi L: A randomized, double-blind, placebo-controlled trial on the role of preemptive analgesia with acetaminophen [paracetamol] in reducing headache following electroconvulsive therapy [ECT]. BMC Psychiatry. 17:2752017. View Article : Google Scholar : PubMed/NCBI

13 

Di Girolamo G, Sánchez AJ, De Los Santos AR and González CD: Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? Expert Opin Pharmacother. 5:561–570. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Botting RM: Inhibitors of cyclooxygenases: Mechanisms, selectivity and uses. J Physiol Pharmacol. 57 Suppl 5:113–124. 2006.PubMed/NCBI

15 

Ruggieri V, Vitale G, Pini LA and Sandrini M: Differential involvement of opioidergic and serotonergic systems in the antinociceptive activity of N-arachidonoyl-phenolamine (AM404) in the rat: Comparison with paracetamol. Naunyn Schmiedebergs Arch Pharmacol. 377:219–229. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Sandrini M, Vitale G, Ruggieri V and Pini LA: Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats. Inflamm Res. 56:139–142. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Roshi D, Toçi E, Burazeri G, Schröder-Bäck P, Malaj L and Brand H: Users' knowledge about adverse effects of non-steroidal anti-inflammatory drugs in Tirana, Albania. Mater Sociomed. 29:138–142. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Zhou C, Hu J, Ma H, Yagoub AE, Yu X, Owusu J, Ma H and Qin X: Antioxidant peptides from corn gluten meal: Orthogonal design evaluation. Food Chem. 187:270–278. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhao J, Yuan Q, Cai W, Sun P, Ding L and Jin F: Formulation, optimization, characterization, and pharmacokinetics of progesterone intravenous lipid emulsion for traumatic brain injury therapy. AAPS PharmSciTech. 18:1475–1487. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Yang YU, Bai W, Chen Y, Lin Y and Hu B: Optimization of low-frequency low-intensity ultrasound-mediated microvessel disruption on prostate cancer xenografts in nude mice using an orthogonal experimental design. Oncol Lett. 10:2999–3007. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Du L, Pan H, Li L and Su X: Enhanced analgesic effects of propacetamol and tramadol combination in rats and mice. Biol Pharm Bull. 34:349–353. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Cheng J, Ma T, Liu W, Wang H, Jiang J, Wei Y, Tian H, Zou N, Zhu Y, Shi H, et al: In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models. BMC Complement Altern Med. 16:202016. View Article : Google Scholar : PubMed/NCBI

23 

Delage N, Maaliki H, Beloeil H, Benhamou D and Mazoit JX: Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: A study of interaction using sequential analysis and isobolographic analysis. Anesthesiology. 102:1211–1216. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Van Elstraete AC and Sitbon P: Median effective dose (ED50) of paracetamol and nefopam for postoperative pain: Isobolographic analysis of their antinociceptive interaction. Minerva Anestesiol. 79:232–239. 2013.PubMed/NCBI

25 

Girard P, Niedergang B, Pansart Y, Coppé MC and Verleye M: Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. Clin Exp Pharmacol Physiol. 38:170–178. 2011. View Article : Google Scholar : PubMed/NCBI

26 

de la Puente B, Zamanillo D, Romero L, Vela JM, Merlos M and Portillo-Salido E: Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice. Sci Rep. 7:134282017. View Article : Google Scholar : PubMed/NCBI

27 

Gu WW, Ao GZ, Zhu YM, Sun SC, Zhou Q, Fan JH, Nobuhiko K, Ishidoh K, Zhang HL and Gao XM: Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model. Acta Pharmacol Sin. 34:1007–1012. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Vliegenthart AD, Shaffer JM, Clarke JI, Peeters LE, Caporali A, Bateman DN, Wood DM, Dargan PI, Craig DG, Moore JK, et al: Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Sci Rep. 5:155012015. View Article : Google Scholar : PubMed/NCBI

29 

Vellani V and Giacomoni C: Gabapentin inhibits protein kinase C epsilon translocation in cultured sensory neurons with additive effects when coapplied with paracetamol (Acetaminophen). Sci World J. 2017:35959032017. View Article : Google Scholar

30 

Lancaster EM, Hiatt JR and Zarrinpar A: Acetaminophen hepatotoxicity: An updated review. Arch Toxicol. 89:193–199. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato AB, Poole S, Ferreira SH and Cunha FQ: Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol. 387:111–118. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Chan SL and Yeung JH: Polysaccharide peptides from COV-1 strain of Coriolus versicolor induce hyperalgesia via inflammatory mediator release in the mouse. Life Sci. 78:2463–2470. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Maleki-Dizaji N, Fathiazad F and Garjani A: Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa. Arch Pharm Res. 30:1536–1542. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Jokinen V, Lilius T, Laitila J, Niemi M, Kambur O, Kalso E and Rauhala P: Do diuretics have antinociceptive actions: Studies of spironolactone, eplerenone, furosemide and chlorothiazide, individually and with oxycodone and morphine. Basic Clin Pharmacol Toxicol. 120:38–45. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Gong YH, Yu XR, Liu HL, Yang N, Zuo PP and Huang YG: Antinociceptive effects of combination of tramadol and acetaminophen on painful diabetic neuropathy in streptozotocin-induced diabetic rats. Acta Anaesthesiol Taiwan. 49:16–20. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Miranda HF, Noriega V and Prieto JC: Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice. Pharmacol Biochem Behav. 102:72–76. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Nagai J, Uesawa Y, Shimamura R and Kagaya H: Characterization of the adverse effects induced by acetaminophen and nonsteroidal anti-inflammatory drugs based on the analysis of the Japanese adverse drug event report database. Clin J Pain. 33:667–675. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Kim YJ, Lim KH, Kim MY, Jo EJ, Lee SY, Lee SE, Yang MS, Song WJ, Kang HR, Park HW, et al: Cross-reactivity to acetaminophen and celecoxib according to the type of nonsteroidal anti-inflammatory drug hypersensitivity. Allergy Asthma Immunol Res. 6:156–162. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Hinz B, Cheremina O and Brune K: Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J. 22:383–390. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS and Simmons DL: COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci USA. 99:13926–13931. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Snipes JA, Kis B, Shelness GS, Hewett JA and Busija DW: Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat. J Pharmacol Exp Ther. 313:668–676. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Bonnefont J, Daulhac L, Etienne M, Chapuy E, Mallet C, Ouchchane L, Deval C, Courade JP, Ferrara M, Eschalier A, et al: Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system. Mol Pharmacol. 71:407–415. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Courade JP, Chassaing C, Bardin L, Alloui A and Eschalier A: 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. Eur J Pharmacol. 432:1–7. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Mallet C, Daulhac L, Bonnefont J, Ledent C, Etienne M, Chapuy E, Libert F and Eschalier A: Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain. 139:190–200. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R and Leone S: Paracetamol: New vistas of an old drug. CNS Drug Rev. 12:250–275. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI and Zygmunt PM: Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 280:31405–31412. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Jeong SH, Heo BH, Park SH, Kim WM, Lee HG, Yoon MH and Choi JI: Spinal noradrenergic modulation and the role of the alpha-2 receptor in the antinociceptive effect of intrathecal nefopam in the formalin test. Korean J Pain. 27:23–29. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Girard P, Pansart Y, Coppé MC, Verniers D and Gillardin JM: Role of the histamine system in nefopam-induced antinociception in mice. Eur J Pharmacol. 503:63–69. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Girard P, Coppé MC, Verniers D, Pansart Y and Gillardin JM: Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacol Res. 54:195–202. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Tiippana E, Hamunen K, Kontinen V and Kalso E: The effect of paracetamol and tropisetron on pain: Experimental studies and a review of published data. Basic Clin Pharmacol Toxicol. 112:124–131. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Dogrul A, Seyrek M, Akgul EO, Cayci T, Kahraman S and Bolay H: Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT7 receptors. Eur J Pharmacol. 677:93–101. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Dam LJ, Hai L and Ha YM: Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neurosci Lett. 566:50–54. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Lee HG, Kim WM, Kim JM, Bae HB and Choi JI: Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors. Neurosci Lett. 587:120–125. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Zhuang Q, Gu Y, Dai C, Gao X, Wang X, Wen H, Li X and Zhang Y: Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents. Biomed Rep 8: 176-183, 2018.
APA
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X. ... Zhang, Y. (2018). Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents. Biomedical Reports, 8, 176-183. https://doi.org/10.3892/br.2017.1032
MLA
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X., Wen, H., Li, X., Zhang, Y."Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents". Biomedical Reports 8.2 (2018): 176-183.
Chicago
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X., Wen, H., Li, X., Zhang, Y."Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents". Biomedical Reports 8, no. 2 (2018): 176-183. https://doi.org/10.3892/br.2017.1032
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Zhuang Q, Gu Y, Dai C, Gao X, Wang X, Wen H, Li X and Zhang Y: Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents. Biomed Rep 8: 176-183, 2018.
APA
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X. ... Zhang, Y. (2018). Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents. Biomedical Reports, 8, 176-183. https://doi.org/10.3892/br.2017.1032
MLA
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X., Wen, H., Li, X., Zhang, Y."Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents". Biomedical Reports 8.2 (2018): 176-183.
Chicago
Li, Q., Zhuang, Q., Gu, Y., Dai, C., Gao, X., Wang, X., Wen, H., Li, X., Zhang, Y."Enhanced analgesic effects of nefopam in combination with acetaminophen in rodents". Biomedical Reports 8, no. 2 (2018): 176-183. https://doi.org/10.3892/br.2017.1032
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